6,083 zoekresultaten voor “leiden institute for brain and cognition” in de Publieke website
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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800 mensen kijken in de wereld van het sociale brein
‘Of we nog een beetje kunnen aanschuiven, dan passen we er allemaal in.’ Uit het hele land komen mensen voor een interactieve dag over het sociale brein. Zes breinwetenschappers weten wat er leeft, blijkt op 6 november j.l. tijdens het publiekssymposium van het Leiden Institute for Brain and Cognition…
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Center for Interdisciplinary Placebo Studies Leiden
Het Center for Interdisciplinary Placebo Studies Leiden (IPS) streeft naar een beter begrip van placebo- en nocebo-effecten, hun onderliggende mechanismen en hun mogelijke toepassingen in de klinische praktijk. IPS bestaat uit een groep interdisciplinaire onderzoekers die werken aan de Universiteit…
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Stable single molecules for quantum optics and all-optical switches
Promotor: Prof.dr. M.A.G.J. Orrit
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Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?
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Artificial metallo-proteins for photocatalytic water splitting: stability and activity in artificial photosynthesis
Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.
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Environmental assessment and guidance for the future offshore wind energy development
This thesis aims to address offshore wind energy (OWE)-related environmental impacts.
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken
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Ruthenium- and cobalt-based artificial metalloenzymes for photocatalytic water oxidation in artificial photosynthesis
Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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(mixed CO/CO2 streams) into intermediates for polyurethane plastics for rigid foams/building insulation and coatings
What would be the environmental performance of the Carbon4PUR technology at industrial scale in the future?
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Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society
Op 23 oktober 2019 verdedigde Yoram Stein zijn proefschrift 'Spinoza's Theory of Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society'. Het promotieonderzoek is begeleid door promotor prof.dr. P.B. Cliteur en prof.dr. A.A.M. Kinneging.
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Bayesian Inference for Gaussian Models
This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.
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Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice
Miriam Cohen verdedigde haar proefschrift genaamd “Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice” op 28 juni 2017. Ze schreef haar proefschrift onder supervisie van prof.dr. L.J. van den Herik en prof. dr. C. Stahn.
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Quantifying material and carbon reduction in circular consumption: solving selected methodological and data challenges while accounting for rebound effects
To conclude, this thesis provides valuable methodological insights to address data gaps and improve environmental impact assessments within the circular economy, with a particular focus on product reuse and sharing practices. Through empirical analysis and innovative approaches, it aims to support informed…
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Digital tools for sign language research: towards recognition and comparison of lexical signs
Op 9 april promoveert Manolis Fragkiadakis. Het Leiden University Centre for Linguistics feliciteert Manolis!
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
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Material flow analysis for the C&D waste management systems in the Netherlands, Belgium, Spain and Finland
What are the flows of C&DW (e.g. bricks, concrete, gypsum and wood) in the case study countries ? How to define the specification for each material to be quantified? What indicators should be used to identify the pattern of each C&DW management system? How to interpret the MFA results in relation…
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Immunotherapy for metastatic melanoma and beyond
Promotie
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A monodromy criterion for existence of Neron models and a result on semi-factoriality
In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.
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Multi-Objective Bayesian Global Optimization for Continuous Problems and Applications
A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.
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When data compression and statistics disagree: two frequentist challenges for the minimum description length principle
Promotor: P.D. Grünwald
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Universal adelic groups for imaginary quadratic number fields and elliptic curves
Promotor: Prof.dr. P. Stevenhagen, Prof.dr. K. Belabas (Univ. de Bordeaux)
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Bernhard Hommel lid Nationale Akademie der Wissenschaften
Cognitief psycholoog prof.dr. Bernhard Hommel is gekozen tot lid van de Leopoldina, de Deutsche Akademie der Wissenschaften. Het lidmaatschap van de Leopoldina is een blijk van internationale erkenning.
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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Are we there yet? Advances in anytime-valid methods for hypothesis testing and prediction
Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…
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Academy of Creative and Performing Arts
De Academy of Creative and Performing Arts is een samenwerkingsverband tussen de Leidse universiteit en de Hogeschool der Kunsten Den Haag'. (Deeltijd)studenten van de Leidse universiteit kunnen hier theoretisch en praktisch kunstvakonderwijs volgen, waarvan de studiepunten meetellen voor hun bachelor-…
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
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Onderwijs
Het LIBC is actief betrokken bij training & onderwijs op het gebied van hersenen en cognitie.
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Brein op tournee in de Brain Awareness Week
‘Daar kunnen we wel wat mee’, dachten de Leidse psychologen Eveline Crone en Bart Vogelaar bij de ingestuurde vragen door de Haanstraschool. Daarmee verdiende de basisschool een lezing over hersenen, executieve functies en intelligentie op 14 maart in de Brain Awareness Week.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Bottlenecks and opportunities for improvement in cybercrime handling: Insights from Dutch police practice
De auteurs onderzoeken de afhandeling van cybermisdaadzaken door rechtshandhavers.
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Teachers' use of progress data in planning and evaluating instruction for students with learning disabilities
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Puberbrein sneller gealarmeerd na langdurig buitensluiten
Bij pubers die jarenlang zijn buitengesloten door klasgenoten wordt een alarmsysteem in de hersenen sterker geactiveerd op het moment dat ze opnieuw worden buitengesloten. Deze jongeren zijn waarschijnlijk extra gevoelig voor nare sociale ervaringen zoals uitsluiting. Promotie Geert-Jan Will op 4 ju…
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Measuring sustainability: an elaboration and application of the system of environmental-economic accounting for Indonesia
Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…
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Shaping multilateralism: Principles and opportunities for multilateral cooperation in the UN
Hoe kan internationale samenwerking worden bevorderd, nu de steun voor de mulilaterale aanpak van problemen afkalft? Gisela Hirschmann (Universiteit Leiden) en Cornelia Ulbert (Universiteit van Duisburg-Essen) doen enkele aanbevelingen.
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Delegation to Treaty Bodies and International Organisations for Conventional Arms Control Agreements in Europe
In dit artikel onderzoekt William Lippert hoe het overdragen van taken aan een uitvoerder van een overeenkomst van conventionele wapenbeheersing in Europa van invloed is op het succes ervan.
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Focal-plane wavefront sensors for direct exoplanet imaging: Theory, simulations and on-sky demonstrations
One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Improved hard real-time scheduling and transformations for embedded Streaming Applications
This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.
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Construction and exploration of modular goldnanoparticles for glycan-based immune-interventions of worm infections
Chiodo
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Parenthood, gender, and turning points to crime for young people in Latin America
Di Marco onderzoekt hoe ouderschap een cruciaal keerpunt vormt in het leven van jonge mensen in Latijns-Amerika, en van invloed is op hun criminele verleden.
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How Boys Deflect Responsibility for Street Harassment: Class, Race, and Responses to Sexual Violence Awareness Programs
Onderzoek toont aan hoe jongens reageren op bewustwordingstrainingen over intimidatie en waarom ze straatintimidatie vaak niet als 'hun' probleem zien.
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From Crisis to Inquiry: A Framework for Designing and Assessing Crisis Inquiries from a Learning Perspective
In dit artikel onderzoeken Wout Broekema, Wouter Jong en Sara Perlstein het ontwerp en de beoordeling van crisisonderzoeken vanuit een leerperspectief.
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Aanknopingspunt voor medicijnontwikkeling bij ziekte van Alzheimer
Psycholoog Bernadet Klaassens heeft een groot fMRI-onderzoek opgezet naar het effect van medicijnen op hersennetwerken bij veroudering en de ziekte van Alzheimer. Het leverde een unieke dataset op en zicht op een nieuwe methode om medicijnen te ontwikkelen voor patiënten met Alzheimer. Promotie op 6…
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Design and evaluation of video portfolios: reliability, generalizability, and validity of an authentic performance assessment for teachers
In welke mate zijn beoordelingen op basis van een videodossier betrouwbaar, generaliseerbaar en valide?