3,339 zoekresultaten voor “high throughput screening and microscopy” in de Publieke website
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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High-throughput quantification and unambiguous identification for metabolomics
The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Innovative sample preparation and handling strategies for automated and high-throughput metabolomics
Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…
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Josephson and noise scanning tunneling microscopy on conventional, unconventional and disordered superconductors
In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…
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Magnetic Resonance Force Microscopy and the Spin Bath
There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.
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Biological model representation and analysis
Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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Light and Electron Microscopy Facility
Het doel van deze faciliteit is om het biomedisch onderzoek te versnellen door toegang te bieden tot geavanceerde licht- en elektronenmicroscopie en door het delen van expertise over monstervoorbereiding, beeldvormingsmodaliteiten, gegevensopslag en beeldanalyse.
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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High-throughput simulation studies of angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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Microscopy Unit
De Microscopy Unit huisvest, onderhoudt en coördineert vrijwel alle microscopieapparatuur van het IBL. De beschikbare apparatuur varieert van conventionele licht- en fluorescentiemicroscopen tot confocale laser- en elektronenmicroscopen. Er is bovendien apparatuur beschikbaar voor histologie, met inbegrip…
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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Single-molecule microscopy in zebrafish embryos
Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.
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Low-Energy Electron Microscopy on Two-Dimensional Systems: Growth, Potentiometry and Band Structure Mapping
Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Lasers, lenses and light curves: adaptive optics microscopy and peculiar transiting exoplanets
Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen
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Advances in SQUID-detected Magnetic Resonance Force Microscopy
In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).
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Transmission electron microscopy on live catalysts
The dissertation describes TEM experiments on heterogeneous catalysts.
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eV-TEM: Transmission Electron Microscopy with few-eV Electrons
Electron microscopy has become an extremely important techniquein a wide variety of elds.
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mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Insights from scanning tunneling microscopy experiments into correlated electron systems
This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Probing quantum materials with novel scanning tunneling microscopy techniques
This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.
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Design and development of a comprehensive data management platform for cytomics: cytomicsDB
Promotor: Prof.dr. J.N. Kok
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Magnetic resonance force microscopy for condensed matter
In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.
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Microcoil MRI of Plants and Algae at Ultra-High Field: An exploration of metabolic imaging
This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).
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Nuclear magnetic resonance force microscopy at millikelvin temperatures
Promotor: T.H. Oosterkamp
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Superlattices in van der Waals materials: A Low-Energy Electron Microscopy study
n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.
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High-contrast imaging polarimetry of exoplanets and circumstellar disks
Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.
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Disorder and interactions in high-temperature superconductors
This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.
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Empirical Bayes applications in biomedical high-dimensional prediction
The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.
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High-Contrast Imaging of Protoplanetary Disks
To study how planetary systems come into existence we study much younger systems still in formation.
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High-contrast spectroscopy of exoplanet atmospheres
More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.
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Vertebrate automated screening technology (VAST)
Hoe kun je met robots en automatische herkenning van microscopische beelden uitzonderlijk snel het effect van medicijnen testen?
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pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
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Efficiëntere geneesmiddelenontwikkeling met hulp van computermodellen
Het coronavirus heeft de wereld in zijn greep. Het vinden van een medicijn is nog nooit zo belangrijk geweest. Helaas zijn de ontwikkeling van nieuwe medicijnen en de ontwikkeling van een vaccin complexe, langdurige en vooral kostbare processen. Computermodellen kunnen dit proces versnellen. Wetenschappers…
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Prior information and variational Bayes in high dimensional statistical network inference
This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).
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Feedback from deeply embedded low- and high-mass protostars. Surveying hot molecular gas with Herschel
Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Single-molecule fluorescence in sequence space
The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…
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Towards High Performance and Efficient Brain Computer Interface Character Speller: Convolutional Neural Network based Methods
A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…