Joery Matthys, universitair docent aan het Institute of Security and Global Affairs, bracht begin deze maand een ex ante evaluatie van het Contraterrorismebeleid uit.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

Promotor: Prof.dr. M. de Jong

Het ontwikkelen en demonstreren van innovatieve praktijken om met een lage milieu-impact farmaceutica te produceren.

A framework for prospective/ex-ante life cycle assessment (LCA) and ecological risk assessment (ERA) of emerging technologies is developed and applied to a case study of III-V/silicon photovoltaic panels.

Promotores: W. Jiskoot, F. Ossendorp

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

How do you make a technology sustainable that does not even exist yet? Well, by bringing together an interdisciplinary team of pioneering European experts right at the start and paying attention to sustainability right from the development phase.

Promotores: T.H.W. Bäck, Y. Tan, Co-promotor: M.T.M. Emmerich

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Promotie

What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotor: H.J. van den Herik, B.R. Katzy, Co-promotor: K. Sailer

Natuurkundigen hebben een astrofysisch neutrinosignaal van de IceCube detector bestudeerd vanuit een andere hoek. Het centrum van de Melkweg leek vanzelfsprekende de bron te zijn, maar deze hypothese is nu eerder verworpen dan bevestigd. Publicatie in Physical Letters B.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

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Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?

Promotor: W. Jiskoot, Co-promotor: A. Kros

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Cardiovascular syndromes are the major cause of death in Western societies.

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Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Op 13 oktober 2021 verdedigde Ross Spence het proefschrift 'Collateral Transactions and Shadow Banking'. Het promotieonderzoek is begeleid door promotoren prof.mr. M. Haentjens en prof.dr. A.M. Pacces (UvA).

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

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Op 5 juni verdedigde Maarten Aalbers het proefschrift 'De werking van algemene belangenafwegingen in het Europese staatssteunrecht: tussen verbod en verenigbaarheid?'. Het promotieonderzoek is begeleid door Pieter van Cleynenbreugel en Stefaan van den Bogaert.

Voor het eerst hebben wetenschappers het spoor van een hoogenergetisch neutrino uit de ruimte herleid tot zijn bron. Het is geproduceerd door een zogeheten blazar, een superzwaar zwart gat. Dat melden onderzoekers van neutrinodetector IceCube in Science. ‘Dit is een mijlpaal voor de neutrinoastronomie,’…

Waterstof kan het klimaatprobleem helpen oplossen. Tenminste, als we het op de juiste, schone manier gaan produceren. Leidse onderzoekers brachten de wereldwijde milieu-impact van waterstofproductie in kaart en keken vooruit tot 2050. Ze publiceerden hun werk in Energy & Environmental Science.

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Als onderzoekers hun data FAIR maken, kunnen computers grote hoeveelheden data koppelen en patronen herkennen waardoor onderzoekers veel sneller tot nieuwe inzichten kunnen komen. In Leiden, de bakermat van FAIR data, legt professor Barend Mons uit wat die term inhoudt.