1,353 zoekresultaten voor “modelling ” in de Publieke website
-
Zsuzsa Bakk
Faculteit der Sociale Wetenschappen
z.bakk@fsw.leidenuniv.nl | +31 71 527 8032
-
Roy de Kleijn
Faculteit der Sociale Wetenschappen
kleijnrde@fsw.leidenuniv.nl | +31 71 527 3915
-
Mariana Braz Pires
Wiskunde en Natuurwetenschappen
m.braz.pires@cml.leidenuniv.nl | +31 71 527 2727
-
Tales Yamamoto
Wiskunde en Natuurwetenschappen
t.m.yamamoto@cml.leidenuniv.nl | +31 71 527 2727
-
Xining Yang
Wiskunde en Natuurwetenschappen
x.yang@cml.leidenuniv.nl | +31 71 527 2727
-
Suiting Ding
Wiskunde en Natuurwetenschappen
s.t.ding@cml.leidenuniv.nl | +31 71 527 5615
-
MULTIPLY - MULTIscale SENTINEL land surface information retrieval Platform
Aim: To develop and enable application of a practical, flexible, user-friendly platform to provide the scientific community with a tool to generate land surface products and its associated uncertainties and exploit these for data-intensive science.
-
Global fitness maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
-
Interactions from lipid membrane deformations
Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.
-
Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
-
Anyonic, cosmic, and chaotic: three faces of Majorana fermions
In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…
-
Stochastic resetting and hierarchical synchronisation
Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.
-
Calculated Moves: Generating Air Combat Behaviour
By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.
-
Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
-
Actors at work
Promotor: F.S. de Boer Co-promotor: P. T. de Gouw
-
Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
-
Blowup in the complex Ginzburg-Landau equation
Promotor: Prof.dr. A. Doelman, Co-promotor: V. Rottschäfer
-
Improving vegetation representation in Multi-sensor Earth Observation Products through phenology and trait-based priors
What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?
-
Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
-
Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
-
Structural Health Monitoring Meets Data Mining
Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe
-
When data compression and statistics disagree: two frequentist challenges for the minimum description length principle
Promotor: P.D. Grünwald
-
Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
-
NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
-
The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
-
Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
-
Studying the Benefits of Using UML on Software Maintenance: an Evidence-Based Approach.
Including modelling as part of software development appears to have various benefits.
-
G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
-
Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
-
Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
-
Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
-
Into the Darkness: Forging a Stable Path Through the Gravitational Landscape
In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.
-
Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
-
Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
-
Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
-
Data-driven donation strategies: understanding and predicting blood donor deferral
The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.
-
Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
-
Random walks and the contact process
Promotores: W. Th. F. den Hollander, M.O. Heydenreich
-
Towards predictive cardiovascular safety: a systems pharmacology approach
Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski
-
Novel pharmacometric techniques to quantify the pharmacodynamics of analgesics
The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.
-
Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
-
Samenwerkend leren bij lerarenopeldingen
Het ontwikkelen, gebruiken en evalueren van groepsopdrachten in het hoger onderwijs.
-
Functions of leptin in tuberculosis and diabetes: multi-omics studies across species
In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.
-
GLOBOX
GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.
-
On transport properties of Majorana fermions in superconductors: free & interacting
Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.
-
Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
-
Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
-
Probing new physics in the laboratory and in space
The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.
-
Playing dice with the Universe
The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.
-
Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.