Nature, nurture and neural mechanisms of social emotion regulation in childhood

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Kunst en vrije tijd, Kunst en vrije tijd

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotie

Promotie

Welke factoren (mens-dimensie en carnivoor-gerelateerd) zijn bepalend voor de menselijke tolerantie ten opzichte van grote carnivoren en voor de overlevingskansen van grote carnivoren in bossen met meervoudig gebruik?

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Een bachelor Security Studies doen en tegelijkertijd twee bedrijven opzetten en runnen: student Mohamed Sulaiman is altijd aan het werk. Maar dat doet hij met plezier en toewijding. Bij ondernemershub PLNT Den Haag krijgt hij hulp en doet hij inspiratie op.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Graduation MIRD Class of 2024: 'The world is better off with students like this'

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

This thesis discusses the discovery potential of Intensity Frontier experiments.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Promotie

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Promotie

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.

Studievoorlichting

Studievoorlichting

Studievoorlichting

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.

One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.

Animal diet studies are critical for understanding ecological processes such as trophic interactions, energy flow, and nutrient cycling. By examining what animals consume, ecologists gain insights into species specialization, predator-prey relationships, and ecosystem management.

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Promotor: A. Kros

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotor: Prof.dr. M.L. van Hecke

My work focuses on a class of astronomical objects called protoplanetary disks.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Promotie

Promotie

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

Electrons in a crystal lattice have properties that may differ from those of a free electron in vacuum.

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.