Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotor: Prof.dr. J.N. Kok

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Promotor: Prof.dr. J. Kuiper

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

The development of new environmentally sound technologies is seen as a key route towards achieving sustainability.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

Promotor: B.van de Water, Co-promotor: L.S.Price

This programme aims to make the digitized archival sources of the Kerala and Tamil Nadu Archives more accessible to Indian and international scholars and to the widest possible audience, in particular to the people of Kerala.

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

Er bestaan mogelijkheden om als gastonderzoeker aan te sluiten bij het initiatief en tijd door te brengen in residentie bij GTGC in Den Haag. Mocht u interesse hebben, neem dan gerust contact met ons op. Hieronder vindt u onze huidige gastonderzoeker(s).

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

Op 11 juni 2020 verdedigde Sabine Witting haar proefschrift 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. Het promotieonderzoek is begeleid door promotoren prof.mr. J.J. Sloth-Nielsen en prof.dr.mr. S. van der Hof.

Het Leiden Leadership Centre verbindt wetenschap en praktijk door evenementen over publiek leiderschap te organiseren – zoals Leiden Leadership Lunches, webinars, (internationale) conferenties en de Leiden Leadership Podcast.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)

What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?

Promotor: G.A. Persoon, Co-promotor: H.H. de Iongh

What is movements and corridors of the Bornean pygmy elephant in Sebuku forest? What is the nature of human-elephant conflict in Nunukan District in time and space? What are the diets of the Bornean elephants related to crop raiding?

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?

World Teachers Festival 2024 - Celebrating and exploring language, culture, diversity and criticality in teaching and learning

LIACS is a partner in the EU Erasmus+ Curriculum Development for the Asian education system. The knowledge available in the field of Data Science and Artificial Intelligence education will be shared and adapted for the Asian market.

Are there significant differences among the environmental impacts resulting form the production of Asian aquaculture commodities and what are the main causes for these?