573 zoekresultaten voor “haar throughout screening and microscopy” in de Publieke website
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Microscopy Unit
De Microscopy Unit huisvest, onderhoudt en coördineert vrijwel alle microscopieapparatuur van het IBL. De beschikbare apparatuur varieert van conventionele licht- en fluorescentiemicroscopen tot confocale laser- en elektronenmicroscopen. Er is bovendien apparatuur beschikbaar voor histologie, met inbegrip…
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Single-molecule microscopy in zebrafish embryos
Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.
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Magnetic Resonance Force Microscopy and the Spin Bath
There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.
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eV-TEM: Transmission Electron Microscopy with few-eV Electrons
Electron microscopy has become an extremely important techniquein a wide variety of elds.
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Insights from scanning tunneling microscopy experiments into correlated electron systems
This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.
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Probing quantum materials with novel scanning tunneling microscopy techniques
This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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Light and Electron Microscopy Facility
Het doel van deze faciliteit is om het biomedisch onderzoek te versnellen door toegang te bieden tot geavanceerde licht- en elektronenmicroscopie en door het delen van expertise over monstervoorbereiding, beeldvormingsmodaliteiten, gegevensopslag en beeldanalyse.
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Low-Energy Electron Microscopy on Two-Dimensional Systems: Growth, Potentiometry and Band Structure Mapping
Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp
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Advances in SQUID-detected Magnetic Resonance Force Microscopy
In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).
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Two-photon multifocal microscopy for in vivo single-molecule and single-particle imaging
In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.
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Magnetic resonance force microscopy for condensed matter
In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.
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Josephson and noise scanning tunneling microscopy on conventional, unconventional and disordered superconductors
In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…
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Transmission electron microscopy on live catalysts
The dissertation describes TEM experiments on heterogeneous catalysts.
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mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Nuclear magnetic resonance force microscopy at millikelvin temperatures
Promotor: T.H. Oosterkamp
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Lasers, lenses and light curves: adaptive optics microscopy and peculiar transiting exoplanets
Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen
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Superlattices in van der Waals materials: A Low-Energy Electron Microscopy study
n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.
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Vertebrate automated screening technology (VAST)
Hoe kun je met robots en automatische herkenning van microscopische beelden uitzonderlijk snel het effect van medicijnen testen?
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
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Development of automatic image analysis methods for high-throughput and high-content screening
Promotor: Prof.dr. B. van de Water
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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Triblock polypept(o)ides for siRNA delivery: unique polymeric designs for versatile carrier systems
Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…
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Imaging complex model catalysts in action
From surface science towards industrial practice using high-pressure scanning tunneling microscopy.
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Probing molecular layers with low-energy electrons
Molecular materials have been a subject of interest in fundamental research and applications for decades, and have been studied as bulk crystals, (thin) films and as individual molecules, due to the large variety in their properties. This dissertation explores pentacene crystals near the two-dimensional…
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Biological model representation and analysis
Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek
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Visualizing strongly-correlated electrons with a novel scanning tunneling microscope
Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.
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Structural characterization of the cell envelope of Actinobacteria under changing environments
Bacteria have the ability to alter their morphology in order to adapt to changing environments.
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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Phase separation in lipid-based nanoparticles: exploring the nano-bio interface
This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.
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Nano-scale electronic structure of strongly correlated electron systems
In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.
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Reconstruction Methods for Combined HAADF-STEM and EDS Tomography
The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.
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The structure of a working catalyst: from flat surfaces to nanoparticles
Promotor: Prof.dr. J.W.M. Frenken
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Cryo Electron Tomography Studies On Bacterial Chemosensory Arrays
Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.
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Wim van Anrooij
Faculteit der Geesteswetenschappen
w.van.anrooij@hum.leidenuniv.nl | +31 71 527 2121
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Meiru Wang
Wiskunde en Natuurwetenschappen
m.wang@cml.leidenuniv.nl | +31 71 527 2727
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Musems, Collections and Society | Yearbook 2020
In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.