1,374 zoekresultaten voor “computer aided drug design” in de Publieke website
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Computational speedups and learning separations in quantum machine learning
This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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The role of glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Strategies for braiding and ground state preparation in digital quantum hardware
With the help of quantum mechanics, digital quantum hardware may be able to tackle some of the problems that are too difficult for ordinary computers. But despite these expectations and the ongoing effort of the research community, reliable quantum computers are not yet realized in a lab setting.
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Computer voorspelt reacties tussen moleculen en oppervlakken
Goed nieuws voor de heterogene katalyse en de waterstofeconomie: reacties van (waterstof)moleculen met oppervlakken kunnen nu met de computer accuraat worden voorspeld. Een internationaal team van onderzoekers, onder leiding van Leids theoretisch chemicus Geert-Jan Kroes, publiceert hierover in het…
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Abolfazl Sajadi
Wiskunde en Natuurwetenschappen
a.sajadi@liacs.leidenuniv.nl | +31 71 527 4799
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Peng Sun
Wiskunde en Natuurwetenschappen
p.sun@cml.leidenuniv.nl | +31 71 527 2727
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Alles wat we weten leesbaar maken voor computers
We moeten onze data en informatie opslaan op een manier die de computer begrijpt. Dat zegt Barend Mons, hoogleraar Biosemantiek bij het Leids Universitair Medisch Centrum en voorzitter van de High Level Expert Group for the European Open Science Cloud. We praten met hem over FAIR data, knowlets en n…
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Master Computer Science in Leiden nr.1 volgens Elsevier
Master Computer Science in Leiden nr.1 volgens Elsevier
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Simone van der Hof sprak over privacy by design en kinderrechten in Londen
Op 17 november 2017 gaf professor Simone van der Hof een duo-lezing met haar collega Professor Eva Lievens van de Universiteit Gent tijdens de ‘Children and Digital Rights’ conferentie aan het Information Law and Policy Centre, dat onderdeel is van het Institute of Advanced Legal Studies (University…
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Julia Cramer in Leidsch Dagblad over Quantum Computers
Tessa de Wekker van het Leidsch Dagblad interviewde Julia Cramer over quantum computers, quantuminformatie en de maatschappelijke impact die van de toepassingen.
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink
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Elsevier: Wiskunde en Computer Science in Leiden de beste
Zowel de Leidse bacheloropleiding Wiskunde als de masteropleiding Mathematics worden door hoogleraren als beste van Nederland beoordeeld, dit blijkt uit onderzoek van weekblad Elsevier. De Leidse masteropleiding Computer Science wordt door studenten beoordeeld als beste van Nederland.
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Computed fingertip touch for the instrumental control of musical sound with an excursion on the computed retinal afterimage
Promotor: Prof.dr. S. Haring
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PROGENY
How do you make a technology sustainable that does not even exist yet? Well, by bringing together an interdisciplinary team of pioneering European experts right at the start and paying attention to sustainability right from the development phase.
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Credible sets in nonparametric regression
Promotor: Prof.dr. A.W. van der Vaart
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The optimization and scale-up of the electrochemical reduction of CO₂ to formate
Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…
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Informatica
Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…
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Instituten
De Universiteit Leiden heeft onderzoeksinstituten gevestigd in Leiden en Den Haag.
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Contact
De Faculteit der Wiskunde en Natuurwetenschappen is gevestigd op verschillende locaties in het Bio Science Park Leiden.
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Serge Rombouts: 'AI leert van hersenscans en zoekt mee naar diagnose'
De welbekende MRI-beelden met oplichtende actieve hersendelen, zijn het resultaat van berekeningen. Volgens Serge Rombouts is dat nog geen echte kunstmatige intelligéntie. 'Dat is het pas als de computer iets adviseert of beslist.’ Precies wat Rombouts wil bereiken. Hij werkt onder andere samen met…
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Non-Abelian metamaterials: emergent computing and memory
In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.
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Adolescents' responses to online peer conflict: How self‐evaluation and ethnicity matter
Tijdens het spelen van online games kunnen conflicten ontstaan. Novin, Bos, Stevenson en Rieffe onderzochten in dit artikel welke factoren maken dat de ene jongere daarbij bozer reageert dan de andere. In hun realistisch nagemaakte spel begon de zogenaamde medespeler plotseling te mopperen dat de deelnemer…
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Pharmacology based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof
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Coiled-coil mediated liposomal fusion: Asymmetric behaving peptide fusogens
Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Postdoc on Causal Machine Learning for Spatio-temporal Datasets
Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Medical Delta café: translation models for drug discovery and development, 8 oktober 2013
Onze gemiddelde leeftijd gaat omhoog en de behoefte naar goede gezondheidszorg wordt steeds groter. Nieuwe medicijnen moeten op de markt komen maar kosten voor de ontwikkeling daarvan moeten omlaag. Tijdens het Medical Delta café op 8 oktober presenteren o.a. dr. Leo Price, dr. Jan de Sonneville en…
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Exploring Images With Deep Learning for Classification, Retrieval and Synthesis
In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Improved hard real-time scheduling and transformations for embedded Streaming Applications
This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.
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Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
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Computer Science op 51e plaats in QS World Universities Ranking 2011
Computer Science op 51e plaats in QS World Universities Ranking 2011
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Rebekah Tromblé
Students Practicing Citizen Journalism
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Semi-partitioned Scheduling and Task Migration in Dataflow Networks
Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov
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Jaap van den Herik vertelt op BNR Nieuwsradio over computers en intuïtie
In de toekomst kunnen computers hun beslissingen baseren op intuïtie. Dat stelde Jaap van den Herik, directeur van het Leiden Centre of Data Science, afgelopen vrijdag tijdens zijn afscheidsrede als hoogleraar aan Tilburg University. In een interview met BNR Nieuwsradio onderbouwt hij zijn stelling.
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Generalized Strictly Periodic Scheduling Analysis, Resource Optimization, and Implementation of Adaptive Streaming Applications
This thesis focuses on addressing four research problems in designing embedded streaming systems.
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Algorithms for analyzing and mining real-world graphs
Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters