844 zoekresultaten voor “cancer drug resistance” in de Publieke website
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Klein molecuul gaat uitzaaien tumorcellen tegen
Leidse chemici wisten met collega’s in York en Israël een molecuul te maken dat de weefselstructuur om een tumor heen steviger houdt. Zo kunnen losse tumorcellen niet zo makkelijk uitzaaien. De onderzoekers hebben al patent op het molecuul aangevraagd, maar gebruik hiervan bij patiënten is nog onzeker.…
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Archief
Op deze pagina vindt u de opnames van de online This Week's Discoveries vanaf 12 mei 2020 en een lijst sprekers vanaf oktober 2015.
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Promoveren aan twee universiteiten op drugsmisbruik
Stimulerende drugs als khat en cocaïne hebben negatieve impact op dagelijkse handelingen als autorijden, werk of sociaal gedrag. Dat komt door beschadiging van controlefuncties in de hersenen. Psycholoog Manuel Ruiz draagt bij aan beter begrip en behandeling van drugsmisbruik. De Spanjaard Ruiz promoveert…
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The role of glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Nanoparticle-based combination drug delivery systems for effective cancer treatment
Promotie
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink
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The ecological relevance of chemical diversity in plants
Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder
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Marcellus UbbinkWiskunde en Natuurwetenschappen
m.ubbink@chem.leidenuniv.nl | +31 71 527 4628
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Samenwerken voor efficiënte medicijnontwikkeling
De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…
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Multilayer cancer glycomis
Promotie
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Lighting Up Cancer Aggressiveness
Promotie
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Radiotherapy for endometrial cancer
Promotie
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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The role of the tumor suppressor Lkb1 in energy homeostasis
The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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Medical Delta café: translation models for drug discovery and development, 8 oktober 2013
Onze gemiddelde leeftijd gaat omhoog en de behoefte naar goede gezondheidszorg wordt steeds groter. Nieuwe medicijnen moeten op de markt komen maar kosten voor de ontwikkeling daarvan moeten omlaag. Tijdens het Medical Delta café op 8 oktober presenteren o.a. dr. Leo Price, dr. Jan de Sonneville en…
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Stromal immunobiology in gastrointestinal cancer
Promotie
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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Tumoren trekken bloedvaten aan met ‘afstandsbediening’
Onderzoekers van de Universiteit Leiden hebben aangetoond dat tumoren op een mechanische manier bloedvaten kunnen aantrekken, waardoor ze kunnen groeien. Het team publiceerde deze ontdekking op 2 maart in Nature Scientific Reports.
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Videocollege: Wat is kanker precies?
Kanker is nog altijd een van de meest voorkomende ziektes in de wereld. In een video van de Universiteit van Nederland legt Noel de Miranda (kankerimmunologie, LUMC) uit wat kanker is en vertelt over zijn onderzoek naar nieuwe behandelingen.
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Roxanne KieltykaWiskunde en Natuurwetenschappen
r.e.kieltyka@chem.leidenuniv.nl | +31 71 527 4441
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Mario van der SteltWiskunde en Natuurwetenschappen
m.van.der.stelt@chem.leidenuniv.nl | +31 71 527 4768
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EGFR inhibitors in colorectal cancer
Promotie
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Semisynthetic glycopeptide antibiotics
Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.
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Women Writing Mexico (WWM)
Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…
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Immuunsysteem speelt dubbele rol bij borstkanker
Het immuunsysteem speelt een paradoxale rol bij de uitzaaiing van borstkanker. Dat ontdekte Kelly Kersten in haar promotieonderzoek. Sommige immuuncellen dragen bij aan uitzaaiingen, terwijl andere cellen kunnen worden aangezet om chemotherapie effectiever te maken. Promotie op 7 februari.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Targeting SUMO Signaling to Wrestle Cancer
Promotie
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The path to individualised breast cancer screening
Promotie
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Raman Spectroscopy in Bladder Cancer Diagnosis
Promotie
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Monitoring Outcomes In Colorectal Cancer Surgery
Promotie
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Glycoproteomics assays for prostate cancer biomarker discovery
Promotie
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Identification of regulators of cancer - immune interactions
Promotie
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Dissecting the immune microenvironment of breast cancer
Promotie
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Lateral Lymph Nodes in Rectal Cancer
Promotie
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Formulation of Peptide-Based Cancer Vaccines
Promotie
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ASCL Seminar: Roadblock Politics - Predation and Resistance in Central Africa
Lezing
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Tailored treatment for colon and rectal cancer
Promotie
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Genetic and lifestyle factors in breast cancer prognostication
Promotie