Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Om je aan te melden voor de bacheloropleiding Molecular Science and Technology heb je meerdere documenten nodig. Zorg ervoor dat je deze documenten bij de hand hebt.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

What is the mechanism of action preceding a physiological effects induced by metallic nanoparticles?

During the course of drug discovery translational steps are made.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

Promotor: M.T.M. Koper, Co-promotor: L. Juurlink

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Promotor: Prof.dr. M. Ubbink

Promotor: Prof.dr. J.P. Abrahams

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Studievoorlichting

Studievoorlichting

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

Promotie

Promotie

Promotie

Voor Molecular Science and Technology is de matchingsactiviteit een verplicht onderdeel van de inschrijving.

Wil jij de beste redenen weten waarom je aan de Universiteit Leiden moet studeren? Of hoe het is om te leven in studentensteden zoals Leiden of Den Haag? Onze studenten vertellen je over hun studie aan de Universiteit Leiden.

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

Wil jij de beste redenen weten waarom je aan de Universiteit Leiden moet studeren? Of hoe het is om te leven in studentensteden zoals Leiden of Den Haag? Onze studenten vertellen je over hun studie aan de Universiteit Leiden.

Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Planets are formed in disks of gas and dust around young stars.

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Het Natuurwetenschappelijk Gezelschap Leiden heeft haar succes mede te danken aan de diverse besturen die de lezingen, vergaderingen en activiteiten van het gezelschap hebben verzorgd.

The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).