2,389 zoekresultaten voor “mathematical and statistical modelling” in de Publieke website
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Promotie
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Modelling the role of mycorrhizal associations in soil carbon cycling
Promotie
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
Promotie
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Understanding the Heterogeneity of Corporate Entrepreneurship Programs
In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Evolutionary Developmental Biology of Bitterling Fish
We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…
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Going global to local: achieving agri-food sustainability from a spatially explicit input-output analysis perspective
The global agri-food system plays a critical role in food security and environmental issues.
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Revealing the nature of new low-frequency radio source populations
It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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Resolving the building blocks of galaxies in space and time
We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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Nature, nurture and neural mechanisms of social emotion regulation in childhood
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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Substances from Cradle to Grave
Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…
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Solving multiplication and division problems
Latent variable modeling of students' solution strategies and performance
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.
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representation: An experimental study on teacher-student gender congruence and students’ perceived abilities in math
Onderzoek naar representatieve bureaucratie heeft vaak de positieve prestatie-effecten bevestigd van bureaucratieën die de demografische kenmerken van hun cliënten weerspiegelen. Er is echter weinig bekend over de onderliggende mechanismen op individueel niveau die tot deze resultaten leiden.
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Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal
Op 16 december 2019 verdedigde Jan-Harm de Villiers zijn proefschrift 'The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal'. Het promotieonderzoek is begeleid door promotor prof.dr. P. Cliteur.
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Corporate venture management in SMEs: evidence from the German IT consulting industry
Promotor: Prof.dr. B.R. Katzy, Prof.dr. H.J. van den Herik, Prof.dr. G.H. Baltes (University of Applied Sciences Konstanz)
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Stap 4. Vergelijken en beslissen
Hoe maak je nu de definitieve keuze voor een masteropleiding?
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Morphodynamic equilibria in tidal inlet systems: sensitivity to geometrical variations
A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
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Evolution and development of orchid flowers and fruits
To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.
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Drie Leidse wetenschappers ontvangen NWO ENW-KLEIN subsidie voor vernieuwend onderzoek
De herkomst van Surinaamse rijst, een digitale tweeling van de aarde en een groot big-data project aan de Chileense hemel: drie Leidse wetenschappers ontvangen een ENW-KLEIN subsidie voor vernieuwend, fundamenteel onderzoek.
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Deze onderzoekers lossen met wiskunde medische problemen op
Twee Leidse wetenschappers laten zien hoe ze met wiskunde onze gezondheidszorg kunnen verbeteren. Daniel Gomon ontwikkelde een model om de kwaliteit van de zorg in ziekenhuizen te monitoren. Marta Spreafico werkt aan een app die artsen helpt bij de behandeling van een type kanker. ‘Het is geweldig wanneer…
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Prof.dr. Willem Heiser koninklijk onderscheiden
Hoogleraar psychologie Willem Heiser (statistische methoden en datatheorie) is op 31 januari 2014 benoemd tot Ridder in de Orde van de Nederlandse Leeuw. Na zijn afscheidsrede ontving hij de koninklijke onderscheiding wegens uitzonderlijke wetenschappelijke, maatschappelijke en bestuurlijk-organisatorische…
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NWO subsidie voor IOPS
Het 'Interuniversity Graduate School of Psychometrics and Sociometrics' (IOPS) heeft een bedrag van 800.000 euro toegekend gekregen van NWO voor het opleiden van jonge onderzoekers. Met de financiële impuls kan de onderzoeksschool vier beginnende onderzoekers de ruimte bieden om hun eigen ideeën te…
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Roland van der Veen ontvangt MAA Beckenbach Book Prize
Het boek ‘The Riemann Hypothesis: A Million Dollar Problem’ is door de Mathematical Association of America (MAA) beoordeeld als een van de beste wiskundeboeken. Op 13 januari ontvangen Leids universitair docent Roland van der Veen en co-auteur Jan van de Craats de MAA Beckenbach Book Prize voor dit…
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EuDEco Report on the legal analysis (D2.2)
D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…
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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
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Assessing the link between television consumption and the attitudes toward people living with HIV/AIDS in Chile
We analyse the link between media consumption and the attitudes toward people living with HIV/AIDS in Chile. We used data from a sample of 1000 people, obtained in the 2011 wave of the World Values Survey (WVS). We use a logistic binary regression model by maximum likelihood. Our results suggest that…
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Single-molecule microscopy in zebrafish embryos
Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.
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Lezingen bij Science
Van zwarte gaten tot kunstmatige intelligentie en van medicijnonderzoek tot data science: welkom in de fascinerende wereld van de Faculteit der Wiskunde en Natuurwetenschappen. Geregeld geven onze onderzoekers, studenten en gasten publieke lezingen over hun werk. U bent van harte uitgenodigd.
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Search for cosmic neutrinos with ANTARES
Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer
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Exploring the mechanisms of metastatic onset for novel treatment strategies
This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.
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Economie en transities: ongelijkheid, klimaat en globalisering
Analyse van maatschappelijke vraagstukken vanuit een economisch perspectief.
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Shekhar Kolipaka
Faculteit der Sociale Wetenschappen
s.s.kolipaka@fsw.leidenuniv.nl | +31 71 527 3451
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Gitta Veldt
Faculteit Rechtsgeleerdheid
g.m.veldt@law.leidenuniv.nl | +31 71 527 1093
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Simon Portegies Zwart
Wiskunde en Natuurwetenschappen
spz@strw.leidenuniv.nl | +31 71 527 8429
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Hans de Iongh
Wiskunde en Natuurwetenschappen
h.h.de.iongh@umail.leidenuniv.nl | +31 71 527 7461
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Ewine van Dishoeck
Wiskunde en Natuurwetenschappen
ewine@strw.leidenuniv.nl | +31 71 527 5814
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Lioe-Fee de Geus-Oei
Faculteit Geneeskunde
l.f.de_geus-oei@lumc.nl | +31 71 526 9111
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Onderzoek
Steden, Voedsel, Water, Biodiversiteit, Bronnen en Energie: dit zijn de belangrijkste onderzoeksthema’s voor het CML. Ons doel is altijd om wereldwijd voorop te lopen in ons vakgebied. En echte impact te hebben met onze onderzoeksprogramma’s.
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot