1,098 zoekresultaten voor “single molecule spectroscopy” in de Publieke website
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the AGN environment: new perspectives from high-resolution X-ray spectroscopy
Promotor: J.S. Kaastra Co-promotor: E. Constantini
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Molecules during stellar formation and death
Promotor: Prof.dr. E. F. van Dishoeck
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X-ray spectroscopy of interstellar dust: from the laboratory to the Galaxy
In this thesis, we present new laboratory data of interstellar dust analogues.
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Ab initio molecular dynamics calculations on reactions of molecules with metal surfaces
Promotor: Prof.dr. G.J. Kroes
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Optical properties of DNA-hosted silver clusters
Promotor: D. Bouwmeester, Co-promotor: D. Kraft
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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Unravelling cell fate decisions through single cell methods and mathematical models
Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.
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The formation of complex organic molecules in dense clouds-Sweet results from laboratory
Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.
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Spinozapremie voor hoogleraar Spectroscopie Michel Orrit
Mede dankzij de Leidse hoogleraar Michel Orrit is het tegenwoordig mogelijk om losse moleculen te bestuderen. Hij liep de Nobelprijs net mis, maar wordt nu alsnog gelauwerd met een belangrijke wetenschappelijke onderscheiding. Op 16 juni ontvangt hij de Spinozapremie van NWO.
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.
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Structural Properties of Single Server Queueing Systems: Efficient Methods via Lumping and Dynamic Programming
This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Charge transport properties of Ru-complex molecules: the influence of humidity
I will give a general introduction to the field of molecular electronics, its history, methods and challenges. I will also introduce the subject of my investigation and provide a brief outlook to the remainder of our thesis.
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Highly Accurate Simulations and Benchmarking of Molecule-Surface Reactions
Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.
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NMR structural studies of protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Dark ice chemistry in interstellar clouds
This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.
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Beyond the Born-Oppenheimer Static Surface Model for Molecule- Surface Reactions
Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.
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Adsorption and catalysis on Pt and Pd monolayer-modified Pt single crystal electrodes
The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.
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Losse moleculen tonen belofte om losse elektronen te zien met licht
Het is nog nooit gelukt om een enkel elektron te detecteren met zichtbaar licht via slechts één molecuul. Leids natuurkundige Michel Orrit en zijn onderzoeksgroep hebben nu een molecuul geïdentificeerd dat gevoelig genoeg is om een elektron te detecteren op een afstand van honderden nanometers. De resultaten…
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Small molecule inhibitors of Nicotinamide N-Methyltransferase (NNMT)
NNMT wordt beschouwd als een nieuw potentieel farmacologisch doelwit in de behandeling van een verscheidenheid van kankers, stofwisselingsziekten en andere pathologieën. Het toenemend aantal publicaties waarin de rol van NNMT bij ziekten wordt opgehelderd, heeft op zijn beurt de ontwikkeling van krachtige…
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the structure and chemistry of planetary birthplaces with simple molecules
This thesis examines the link between simple molecules and the underlying structure and chemistry within protoplanetary disks - the birthplaces of planets.
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Exploring charge transport properties and functionality of molecule-nanoparticle ensembles
Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen
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Hot Nanoparticles
Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.
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Atmospheres of hot alien Worlds
Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Van moleculen naar planeten: Verkennen van de chemische erfenis van zonnestelsels
Walsh
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Nagemaakte moleculen verraden verstopmethode van bacteriën
Dankzij bepaalde vet-suikermoleculen kunnen onder meer leprabacteriën zich verstoppen voor ons immuunsysteem. Hoe precies, is niet helemaal duidelijk. Hessel van Dijk, die op 13 oktober promoveerde, maakte de moleculen na en hielp daarmee een stukje van de puzzel op te lossen. Van Dijks proefschrift…
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Enkel molecuul gedetecteerd voor gebruik in kwantumnetwerk
Leidse fysici zijn erin geslaagd om een enkel molecuul genaamd dibenzoterrylene te detecteren in een nieuw kristal, en hebben ontdekt dat het een kandidaatbouwsteen is voor een kwantumnetwerk. Toekomstige kwantumcomputers hebben zo’n netwerk nodig om samen te werken zonder hun uitzonderlijke eigenschappen…
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Molecular electronics: Controlled manipulation, noise and graphene architecture
Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.
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Self-assembly of flexible and rigid structures: from colloidal molecules to lattices
Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…
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The Anharmonic Infrared Spectra of Polycyclic Aromatic Hydrocarbons
This thesis presents the anharmonic infrared spectra of a series of polycyclic aromatic hydrocarbons. Comparisons and characterizations are made based on high-resolution low-temperature gas-phase experimental spectra.
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Semi-empirical approach to the simulation of molecule-surface reaction dynamics
Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.
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Histone-DNA assemblies in archaea. Shaping the genome on the edge of life
All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).
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Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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Laboratory studies of Water Ice in Space
Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.
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Nanofluidic tools for bioanalysis : the large advantages of the nano-scale
Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)
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Linking simple molecules to grain evolution across planet-forming disks
Planets are formed in disks of gas and dust around young stars.
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Oratie: Het molecuul, de cellen en het weefsel: de wiskunde van groei en vorm in tijden van Big Data
Pas als we stap voor stap een plant of dier kunnen ‘bouwen’, begrijpen we hoe het organisme werkt. Zo kunnen we volgen en invoelen hoe eiwitten en DNA zich organiseren tot cellen en hoe cellen zich logischerwijs wel moeten organiseren tot weefsels, organen en hele dieren. Pas dan begrijpen we echt hoe…
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The environmentally-regulated interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
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From molecules to monitoring: Integrating genetic tools into freshwater quality assessments
Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.
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Structure dependence of molecular reactions on surfaces
The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.
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Orrit ontvangt OTP subsidie van NWO-TTW
Michel Orrit heeft een subsidie ontvangen uit het NWO-TTW Open Technologieprogramma. Hij gaat de kleine half miljoen euro gebruiken om individuele moleculen in beeld te brengen zonder fluorescentie te gebruiken.
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Mosselen organiseren zich als moleculen in materiaal
Mosselen in mosselbedden vormen een patroon dat lijkt op de organisatie van moleculen en atomen in materialen als brons, staal of rubber. Dit gedrag kan dan ook worden beschreven met hetzelfde wiskundige model.
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Synthetische moleculen leren om te communiceren
Pas sinds maart dit jaar werkt Sander Wezenberg in Leiden, maar hij heeft nu al een Vidi-beurs van NWO binnen weten te halen. Geïnspireerd door de natuur wil Wezenberg synthetische moleculen tot leven wekken en ze leren communiceren. Maar wie is Wezenberg precies en wat drijft hem?
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Isotopes and the characterization of extrasolar planets
Diverse types of exoplanets such as gas giants on close-in orbits (hot Jupiters) and young massive giants on wide orbits (super Jupiters), with no analogs in the Solar System, pose challenges but also opportunities to our understanding of planet formation and evolution.