This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).

Promotor: T.H. Oosterkamp

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Promotor: M.A.G.J. Orrit

Binnen het Graduate Programme van Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) is de aanvraag voor de 'Netherlands Magnetic Resonance Research School' gehonoreerd. Deze onderzoeksschool is een van de 18 gehonoreerde aanvragen. Vier Leidse Graduate Schools zijn gehonoreerd.

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: M. Haverkorn

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Huub de Groot

To study how planetary systems come into existence we study much younger systems still in formation.

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

This thesis focuses on the study of transient and variable radio sources in the universe.

Make more fluid: In condensed matter systems, electrons can acquire unusual properties from their interaction with the atomic lattice.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

De hersenontwikkeling van kinderen met een extra X chromosoom in vergelijking met kinderen met idiopathisch autisme: inzicht vanuit MRI onderzoek

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

Veel neuropsychologen maken voor hun onderzoek gebruik van de hersenscanners in het LUMC. Toen de coronacrisis uitbrak werden de toegangseisen voor het ziekenhuis flink aangescherpt, en dreigde heel wat psychologisch onderzoek in de soep te lopen. Dankzij goede protocollen kunnen de onderzoekers nu…

Speciale versterkstoffen kunnen MRI-scanners honderden malen gevoeliger maken. Leidse fysici hebben nu een methode gevonden om hun efficiëntie te toetsen. Gevoeligere MRI-scans kunnen bijvoorbeeld taaislijmziekte of Parkinson begrijpelijker maken. Publicatie op 18 januari in PCCP.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: Prof.dr. C.U. Keller

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Promotor: S.M. Verduyn Lunel

Op vrijdag 25 mei is de oratie van Tjerk Oosterkamp over zijn leeropdracht 'Experimentele Natuurkunde'.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

Psycholoog Bernadet Klaassens heeft een groot fMRI-onderzoek opgezet naar het effect van medicijnen op hersennetwerken bij veroudering en de ziekte van Alzheimer. Het leverde een unieke dataset op en zicht op een nieuwe methode om medicijnen te ontwikkelen voor patiënten met Alzheimer.

Een nieuwe NMR-microscoop geeft natuurkundigen een verbeterd instrument om fundamentele fysische processen te onderzoeken. Het biedt ook nieuwe mogelijkheden voor de medische wetenschap, bijvoorbeeld om eiwitten beter te bestuderen in de hersenen van Alzheimerpatiënten. Publicatie in Physical Review…

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

NWO kent de titel Simon Stevin Meester 2017 toe aan Prof. Andrew Webb, hoogleraar MRI-fysica aan het LUMC en docent bij de opleiding natuurkunde in Leiden. Aan de prijs is een bedrag van 500.000 euro verbonden. Webb kan met dit bedrag nieuwe MRI-technieken ontwikkelen, waarmee je ziektes in een veel…

50 jaar geleden publiceerde Lauterburhet basisprincipe van MRI. Sindsdien is MRI steeds duurder geworden. Hoogleraar Andrew Webb beschrijft wat er nodig is om iedereen te laten profiteren van MRI.

Hoogleraar Radiologie Andrew Webb en zijn samenwerkingspartner Johnes Obungoloch uit Oeganda hebben de Huibregtsenprijs 2023 gewonnen.