147 zoekresultaten voor “cryo-electron microscopy” in de Publieke website
-
Quantum Matter and Optics
Onderzoeksgroepen in het Quantum Matter & Optics onderzoeksprogramma onderzoeken elektronische eigenschappen van interacties van materie en lichtmaterie, met de nadruk op quantuminformatie.
-
Nieuwe transmissiemicroscoop voor elektronen met lage energie
Natuurkundige Daniël Geelen ontwikkelde tijdens zijn promotie een nieuwe microscoop die laag-energetische elektronen gebruikt. Zulke elektronen zijn minder schadelijk voor biologische en organische materialen. Geelen promoveert op 31 mei.
-
Understanding the Surface Structure of Catalysts and 2D Materials at the Atomic Scale
The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.
-
Nieuwe behandelingen om spierziektes te bestrijden
Biofysicus Alireza Mashaghi gaat samen met zijn collega’s de strijd aan tegen spierdystrofie: genetische aandoeningen die spierziektes veroorzaken. Ze zijn op zoek naar een oplossing voor het samenklonteren van eiwitten, waarbij gevaarlijke ophopingen ontstaan. Het team ontvangt hiervoor 550.000 euro…
-
Platinum electrochemistry through a magnifying glass
In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.
-
Low energy electron transmission through layered materials and chiral organic films
In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…
-
Single-molecule microscopy in zebrafish embryos
Promotie
-
Functional fluorescent materials and migration dynamics of neural progenitor cells
In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.
-
Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
-
Microcoil MRI of Plants and Algae at Ultra-High Field: An exploration of metabolic imaging
This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).
-
Gold nanoparticle-peptide conjugates for biomedical applications
Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.
-
Insights into microtubule catastrophes: the effect of end-binding proteins and force
For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.
-
Optoplasmonic detection of single particles and molecules in motion
Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.
-
Insights from scanning tunneling microscopy experiments into correlated electron systems
Promotie
-
Natuurkundige Michel Orrit nieuw lid KNAW
De Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) kiest haar leden uit een select gezelschap van vooraanstaande onderzoekers. Op 17 september installeert de KNAW 21 nieuwe leden, waaronder Leids natuurkundige Michel Orrit.
-
Photothermal circular dichroism studies of single nanoparticles
In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.
-
Michel Orrit en Hermen Overkleeft lid KNAW
De Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) kiest haar leden uit een select gezelschap van vooraanstaande onderzoekers. Op 17 september installeert de KNAW 21 nieuwe leden, onder wie Leids natuurkundige Michel Orrit en chemicus Hermen Overkleeft.
-
Biological model representation and analysis
Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek
-
Huub de Groot
Wiskunde en Natuurwetenschappen
groot_h@chem.leidenuniv.nl | +31 71 527 4539
-
Science Friction (SciFri)
Hoe kan wrijving op de nanoschaal gereduceerd worden?
-
Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
-
A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
-
Using cryo-EM methods to uncover structure and function of bacteriophages
Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.
-
Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
-
Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
-
Water related adsorbates on stepped platinum surfaces
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
-
Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
-
Photon detection at subwavelength scales
Promotor: Prof.dr. E. Eliel, Co-Promotor: M.J.A. de Dood
-
The environmentally-regulated interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
-
Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
-
Network flow algorithms for discrete tomography
Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele
-
Giant unilamellar vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
-
Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
-
The electrode-electrolyte interface in CO2 reduction and H2 evolution: a multiscale approach
Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.
-
De blinde microscoop: van MRI op de nanoschaal tot academische vorming
Op vrijdag 25 mei is de oratie van Tjerk Oosterkamp over zijn leeropdracht 'Experimentele Natuurkunde'.
-
Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
-
Evolution and development of flowers, fruits and inflorescences of Phalaenopsis and other orchid species
The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.
-
Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
-
Quantumnetwerken en quantumsensing
Binnen Quantum Leiden doen verschillende groepen onderzoek naar quantumnetwerken en quantumsensing.
-
Student projects
To get an idea of the science communication products and research that is possible, a few examples of student projects of recent years are shown below.
-
Synthetic, Physical and Computational Chemistry of Propeller-shaped Polycyclic Aromatic Hydrocarbons
This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…
-
Stable single molecules for quantum optics and all-optical switches
Promotor: Prof.dr. M.A.G.J. Orrit
-
Isolerend verschijnsel in supergeleider
Leids natuurkundige Milan Allan en zijn groep hebben een schijnbare paradox ontdekt in een materiaal met nul elektrische weerstand. Ze maten opgesloten ladingen, terwijl ladingen in theorie altijd blijven stromen in afwezigheid van weestand. De ontdekking kan een ontbrekend puzzelstukje zijn in een…
-
Onderzoek
Onderzoekers vanuit verschillende vakgebieden werken samen om oplossingen te bedenken voor maatschappelijke problemen.
-
Development of an Adverse Outcome Pathway (AOP) for metallic nanoparticles
What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?
-
Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
-
Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
-
De magie van vloeibaar helium: deze persoon maakt ijskoud onderzoek in Leiden mogelijk
Witte wolken ijskoud gas die over de vloer stromen. Magisch, maar ook uitkijken dat je vingers er niet afvriezen. We hebben het natuurlijk over vloeibaar stikstof en helium. Misschien heb je de spectaculaire Freezing Physics-wetenschapsshow van de studentenorganisatie Stichting Rino weleens gezien.…
-
Helder beeld van bacteriën
Een bacterie supersnel bevriezen, om de structuur van buiten en binnen natuurgetrouw in beeld te brengen. Hoogleraar Ultrastructuurbiologie Ariane Briegel kwam speciaal hiervoor naar Leiden: de Universiteit Leiden is een van de weinige instituten wereldwijd waar de benodigde apparatuur beschikbaar is.…
-
What a glow in the dark squid tells us about the human gut microbiome
Lezing, Tuesday Talks: Science Insights