1,836 zoekresultaten voor “thijs works e2 80 99s discovery” in de Publieke website
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Thijs Bonenkamp
Faculteit Governance and Global Affairs
t.h.bonenkamp@fgga.leidenuniv.nl | +31 6 4810 5206
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Thijs Loggen
ICT Shared Service Centre
m.m.loggen@issc.leidenuniv.nl | +31 71 527 5731
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Thijs Lemaire
Faculteit Rechtsgeleerdheid
p.m.lemaire@law.leidenuniv.nl | +31 71 527 2727
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Thijs Aartsma
Wiskunde en Natuurwetenschappen
aartsma@physics.leidenuniv.nl | +31 71 527 5967
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Thijs Witty
Faculteit der Geesteswetenschappen
t.witty@hum.leidenuniv.nl | +31 71 527 2727
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Thijs Bierman
Wiskunde en Natuurwetenschappen
t.v.bierman@biology.leidenuniv.nl | +31 71 527 2727
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Thijs Hoogenboom
Wiskunde en Natuurwetenschappen
hoogenboom@physics.leidenuniv.nl | +31 71 527 1897
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Thijs Voskuilen
Wiskunde en Natuurwetenschappen
t.voskuilen@lic.leidenuniv.nl | +31 71 527 4516
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Thijs Buurman
ICT Shared Service Centre
t.m.buurman@issc.leidenuniv.nl | +31 71 527 2727
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Thijs Stockmans
Wiskunde en Natuurwetenschappen
stockmans@strw.leidenuniv.nl | +31 71 527 2727
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Modern Drug Discovery
How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…
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Drug Discovery & Safety
In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…
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Thijs Porck
Online scriptiebegeleiding
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Thijs Bos
Wiskunde en Natuurwetenschappen
j.m.bos@math.leidenuniv.nl | +31 71 527 2727
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MS@Work studie
Factoren van invloed op arbeidsparticipatie onder mensen met multiple sclerose
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Drug Discovery and Safety (MSc)
In deze opleiding ontwikkel je je onderzoek skills en verbreed je je kennis over de meest moderne en geavanceerde technieken die je nodig hebt als onderzoeker op het gebied van target finding en het ontwerp en de synthese van nieuwe geneesmiddelen.
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Thijs Bosker
Wiskunde en Natuurwetenschappen
t.bosker@cml.leidenuniv.nl | +31 71 527 4924
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Thijs Vos
Faculteit der Sociale Wetenschappen
t.j.vos@fsw.leidenuniv.nl | +31 71 527 2727
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Thijs Porck
Faculteit der Geesteswetenschappen
m.h.porck@hum.leidenuniv.nl | +31 71 527 1611
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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Michiel Thijssen
Wiskunde en Natuurwetenschappen
thijssen@physics.leidenuniv.nl | +31 71 527 2727
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Vivian Thijssen
Faculteit Rechtsgeleerdheid
v.thijssen@law.leidenuniv.nl | +31 71 527 2727
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Skip Thijssen
Wiskunde en Natuurwetenschappen
s.thijssen@liacs.leidenuniv.nl | +31 71 527 2727
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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Thijs van Veen
Universitair Facilitair Bedrijf
t.van.veen@ufb.leidenuniv.nl | +31 71 527 4231
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Thijs van Osch
Faculteit Geneeskunde
m.j.p.van_osch@lumc.nl | +31 71 526 9111
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Thijs van den Berg
Faculteit der Sociale Wetenschappen
t.s.van.den.berg@fsw.leidenuniv.nl | +31 71 527 2727
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Thijs Brocades Zaalberg
Faculteit der Geesteswetenschappen
t.w.brocades.zaalberg@hum.leidenuniv.nl | +31 71 527 2770
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Thijs van Dooremalen
Faculteit Governance and Global Affairs
t.j.a.van.dooremalen@fgga.leidenuniv.nl | +31 70 800 9500
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Thijs de With
ICT Shared Service Centre
j.m.de.with@issc.leidenuniv.nl | +31 71 527 2727
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Discovery of selective diacylglycerol lipase β inhibitors
Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
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Thijs van Kolfschoten
Faculteit Archeologie
t.van.kolfschoten@arch.leidenuniv.nl | +31 71 527 2640
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Thijs Jan van Schie
Faculteit der Sociale Wetenschappen
t.j.van.schie@fsw.leidenuniv.nl | +31 71 527 3451
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Kaare Strøm Award voor instituutslid Thijs Vos
Politicoloog Thijs Vos heeft deze zomer de Kaare Strøm prijs ontvangen voor zijn paper 'Power or Ideology? What structures legislative voting behaviour in Dutch municipal councils, ideology or coalition-opposition dynamics?'. Hij kreeg de prijs toegewezen tijdens de ECPR zomerschool over parlementen…
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Thijs de Boer
Faculteit Governance and Global Affairs
t.c.de.boer@fgga.leidenuniv.nl | +31 70 800 8206
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Causal Discovery from High-Dimensional Data in the Large-Sample Limit
Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets
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Discovery and characterization of new glucosylated metabolites: pathophysiological consequences
Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.
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Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…
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of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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Actors at work
Promotor: F.S. de Boer Co-promotor: P. T. de Gouw
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi