1,366 zoekresultaten voor “development disease” in de Publieke website
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Emotions and the psychosocial development of children with and without Developmental Language Disorder
Emoties en de psychosociale ontwikkeling van kinderen met en zonder Taal Ontwikkelingsstoornis
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper
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Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement
Op 26 juni 2019 verdedigde Lisa Louwerse haar proefschrift 'The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement'. Het promotieonderzoek is begeleid door promotor prof. mr. C.A.P. Hillion.
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Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.
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Microvasculature in Microfluidics: matching complexity with compatibility
In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…
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Regulation of the arabidopsis AGC kinase PINOID by PDK1 and the microtubule cytoskeleton
Plants, are sessile organisms, have developed strategies to adapt to changes in their environment, in part by altering their growth and development.
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Prestigieuze Edinburgh Medal voor 'Astronomy for Development'
De Edinburgh Medal 2016 is uitgereikt aan zowel Kevin Govender van de Office of Astronomy for Development (OAD) als de International Astronomical Union (IAU). De prijs is een erkenning voor het wereldwijd bevorderen van onderwijs en technologie door middel van sterrenkunde. Het programma is het geesteskind…
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induction programs on beginning teachers'well-being and professional development
Dit proefschrift gaat over de invloed van inductieprogramma’s op het welbevinden en de professionele ontwikkeling van beginnende docenten, en welke specifieke kenmerken van inductieprogramma’s daarvoor belangrijk zijn. Hiernaar is onderzoek gedaan met een interviewstudie en een grootschalige vragenl…
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Knowledge development of secondary school L1 teachers on concept-context rich education in an action-research setting
In deze studie wordt verslag gedaan van een onderzoek naar de ontwikkeling van de praktijkkennis bij elf docenten Nederlands. Zij ontwikkelden en implementeerden concept-contextrijk onderwijs met behulp van actieonderzoek.
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
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Java: the role of indigenous institutions in integrated elderly care development in Indonesia
This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…
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Pesticides and health – challenges and opportunities for exposure assessment
The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…
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Transfer of "goods" from plants to humans: Fundamental and applied biochemical investigations on retaining glycosidases
The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.
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Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot
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Onderzoekers gaan de strijd aan met antibioticaresistente bacteriën
Wanneer een bacterie resistenter wordt voor het ene antibioticum, wordt het soms gevoeliger voor een ander. Om deze wisselwerking beter te begrijpen, brachten onderzoekers van het Instituut Biologie Leiden (IBL) en het Leiden Academic Centre for Drug Research (LACDR) onder leiding van Daniel Rozen en…
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Annemarie Meijer wordt trainingscoördinator in Europees netwerk
Het nieuwe project INFLANET gaat jonge wetenschappers in Europa opleiden tot experts in onderzoek naar ontstekingen. Professor Annemarie Meijer van het Instituut Biologie Leiden coördineert de training.
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Data-Driven Machine Learning and Optimization Pipelines for Real- World Applications
Machine Learning is becoming a more and more substantial technology for industry.
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Algorithm for Structural Variant Detection
Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.
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Microscopy Specialist
Wiskunde en Natuurwetenschappen, Instituut Biologie Leiden (IBL)
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Forces and symmetries in cells and tissues
The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.
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‘Ik heb altijd gewerkt aan een betere wereld. Hier bij Biologie doen we dat ook’
De nieuwe instituutsmanager van het IBL studeerde zelf een half jaar biologie, maar ging toch een heel andere kant op: ontwikkelingssamenwerking en de financiële sector. Drie decennia later maakt Resi Janssen een radicale carrièreswitch. Of toch niet? ‘Ik wil dat we over tien jaar in een nieuw, duurzaam…
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Modern Drug Discovery
How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…
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Comorbidities, complications and treatment of childhood obesity
Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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LLP-studenten aan de slag bij Janssen voor een World Without Disease
Een wereld zonder ziekte: toekomst of illusie? In ieder geval het nastreven waard, vinden ze bij Janssen, dat de mogelijkheden voor zo’n wereld daarom onderzoekt. Studenten van het Leiden Leadership Programme brachten voor het bedrijf enkele dilemma’s in kaart die daarbij een rol kunnen spelen.
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‘Defense, diplomacy, development… and disillusions’
De opzet van de Britse en Nederlandse missies in Zuid-Afghanistan werd ingegeven door Westerse vooringenomenheid, in plaats van door een gedegen, open analyse. Tot deze slotsom komt politicologe en majoor Mirjam Grandia in haar promotieonderzoek naar de Britse en Nederlandse besluitvorming rond de missies…
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Studying the Benefits of Using UML on Software Maintenance: an Evidence-Based Approach.
Including modelling as part of software development appears to have various benefits.
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Developmental effects of polystyrene nanoparticles in the chicken embryo
There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
Hoe kan de methode om de gecombineerde effecten van metaal-gebaseerde chemische stoffetn te bepalen worden verbeterd?
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Plural Medical System in Pirgos and Praitoria for Community Health Development in Rural Crete, Greece
Promotor: Prof.dr. L.J. Slikkerveer
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Quantitative pharmacological modelling for optimizing treatment of sepsis
Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.