Science Based Business (SBB) verbindt de domeinen wetenschap, bedrijfsleven en beleid. Wetenschappelijk onderzoek waar we ons in Leiden op richten, bijvoorbeeld op het gebied van kunstmatige intelligentie, belooft onze samenlevingen ten goede te komen. Het vertalen van wetenschap naar positieve maatschappelijke…

Promotor: Prof.dr. H.S. Overkleeft

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

In this project innovative technology for photovoltaics cells is developed and analysis of ecological and health related risks are explicitly accounted for.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Promotor: K.J. Batenburg

Promotor: Prof.dr. H.A.G. Wijshoff

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The aim of this thesis was to develop aluminium salt-based nanoparticles that may ultimately be used as adjuvant in human vaccines.

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Wat zijn de belangrijkste thema's in het uitvoeren van systemen voor bio-energie ?

Promotores: Wim Jiskoot; Ferry Ossendorp

This thesis describes the design, characterization and application of dextran based crosslinked network.

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

The work described in this thesis focuses on the development of linear or cyclized peptide probes against protein N-methyltransferases to characterize their specific binding behavior, providing further binding details for inhibitory activity study.

Promotor: Prof.dr. M. Danhof

In dit proefschrift wordt de samenwerking tussen studenten en resultaten in online projectgestuurd hoger onderwijs in China onderzocht.

Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet

Promotor: Prof.dr. J. Kuiper

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Meer informatie over dit onderzoeksproject vind je op de Engelstalige pagina.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

Onderzoekers van het Leiden Institute of Advanced Computer Science (LIACS) gaan een opleidingsprogramma ontwikkelen voor de volgende generatie van beginnende onderzoekers (ESR's). Gedurende een vierjarig project zullen zij worden opgeleid om industriële uitdagingen op een holistische manier te benaderen…

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Met dit project wordt onderzocht hoe docenten op drie internationale scholen zich gezamenlijk professionaliseren rond het thema ‘Inquiry based teaching’. Gegeven de rijkdom aan ervaring en achtergronden van de docenten op internationale scholen, kan worden verwacht dat docenten veel kunnen leren…

1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Over the last decades, aviation safety has improved strongly. As a downside, airline pilots do not have as many opportunities to develop through experience the competencies that they need in critical situations.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Promotor: Prof.dr. B.R. Katzy

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …

Promotores: W. Jiskoot, F. Ossendorp

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk