1,117 zoekresultaten voor “stem cell biology” in de Publieke website
-
Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
-
Horizon2020-subsidie voor toxicoloog Bob van de Water
Een internationaal onderzoeksconsortium onder leiding van Bob van de Water, hoogleraar Toxicologie van de Universiteit Leiden, heeft een prestigieuze Horizon2020-subsidie van 30 miljoen euro ontvangen.
-
Van Vonno, Achieving Party Unity: A Sequential Approach to Why MPs Act in Concert (dissertatie)
Cynthia van Vonno, politicoloog aan de Universiteit Leiden, verklaart in haar proefschrift waarom individuele parlementariers meestemmen met hun fractie.
-
Ahmed Mahfouz: 'Het mysterie van hersenziekten, cel voor cel uitgezocht'
Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.
-
In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
-
Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
-
PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
-
Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
-
Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
-
Key innate immune components controlling intracellular infection
Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer
-
The ecological relevance of chemical diversity in plants
Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder
-
Synthesis of chemical tools to study the immune system
This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.
-
Understanding the uptake and internal distribution of metallic nanoparticles in Danio rerio larvae
The aim is to discover where differently shaped metal nanoparticles distributes in Danio rerio, linking the distribution with genomic responses and so come up with a Mode of Action.
-
The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
-
Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
-
The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
-
Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
-
Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
-
Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
-
Systems vaccinology: molecular signatures of immunity to Bordetella pertussis
Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz
-
The dynamic organization of prokaryotic genomes: DNA bridging and wrapping proteins across the tree of life
Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.
-
Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
-
Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
-
Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom
-
Nanofluidic tools for bioanalysis : the large advantages of the nano-scale
Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)
-
Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
-
Platinum electrochemistry through a magnifying glass
In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.
-
Synthesis of Ribitol Phosphate based Wall Teichoic acids
Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.
-
Unraveling the auxin mechanism in 2,4-D induced somatic embryogenesis in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa
-
Surface Temperature and the Dynamics of H2 on Cu(111)
Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…
-
Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
-
PLGA-based particulate vaccine delivery systems for immunotherapy of cancer
Promotores: W. Jiskoot, F. Ossendorp
-
The advantages and disadvantages of bioorthogonal proteins
This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.
-
Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
-
Single-molecule fluorescence in sequence space
The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…
-
De Ethiopische wolf: gerespecteerd én bedreigd door lokale veehouders
De zeldzame Ethiopische wolf komt steeds vaker in aanvaring met lokale veehouders. Promovendus Girma Eshete zocht naar manieren om het elegante beest te redden van de ondergang. Promotie op 5 september.
-
Onderzoekers stellen met kloppende 3D-minihartjes oorzaak hartspierziekte vast
Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) zijn erin geslaagd om een minihartje te kweken met volwassen kloppende hartcellen. Ze laten met dit model zien dat een genetische fout in de bindweefselcellen medeverantwoordelijk is voor de hartspierziekte aritmogene cardiomyopathie (ACM).…
-
vulnerabilities induced by recurrent mutations in chondrosarcoma and giant cell tumour of bone
Promotie
-
Beschrijvende taalkunde
Het documenteren en beschrijven van de talen van de wereld.
-
Explaining Government–Opposition Voting in Parliament
Er is nogal wat variatie in de mate waarin parlementaire stemmingen verlopen volgens de scheidslijn regering-oppositie. Hoe zijn deze verschillen te verklaren? Party Politics artikel van Tom Louwerse et al.
-
Wil Tamis
Wiskunde en Natuurwetenschappen
tamis@cml.leidenuniv.nl | +31 71 527 2727
-
Hermen Overkleeft
Wiskunde en Natuurwetenschappen
h.s.overkleeft@chem.leidenuniv.nl | +31 71 527 5037
-
Esther van der Ent
Wiskunde en Natuurwetenschappen
e.van.der.ent@cml.leidenuniv.nl | +31 71 527 2727
-
Universitaire verkiezingen
Dit jaar zijn er verkiezingen voor de studenten- en personeelsgeleding van de Universiteitsraad en de studentengeleding van alle faculteitsraden. Jij bepaalt wie jou mag vertegenwoordigen bij de bestuurders van onze universiteit. Welke thema’s en standpunten vind je belangrijk? Met jouw stem heb je…
-
Waardoor groeit een plant naar het licht?
Zet een plant in de vensterbank en hij zal binnen enkele uren naar het licht gegroeid zijn. Voor het eerst is dit mechanisme in planten op moleculair niveau in kaart gebracht door Leidse biologen en onderzoekers uit Gent en Lausanne. Ze publiceerden hierover in het prestigieuze Nature Cell Biology.
-
Systems biology as a compass to understand cancer-immune interactions in humans
Promotie
-
The T cell-myeloid axis in the success and failure of cancer immunotherapy
Promotie
-
Molecular approaches to identify cancer T cell antigens and improve immunogenicity
Promotie
-
unchained; molecular mechanisms of ubiquitin-like signal transduction in cell cycle progression
Promotie
-
Biomarkers for the response to immunotherapy in patients with non- small cell lung cancer
Promotie