Lezing | Tuesday Talks: Science Insights
Tuesday Talks: Science Insights | 4 February 2025
- Datum
- dinsdag 4 februari 2025
- Tijd
- Bezoekadres
-
Gorlaeus Gebouw
Einsteinweg 55
2333 CC Leiden - Zaal
- CM1.26
Tuesday Talks: Science Insights is de maandelijkse dosis onderzoeksinspiratie van Leiden Science, van onze medewerkers, voor onze medewerkers en alle andere nieuwsgierigen.
De voertaal voor deze lezingenserie is Engels
Tailoring medicines for the genetically diverse African populations
Genetic differences in the expression and activity of drug metabolizing enzymes and transporters can lead to variable responses to treatment. This is in part because mutations in the genes encoding for drug metabolizing enzymes can lead to differences in rates of drug metabolism and thus in in vivo exposure.
Variations in drug response in African populations are not well accounted for despite African populations possessing greater genetic variation relative to other populations worldwide. Coupled with the generally low volume of clinical trials conducted in Africa and absence of African-centric preclinical discovery tools and models, this has contributed to the suboptimal efficacy and safety of some medicines used in African populations.
This lecture will describe strategies towards tailoring medicines for African populations taking into consideration their variable genetics.
Programme
The programme of the Tuesday Talks: Science Insights is:
| 15.30 hrs | Take a seat |
| 16.00 hrs | Tuesday Talks: Science Insights |
| 17.00 hrs | Drinks |
About the speaker
Kelly Chibale is a Professor of Organic Chemistry at the University of Cape Town (UCT) where he holds the Neville Isdell Chair in African-centric Drug Discovery & Development. He is also a Schmidt Sciences AI2050 Senior Fellow, Full Member of the UCT Institute of Infectious Disease & Molecular Medicine, founding Director of the South African Medical Research Council Drug Discovery & Development Research unit at UCT, Founder & Director of the UCT Holistic Drug Discovery and Development (H3D) Centre, and Founder & CEO of the H3D Foundation.
Kelly obtained his PhD in Synthetic Organic Chemistry from the University of Cambridge with Stuart Warren. This was followed by postdoctoral stints at the University of Liverpool with Nick Greeves and at The Scripps Research Institute with K.C. Nicolaou. He was a Sandler Sabbatical Fellow at the University of California San Francisco, a US Fulbright Senior Research Scholar at the University of Pennsylvania School of Medicine, and a Visiting Professor at Pfizer.
He serves as Editor-In-Chief of the American Chemical Society (ACS)’s ACS Medicinal Chemistry Letters.
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I will joinAbout Tuesday Talks: Science Insights
Tuesday Talks: Science Insights is Leiden Science’s monthly dose of research inspiration from our staff, for our staff and all others curious minds. Every second Tuesday of the month from 16:00 hrs till 17:00 hrs, drinks and meet up afterwards till 18.00 hrs.