1,087 zoekresultaten voor “development disease” in de Publieke website
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Targeting autoimmunity in renal diseases: focus on neutrophil extracellular traps and autoreactive B-cells
Promotie
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Advanced tools and methods for modeling cardiovascular disease using human pluripotent stem cells
Promotie
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Genetic and clinical pharmacology studies in GBA1-associated Parkinson's disease
Promotie
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Multi-modality imaging in ischemic heart disease, arrhythmia and cardiac-mechanics
Promotie
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Based Pituitary Care, implementing Value Based Health Care in a rare disease
Promotie
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Optimising neonatal management of haemolytic disease of the foetus and newborn
Promotie
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closer look: Non-invasive tools for in-depth characterisation of vulvar diseases
Promotie
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Nieuw project om ziekte van Alzheimer te bestuderen
Onderzoekers van de Universiteit Leiden gaan een nieuwe manier ontwikkelen om de biomarkers van de ziekte van Alzheimer te bestuderen. De aanpak focust zich op de moleculaire boodschappers van de cellen. Het project, geleid door Thomas Hankemeier en gecoördineerd door Yuliya Shakalisava (Leiden Academic…
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Targeting of antigen-presenting cells with mannosylated conjugates
This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.
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elderly in clinical trials: how to define preclinical Alzheimer’s Disease for clinical trial participation
Promotie
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Remodeling, Myocardial Function and Risk Stratification in Cardiovascular Disease
Promotie
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autoantibody-positive and autoantibody- negative rheumatoid arthritis during the disease course
Promotie
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microbiota transplantation and dietary interventions in Inflammatory Bowel Disease; efficacy and challenges for the future
Promotie
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A joint evaluation of local and systemic disease activity in treated-to- target rheumatoid arthritis
Promotie
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Europa en de sociaal-economische kracht van astronomie
Het European Regional Office of Astronomy for Development (E-ROAD) heeft zijn eerste conferentiesessie gehouden tijdens de virtuele EAS Annual Meeting 2020, de grootste astronomieconferentie in Europa. E-ROAD is een initiatief van de Internationale Astronomische Unie en de Universiteit Leiden. Het zet…
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SCS Courses
The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Iber Kasehatan in Sukamiskin: Utilisation of the Plural Health Information and Communication System in the Sunda Region of West Java, Indonesia
This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.
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Specifiek eiwit in de hoofdrol bij ziekte van Parkinson
Met elektronspins hebben natuurkundigen het bindingsproces onderzocht van het eiwit α-synucleïne, dat wordt geassocieerd met de ziekte van Parkinson. Wat blijkt is dat het eiwit op een verrassend efficiënte manier bindt aan een hersenmembraan. Met deze in Leiden ontwikkelde methode hebben de onderzoekers…
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Preclinical therapy development in FSHD
Promotie
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Toelatingseisen
De masteropleiding Education and Child Studies is een academische opleiding en biedt op onderzoek gebaseerde kennis over leren en de ontwikkeling van kinderen.
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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Education and Child Studies (MSc)
In de masteropleiding Education and Child Studies kies je een specialisatie in één van de deeldisciplines van de pedagogische wetenschappen. In alle specialisaties staat de wetenschappelijke vorming van studenten voorop.
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Electrical and magnetic properties of ferritin: electron transport phenomena and electron paramagnetic resonance
Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh
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LUMC-hoogleraar krijgt prijs op Zeldzame Ziektendag
Prof. Judith Bovée kreeg zaterdag een prijs uitgereikt op Zeldzame Ziektendag. De prijs is een blijk van waardering vanuit de gezamenlijke patiëntenverenigingen voor haar wetenschappelijk en diagnostisch werk op het gebied van zeldzame bottumoren.
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Regulation of autophagy-related mechanisms during bacterial infection
Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.