837 zoekresultaten voor “cancer drug discovery initiative” in de Publieke website
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Verblijfstijd geneesmiddel op doelmolecuul even belangrijk als ‘klik’
Niet alleen de ‘klik’ van een geneesmiddel met het doelmolecuul in het lichaam bepaalt de werking ervan, maar ook de tijd die het geneesmiddel op het molecuul doorbrengt. Leidse onderzoekers gaan met 15 miljoen euro een Europees consortium leiden om vanuit dit nieuwe concept betere medicijnen te mak…
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Plan B for particle physics: finding long lived particles at CERN
This thesis discusses the discovery potential of Intensity Frontier experiments.
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Tailored treatment for colon and rectal cancer
Promotie
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Genetic and lifestyle factors in breast cancer prognostication
Promotie
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Erik Danen wil tumoren vangen in hun eigen web
Erik Danen speurt met succes naar wegen om tumoren die slecht op medicijnen reageren de pas af te snijden. De hoogleraar Cancer Drug Target Discovery kijkt hiervoor naar de interactie tussen tumorcellen en hun omgeving. Oratie vrijdag 10 mei.
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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Causal Discovery: Challenges and Opportunities
Lezing
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Prediction of contralateral breast cancer - Statistical aspects and performance assessment
Promotie
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Spectroscopic characterization of exoplanets: From LOUPE to SINFONI
Over the past years it has been discovered that the population of extra-solar planets is large and diverse.
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Witnessing the Process of Bacterial Cell Death: Novel Antimicrobials and Their Mechanisms of Action
This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…
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Eregalerij 2022
In 2022 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.
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Esther Huiskers-Stoop en Diego Quiñones Cruz geven presentatie over Cooperative Compliance voor ontwikkelingslanden aan de OESO
De organisatie voor Economische Samenwerking en Ontwikkeling (OESO) heeft in samenwerking met het Inter-American Center of Tax Administrations (CIAT) op 27 november 2023 een wereldwijde online Tax Morale Workshop georganiseerd, waar Esther Huiskers-Stoop van de Universiteit Leiden en Diego Quiñones…
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Immuno-photodynamic therapy of cancer
Promotie
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Experimental optical imaging during pancreatic cancer interventions
Promotie
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Optimizing clinical management of T1 colorectal cancer
Promotie
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Harnessing neoantigens for targeted cancer treatment
Promotie
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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Mechanisms of Ewing sarcoma metastasis
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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Leukemia treatment & cognitive development
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Inhibitors and activity-based probes for β-D-glucuronidases, heparanases and β-L-arabinofuranosidases
Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
- Drugs & kunst/literatuur
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Sebastian Pomplun treedt toe tot Oncode Institute om doorbraken in het kankeronderzoek te versnellen
Met medicijnen eiwitten bereiken die onbereikbaar leken. Dat lukt Sebastian Pomplun. Daarom mag hij met zijn onderzoeksgroep toetreden tot Oncode Institute. Met negen anderen is hij uit 72 kandidaten geselecteerd om bij te dragen aan de missie van Oncode Institute: doorbraken in het kankeronderzoek…
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Unraveling mucin type o-glycosylation signatures of colorectal cancer
Promotie
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Characterization of candidate genes in unexplained polyposis and colorectal cancer
Promotie
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Improving Diagnostic, Prognostic and Predictive Biomarkers in Colorectal Cancer
Promotie
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The tumor-stroma ratio in epithelial cancer types
Promotie
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Early Detection of Pancreatic Cancer in High-Risk Individuals
Promotie
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Towards personalized treatment for high risk endometrial cancer
Promotie
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Quality assessment and multi modalty in gastric cancer treatment
Promotie
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Understanding the complexity of TGF-beta signaling in cancer
Promotie
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Refining individualized treatment in older patients with breast cancer
Promotie
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Diagnostic challenges of today's lung cancer pathology
Promotie
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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Nieuwe hoogleraar wil betere zorg door app voor sarcoompatiënten
Artsen moeten samen met patiënten met bot- en wekedelentumoren op zoek naar een optimale persoonlijke behandelstrategie, vindt prof. dr. Michiel van de Sande. Hij heeft een app ontwikkeld die bij de behandelkeuze ondersteunt. Van de Sande is vanaf 1 mei 2020 benoemd tot Leidse hoogleraar Orthopedie,…
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EuDEco case study report (D1.3)
D1.3 describes a set of five case studies relevant in the context of the EuDEco project. Case studies are considered relevant if they are initiatives focusing on the promotion of big data and data reuse or pilots facilitating data reuse in one form or the other. The case studies were expected to allow…
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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De impact van onze producten en diensten op het milieu en klimaat: hoe te meten?
De auto die we kopen is gemaakt van duizenden componenten, die weer gemaakt zijn van verschillende typen materialen. Deze materialen zijn op zichzelf weer afkomstig van verschillende plekken, worden naar productiefaciliteiten gestuurd en verzameld tot een product. Zodra de auto afgedankt is, moeten…
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Optimizing immunotherapy in locoregional and metastatic urothelial cancer
Promotie
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Composition and function of integrin adhesions
Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.
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NL-BioImaging AM
NL-BioImaging AM is een onderzoeksinfrastructuur gericht op het bevorderen van vooruitgang in de meest geavanceerde microscopietechnologieën en het bieden van open toegang tot deze technologieën aan een brede gemeenschap van academische en industriële gebruikers. Alle Nederlandse bio(medische) microscopie…