413 zoekresultaten voor “design” in de Publieke website
-
Understanding deep meta-learning
The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.
-
Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
-
Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
-
Multi-dimensional feature and data mining
In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.
-
Synthesis of oligosaccharide libraries from GBS capsular polysaccharides for structure-based selection of vaccine candidates
Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.
-
Synthetic Study on ADP-ribosylation
This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.
-
Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
-
Roozbeh Siyadatzadeh
Wiskunde en Natuurwetenschappen
s.r.siyadatzadeh@liacs.leidenuniv.nl | +31 71 527 4799
-
Kernteam
Het kernteam van het PDC is verantwoordelijk voor onderzoek en ontwikkeling van de LMW-methode en voert het beheer van de LMW trajecten binnen de verschillende deelnemende instellingen.
-
Rosema & Louwerse, ‘Response scales in Voting Advice Applications’
Stemwijzers—applicaties die kiezers helpen te bepalen welke partij of kandidaat het beste past bij hun politieke voorkeur—spelen een steeds belangrijker rol in verkiezingen. De politicologen Martin Rosema (Universeit Twente) en Tom Louwerse (Universiteit Leiden) onderzoeken of het ontwerp van deze publicaties…
-
Platform for Arts Research in Collaboration (PARC) |>/~\|≥(
Het Platform for Arts Research in Collaboration (PARC) is een nieuw online en offline platform voor onderzoekers die werkzaam zijn op het gebied van compositie, muziek, kunst en design en daarbuiten, om kennis, ervaringen en openbare evenementen uit te wisselen, samenwerking te stimuleren en de zichtbaarheid…
-
RESOCIAL
RESOCIAL (“User vulnerabilities and Resilience on SOCIAL media platforms and the metaverse: a sociolegal and design perspective”) streeft ernaar menselijke kwetsbaarheden op sociale mediaplatforms te identificeren, te meten en daarmee te verminderen waardoor de veerkracht van hun gebruikers wordt be…
-
Chainet - European network on chain analysis for environmental decision support
Analytical tools for environmental design and management in a systems perspective. The combined use of analytical tools.
-
Understanding the Heterogeneity of Corporate Entrepreneurship Programs
In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…
-
Schouwburgstraat Community Garden
In the Schouwburgstraat, LUGO is currently redesigning the back-garden in order to increase biodiversity and make it a more beautiful space. Throughout October 2023 until March 2024, we will be making changes to the garden with our team of volunteers.
-
The Proliferation of Dissenting Opinions in International Law
Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).
-
Software development by abstract behavioural specification
The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.
-
Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
-
Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
-
Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
-
Tuesday Talks
De maandelijkse dosis onderzoeksinspiratie van Leiden Science, van onze medewerkers, voor onze medewerkers en alle andere nieuwsgierigen. Op dinsdag 3 september geeft Ionica Smeets, hoogleraar wetenschapscommunicatie, een interessante lezing!
-
Florian Schneider
Gamic Learning in East Asian Studies - Wat kunnen spellen ons vertellen over de manier waarop mensen leren?
-
Onderzoeksprojecten
Het onderzoek binnen COI@Leiden is geclusterd rond twee thema's: duurzame rechtspraak en de rechtszaal als maatschappelijke arena. Lees meer over elk van deze projecten door op de onderstaande links te klikken.
-
Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
-
The synthesis of mannose-derived bioconjugates and enzyme inhibitors
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee
-
Electrocatalytic reduction of CO2 and nitrate on immobilized metal porphyrins
M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid
-
NMR structural studies of protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal
-
Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
-
BioSustain
Examining the sustainability aspects of biotechnology, especially those related to the production of ethanol from biomass.
-
Machine Learning
Computers zijn in staat om ongelooflijk nauwkeurige voorspellingen te doen op basis van machine learning. Met andere woorden, deze computers kunnen zonder tussenkomst leren als ze eenmaal door mensen zijn voorgeprogrammeerd. Bij LIACS verkennen en verleggen we de grenzen van wat een revolutionaire nieuwe…
-
Verandering van geloofsvoorstelling: Analyse van legitimaties door Antony Flew, Cees Dekker en Raymond Bradley
Michiel Pronk verdedigde zijn proefschrift op 30 maart 2016
-
SHINE-VR: ScHaamte INtErventie
SHINE-VR is een korte interventie in Virtual Reality (VR) die wordt toegevoegd aan een reguliere traumabehandeling (TF-CBT). We onderzoeken de effectiviteit ervan met een experimenteel ontwerp waarbij naar individuele gevallen wordt gekeken. Dit doen we specifiek met jongvolwassenen die seksueel misbruik…
-
Advances in computational methods for Quantum Field Theory calculations
In this work we describe three methods to improve the performance of Quantum Field Theory calculations.
-
Non-Abelian metamaterials: emergent computing and memory
In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.
-
A multilateral tax treaty
Dirk Broekhuijsen is op donderdag 16 november 2017 gepromoveerd op zijn proefschrift ‘A multilateral tax treaty: designing an instrument to modernise international tax law’. Zijn promotoren zijn prof. mr. F.A. Engelen en prof. mr. S.C.W. Douma.
-
The synthesis of chemical tools for studying sphingolipid metabolism
Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.
-
Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
-
Pitch
De 5 beste businessplannen mogen een pitch verzorgen voor onze jury.
-
Interaction with sound for participatory systems and data sonification
This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.
-
Living Education Lab
This minor combines the domains of design thinking and technology-enhanced learning and teaching with interdisciplinary group work.
-
Clusters
De Una Europa Clusters brengen vooraanstaande deskundigen en ervaren personeelsleden van de talrijke academische en professionele diensten van de Una Europa -partners samen.
-
Studies into Interactive Didactic Approaches for Learning Software Design Using UML
Promotie
-
Rescue of Business in Insolvency Law
The ultimate aim of this project (initiated by the European Law Institute) is to design a framework that will enable the further development of coherent and functional rules for business rescue in Europe.
-
Research Assistant on Law and Human Vulnerability in Social Media 0,8 - 1,0 fte
Rechtsgeleerdheid, Instituut voor Metajuridica, eLaw - Centrum voor Recht en Digitale Technologie
-
Projectoverzicht
Weet jij hoe groot het heelal is? Reis in vijf workshops mee door de ruimte en ga met ons op zoek naar leven. In deze cursus ontmoet je échte sterrenkundigen en leer je hoe het is om sterrenkundig onderzoek te doen. Ontwerp, bouw en test je eigen alien, zodat deze de barre omstandigheden op andere planeten…
-
Impacts of the use of Natural Resources and Products
Development of an aggregated impact indicator to measure decoupling.
-
Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
-
Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
-
Algorithms for analyzing and mining real-world graphs
Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters
-
Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.