3,065 zoekresultaten voor “mathematical and statistical modelling” in de Publieke website
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Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.
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glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and physiology based
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Light Weighed: On the Statistics and Systematics of Weak Gravitational Lensing
In astronomy, the interpration of observations and measurements plays a crucial role: we rely purely and fundamentally on the information that reaches us as observers. And 80% of all matter in the universe is undetectable directly.
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Knowledge extraction in the quantum random-oracle model
The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.
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Development of Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic Species
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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A recipe for desert: analysis of an extended Klausmeier model
Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk
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Global Scenarios of Environmental Impacts with Structural Economic Models
To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.
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Distributions
Statistical distributions in LCA and converting between different representations of these distributions.
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Enriching official economic statistics using data-driven modelling techniques
Netherlands Statistics (CBS), Leiden University and the University of Amsterdam have started a collaboration in the form of a research project titled 'Enriching official economic statistics using data-driven modelling techniques'.
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Biomimetic models of [NiFe] hydrogenase for electrocatalytic hydrogen evolution
The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.
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Compiling and Refining Environmental and Economic Accounts (CREAA)
CREEA is a FP7 project on compiling and refining environmental and economic accounts. The project runs from April 2011 to March 2014.
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Dynamical Gibbs-non-Gibbs transitions: a study via coupling and large deviations
Promotores: F.H.J. Redig, W.T.F. den Hollander
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Basic methods and reasoning in Biostatistics
Discover "Basic methods and reasoning in Biostatistics" at LUMC. Master fundamental tools for data description and statistical inference! Read more here.
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Basic methods and reasoning in Biostatistics
Discover "Basic methods and reasoning in Biostatistics" at LUMC. Master fundamental tools for data description and statistical inference! Read more here.
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Modelling the dynamics of the innovation process: a data-driven agent-based approach
Promotor: Prof.dr. B.R. Katzy
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Ruben Huele
Wiskunde en Natuurwetenschappen
huele@cml.leidenuniv.nl | +31 71 527 FLEX
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Spectral signatures of breaking of ensemble equivalence
This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…
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Driemaal Nederlands eremetaal bij European Girls’ Mathematical Olympiad
Het Nederlandse team was bij de achtste European Girls' Mathematical Olympiad zeer succesvol. Drie van de vier teamleden gingen met een medaille naar huis. De Wiskunde Olympiade vond dit jaar plaats van 7 tot 13 april in de Oekraïense hoofdstad Kiev.
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The power of biotic ligand models : site-specific impact of metals on aquatic communities
Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink
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arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Professor Richard Gill bij TEDxFlanders "Statistical Errors in Court"
Richard Gill, hoogleraar Statistiek bij de Universiteit Leiden, heeft onlangs een voordracht gegeven “Statistical Errors in Court” tijdens een recent evenement van TEDx Vlaanderen. Hij spreekt over de zaak Lucia de Berk, een verpleegster die, op basis van met name statistisch materiaal, schuldig werd…
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Modelling the role of mycorrhizal associations in soil carbon cycling: insights from global analyses of mycorrhizal vegetation
In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.
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Nucleosome stacking in chromatin fibers probed with single-molecule force- and torque-spectroscopy
In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.
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reductions in the speed of sound of the inflaton in cosmological data, and other topics
Promotor: Prof.dr. A. Achucarro
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Bayesian learning: challenges, limitations and pragmatics
This dissertation is about Bayesian learning from data. How can humans and computers learn from data?
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Metastability for low-temperature Kawasaki dynamics with two types of particles
Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi
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The evolution and plasticity of life histories upon variation in nutrition: on aging focused integrative approach
Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)
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Galaxy formation and the structure of the Universe
Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)
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Advances in Survival Analysis and Optimal Scaling Methods
This thesis is based on five papers on several topics.
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Non-Abelian metamaterials: emergent computing and memory
In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.
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Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.
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Novel system-inspired model-based quantum machine learning algorithm for prediction and generation of High-Energy Physics data
De huidige en toekomstige quantumcomputers vormen dezelfde uitdaging als de laser in zijn begindagen. In theorie werd voorspeld dat de laser een bron van zeer speciaal, zeer krachtig licht zou zijn. Maar in die tijd waren er geen duidelijke toepassingen voor. Critici van het idee noemden het een probleem…
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)
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Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Learning-based Representations of High-dimensional CAE Models for Automotive Design Optimization
In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…
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Impact assessment modelling of matter-less stressors in the context of Life Cycle Assessment
Promotoren: Prof.dr. G.R. de Snoo en Dr. R. Heijungs
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A New Model of Global Governance in International Tax Law Making (GLOBTAXGOV)
Dr. Irma Mosquera Valderrama onderzoekt in haar ERC-project de rol van de OESO (Organisatie voor Economische Samenwerking en Ontwikkeling) en de EU bij de totstandkoming van internationale fiscale wetgeving en streeft ernaar voorwaarden te scheppen waaronder zowel ontwikkelde landen als ontwikkelingslanden…
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Beyond the Born-Oppenheimer Static Surface Model for Molecule- Surface Reactions
Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.
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studies of angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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Fertility and fontanels: women’s knowledge of medicinal plants for reproductive health and childcare in western Africa
Promotor: E.F. Smets, Co-promotor: T.R. van Andel
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Evolution and development of orchid flowers and fruits
To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.
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The Chara plasma membrane system : an ancestral model for plasma membrane transport in plant cells
Multicellular giant algae Chara species have been widely used in physiological studies for decades.
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Het gebruik van een praktisch didactisch model door beginnend docenten voor het leren ontwerpen van lessen
Beginnend docenten hebben vaak moeite met het maken van activerende lessen. In dit onderzoek wordt gekeken hoe het didactisch bouwstenen model hen een helpende hand kan bieden bij het leren ontwerpen van lessen.