The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Moritz Jesse has been awarded a Jean Monnet Chair by the European Commission. In his MIND-EU Project he will focus on a coherent way to teach Migration, Integration, and Non-Discrimination at Leiden Law School at bachelor and master level.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Rechtsgeleerdheid, Instituut voor Publiekrecht, Grotius Centre for International Legal Studies

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Promotie

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

De Société Francaise d’Optique (SFO) heeft de winnaars bekend gemaakt van haar tweejaarlijkse Grand Prix SFO Léon Brillouin. Professor Michel Orrit van het Leiden Institute of Physics (LION) is een van de twee mensen die dit jaar deze eer mogen ontvangen.

Promotor: J. A. Bouwstra

Hendrik Lenstra was een van de wiskundigen die het Droste-effect in M.C. Eschers tekening

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

De rechter heeft een streep door het besluit van Kabinet gezet om Schiphol te laten krimpen. Terecht, zegt emeritus hoogleraar Lucht- en Ruimterecht Pablo Mendes de Leon.

De Arts and Humanities Research Council (AHRC) in samenwerking met NWO heeft aan Leon Wainwright (The Open University, UK) en Kitty Zijlmans een subsidie toegekend voor hun netwerk- en uitwisselingsprogramma ‘Sustainable Art Communities: Creativity and Policy in the Transnational Caribbean’.

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

This thesis introduces the concept of

Professor Barend Mons has been appointed Chair of the Commission High Level Expert Group

Prof.dr. Léon Buskens (directeur NISIS en LUCIS) heeft samen met prof.dr. Thijl Sunier (VU) een NWO-beurs ontvangen voor hun onderzoeksvoorstel “Making Islam Work in the Netherlands. Islamic Authority and Islamic Law in the Netherlands among Ordinary Muslims: Recent Trends and Developments.” Dit onderzoek…

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Het is onderzoekers voor het eerst gelukt grafeen op een stabiele laag vetten, ofwel lipiden, te plaatsen. Omringd door een beschermende laag van lipiden zou grafeen in het lichaam als een veelzijdige sensor kunnen dienen. De resultaten zijn de eerste stap naar zo’n omhulsel en zijn op 28 september…

Heart failure is a major health care problem with high mortality.

Promotor: A. Kros