Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

Promotor: G.R. de Snoo

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

In this Ph.D. thesis we study the interaction of low energy electrons with thin materials, namely layered materials (graphene, hexagonal boron nitride, molybdenum disulfide) and organic films. At these low energies the quantum mechanical wavelength of the electron wave function is in the order of a…

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

Promotor: H.V.J. Linnartz

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Promotor: Prof.dr. G.P. van Wezel

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…

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This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

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In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

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Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

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Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Met de NMR faciliteit doen we onderzoek naar de synthese van paramagnetische moleculen om kennis te vergaren over de structuur en dynamiek van eiwitten. Deze kennis kan dienen als basis voor een medicijn dat zich hecht aan een eiwit of voor de ontwikkeling van vaccins. Medicijnontwikkeling is één van…

Promotor: M.A.G.J. Orrit

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

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Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

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Integratie van MOOC in campus

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

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This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

De gratis online academische cursussen van de universiteit zijn voor iedereen over de hele wereld te volgen.

Met ingang van 1 april is Ewa Snaar-Jagalska benoemd tot hoogleraar Cellulaire tumorbiologie aan het Instituut voor Biologie, onderdeel van de Universiteit Leiden.