EU Universe Awareness (EU-UNAWE), een educatief sterrenkundeproject van de Leidse Sterrewacht, heeft gloednieuw lesmateriaal ontwikkeld: Universe in a Box. Het toegankelijke lespakket is ontworpen om de moeilijke en soms abstracte concepten van sterrenkunde uit te leggen aan jonge kinderen van 4 tot…

Het project Universe Awareness (UNAWE) van de Universiteit Leiden organiseert een Kickstarter crowdfunding campagne om de lespakketten van 'Universe in a Box', een lespakket voor sterrenkunde, zoveel mogelijk te kunnen verspreiden onder kansarme gemeenschappen over de hele wereld. De campagne werd gelanceerd…

De moslimwereld kent door haar vroege beschaving en voortdurende vermenging van invloeden een rijke en gevarieerde cultuur. Het bestuderen van materiële cultuur, boeken, verhalen, films en, steeds vaker, televisieseries leert ons meer over hoe hedendaagse moslimsamenlevingen in elkaar zitten.

In de recent verschenen bundel Wat een vondst! Verhalen uit de geschiedenispraktijk vertellen vijftien militair- en koloniale historici over een belangrijke vondst in hun wetenschappelijke loopbaan.

Lorenza Colzato wil onderzoeken of het gebruik van probiotica en tryptofaan de sociaal-cognitieve achteruitgang die optreedt bij het ouder worden, kan vertragen. Daarvoor ontvangt Colzato samen met haar collega's in Duitsland en Spanje een JPI 'A Healthy Diet for A Healthy Life' Joint Transnational…

Alumni-activiteit

Wiskunde en Natuurwetenschappen

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

Heart failure is a major health care problem with high mortality.

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Gibbs measures, as used in Statistical Mechanics, have a definition that is remarkably similar to the definition ofg-measures, used in dynamical systems.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

In this thesis we classify the pairs (p,G), where p is a prime number and G is a finite p-group possessing an intense automorphism, i.e. an automorphism that sends each subgroup of G to a G-conjugate, that is non-trivial and whose order is coprime to p.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Predictive maintenance (PdM) is a maintenance policy that uses the past, current, and prognosticated health condition of an asset to predict when timely maintenance should occur.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Van 7-9 juni 2023 organiseert Global Transformations and Governance Challenges (GTGC) haar tweede internationale conferentie in Den Haag. Deadline voor inzendingen: 15 februari 2023.

Op dinsdag 2 mei 2017 is de H.A.Brasz scriptieprijs van de Vereniging voor Bestuurskunde uitgereikt aan Joanne Langkamp , als masterstudent afgestudeerd aan de Universiteit Leiden bij Joris van der Voet en Sandra Groeneveld. Joris van der Voet nam de prijs voor haar in ontvangst.

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…