260 zoekresultaten voor “exposure therapie” in de Publieke website
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Pesticides and health – challenges and opportunities for exposure assessment
The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…
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Swimming Bass under Pounding Bass: fish response to sound exposure
Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn
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Pathogenese en therapie van kanker
Bij kanker groeien lichaamscellen ongecontroleerd. Het gedetailleerd in kaart brengen van hoe dit precies gebeurt maakt het mogelijk om efficiënte therapieën te ontwikkelen. Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en de Universiteit Leiden werken samen aan het vermeerderen van…
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Chris Hoeboer
Faculteit der Sociale Wetenschappen
c.m.hoeboer@fsw.leidenuniv.nl | +31 71 527 2727
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Routine Outcome Monitoring and Feedback in Psychological Therapies
Kim de Jong, Jaime Delgadillo en Michael Barkham bieden waardevolle inzichten in hun boek 'Routine Outcome Monitoring and Feedback in Psychological Therapies' over hoe therapeuten en stagiaires feedback kunnen gebruiken om beslissingen over behandelingen te onderbouwen en uiteindelijk de resultaten…
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
Dit masterprogramma voorziet je van de nodige competenties om een sleutelrol te spelen in het opkomende gebied van transfusiegeneeskunde. Het huidige concept omvat zowel transfusie van bloedbestanddelen als hematopoëtische transplantaties, cel- en weefseltherapie en immunotherapie. Gebieden die geïntegreerd…
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webinar Transfusion Medicine and Cellular and Tissue Therapies
Studievoorlichting
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Rianne de Kleine
Faculteit der Sociale Wetenschappen
r.a.de.kleine@fsw.leidenuniv.nl | +31 71 527 5435
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
This joint Master with the Autonomous University of Barcelona will the equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. The programme includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy, and…
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Targets and Antisense Oligonucleotide Mediated Exon Skipping Based Therapies in Arthritis
Promotor: G.J.B. van Ommen
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Erica Bohnen
Faculteit der Sociale Wetenschappen
e.a.h.bohnen@fsw.leidenuniv.nl | +31 71 527 3381
- De ultieme vorm van ‘personalized medicine’. Hoe ontwikkel je een therapie die toepasbaar is voor slechts één patiënt?
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Exposure and health Assessment of Persistent Organic Pollutants (POPs) at e-waste recycling site among workers in the informal sector in Nigeria
Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…
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Reducing daily-stress: Breaking a habit
Stress komt veel voor in de huidige samenleving. Dit is zorgwekkend, aangezien onderzoek herhaaldelijk heeft aangetoond dat stress een negatieve invloed heeft op de lichamelijke gezondheid. Zo vergroot stress bijvoorbeeld de kans op hart- en vaatziekten.
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The noisy underwater world: the effect of sound on behaviour of captive zebrafish
Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn
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internationale samenwerking aan voor ontwikkeling geneesmiddelen geavanceerde therapie
Het Skåne University Hospital, de Universiteit van Lund en het Leids Universitair Medisch Centrum (LUMC) gaan samenwerken om onderzoek, onderwijs en ontwikkeling op het gebied van ATMP's (Advanced Therapy Medicinal Products) verder te ontwikkelen. Dat is afgesproken in een Memorandum of Understanding…
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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The power of biotic ligand models : site-specific impact of metals on aquatic communities
Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink
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Seeing voices: the role of multimodal cues in vocal learning
Humans and songbirds learn their vocalizations early in life by exposure to the vocalizations of adult conspecifics. Often, better learning outcomes are achieved with live, social, tutors than with audio-only exposure to vocalizations.
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Fate, accumulation and impact of metallic nanomaterials in the terrestrial environment
The rapidly increasing commercial application of metallic nanoparticles within products will inevitably enhance the amount of NPs being released into soil.
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Wat werkt bij het voorkomen van sociale angst?
Programma's die de symptomen van sociale angst bij kinderen willen verminderen, omvatten doorgaans meerdere onderdelen, zoals blootstelling en mentale herstructurering. Het is onbekend of afzonderlijke onderdelen positieve effecten opleveren bij kinderen of dat een combinatie van onderdelen nodig is…
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water
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North Sea noise in the Anthropocene: an impact study of human-made impulsive sounds on free-ranging cod
Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.
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KibA Testen App
Kinderen met een specifieke fobie zijn overmatig bang voor bepaalde voorwerpen, dieren of situaties. Specifieke fobieën komen regelmatig voor in de kindertijd en kunnen het leven thuis, op school en daarbuiten best moeilijk maken. Samen met een groot internationaal team hebben we het KibA-programma…
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Develop a methodology for assessing the effective dose of nanomaterials for environmental risk assessment purposes
How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Integrating cellular and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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Structural characterization of the cell envelope of Actinobacteria under changing environments
Bacteria have the ability to alter their morphology in order to adapt to changing environments.
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
- Met Soundscaping naar meer balans in stedelijke leefomgeving
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David Heyne
Faculteit der Sociale Wetenschappen
d.heyne@fsw.leidenuniv.nl | +31 71 527 2727
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Onderwijs
In het academisch jaar 2023-2024 biedt het interdisciplinaire onderzoeksprogramma Sociale Veerkracht en Veiligheid vier vakken aan voor studenten die beginnen met het derde jaar van hun bachelor. Deze vakken zijn te volgen binnen de ruimte voor keuzevakken. Je kunt de vakken afzonderlijk als keuzevak…
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GLOBOX
GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.
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Stromale cellen onderdrukken afstotingsverschijnselen
Een nieuwe therapie voor de ernstige Graft-versus-Host ziekte.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Hoe klinkt het Hofplein, nu en in de toekomst?
Hoe ervaren omwonenden en gebruikers het Rotterdamse Hofplein? De uitkomsten en aanbevelingen van het geluidsbelevingsonderzoek staan in het rapport
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Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
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Miranda van Eck op Kennislink over geneesmiddelen tegen verstopte aderen
Zonder cholesterol kunnen we niet leven, maar te veel is ook weer niet goed.
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Welkom bij LUBEC – Volwassenen
LUBEC is gespecialiseerd in de diagnostiek en behandeling van de psychische gevolgen van trauma’s en van lichamelijke klachten en aandoeningen.
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?
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Effects of pesticides on aquatic macrofauna in the field
Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver