626 zoekresultaten voor “cancer drug resistance” in de Publieke website
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Photodynamic therapy-based combinations with immunotherapy in colon cancer treatment
Promotie
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
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Personalized drug repositioning using gene expression
Promotie
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Inducing spin triplet superconductivity in a ferromagnet
Promotor: J. Aarts
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Flow: A study of electron transport through networks of interconnected nanoparticles
This thesis describes a study from both a theoreticaL and an experimental point of view.
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Chemical biology of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Imaging complex model catalysts in action
From surface science towards industrial practice using high-pressure scanning tunneling microscopy.
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More JAZ in the orchestration of jasmonate-mediated plant defense
Prof.dr. J. Memelink
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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Onderzoekers gaan de strijd aan met antibioticaresistente bacteriën
Wanneer een bacterie resistenter wordt voor het ene antibioticum, wordt het soms gevoeliger voor een ander. Om deze wisselwerking beter te begrijpen, brachten onderzoekers van het Instituut Biologie Leiden (IBL) en het Leiden Academic Centre for Drug Research (LACDR) onder leiding van Daniel Rozen en…
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Enorme databases doorlichten op zoek naar een medicijn tegen kanker
Bij onderzoek naar geneesmiddelen zou meer gebruik moeten worden gemaakt van data science. Dat zegt Gerard van Westen, postdoctoraal onderzoeker bij het Leiden Academic Centre for Drug Research (LACDR). ‘Als je betere medicijnen wilt hebben, moet je starten bij data.’
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Promotie
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Knowledge discovery from patient forums: gaining novel medical insights from patient experiences
Patients share valuable advice and experiences with their peers in online patient discussion groups.
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Lioe-Fee de Geus-Oei
Faculteit Geneeskunde
l.f.de_geus-oei@lumc.nl | +31 71 526 9111
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Pancreatic cancer: Chasing the light at the end of the tunnel
Promotie
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Untangling the immune landscape of colorectal cancer by in situ multiplex immunophenotyping
Promotie
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Partial Breast Irradiation in elderly patients with early-stage breast cancer
Promotie
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Immunosuppression in breast cancer: a closer look at regulatory T cells
Promotie
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Systems biology as a compass to understand cancer-immune interactions in humans
Promotie
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The impact of one: single cell analysis of T cell states in human cancer
Promotie
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The role of the Bone Morphogenetic Protein Pathway in Colorectal Cancer
Promotie
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TGF-β signaling dynamics in epithelial-mesenchymal plasticity of cancer cells
Promotie
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Huidonderzoeker pleit voor multidisciplinaire samenwerking: ‘Ik wil expertise bundelen.'
In de dermatologie zou op grote schaal multidisciplinair moeten worden samengewerkt tussen instituten en specialisten, stelt Robert Rissmann, hoogleraar Translationele Dermatologie, in zijn oratie van 8 juli. Hij bouwt een infrastructuur om pre-klinisch en klinisch huidonderzoek prominent op de kaart…
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pharmacogenetics of systemic and intraperitoneal chemotherapy in colorectal cancer
Promotie
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Light therapy for cancer-related fatigue in (non-)Hodgkin Lymphoma Survivors
Promotie
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Supporting women with breast cancer in making an informed decision about immediate breast reconstruction
Promotie
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Sexual Health Care in Prostate Cancer for Men and their Partners
Promotie
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Colorectal cancer screening for average- and high-risk individuals Beyond one-size-fits-all
Promotie
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Computational modeling of pharmacokinetics and tumor dynamics to guide anti-cancer treatment
Promotie
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Molecular imaging of pancreatic and rectal cancer - Towards optimized detection and response prediction
Promotie
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Text-mining real-world data to evaluate systemic anti-cancer therapy
Promotie
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Dubbelslag tegen ontstekingsziekten
Combinatie van twee potentiële geneesmiddelen geeft zicht op een 'superblokkade' van een overactief immuunsysteem, schrijven Leidse wetenschappers in Nature. De doorbraak was het kristalliseren van het betrokken membraaneiwit.
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Zebrafish embryos and larvae as a complementary model for behavioural research
Promotor: Prof.dr. M.K. Richardson
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Systems pharmacology of the amyloid cascade
According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Faith in Democracy. Justice, Politics and Transcendence
This book explores the spiritual potential of faith, mysticism and transcendence in answer to the dangers of a mythologised state and the sacro-sanctification of (liberal) democracy and its rule of law.
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Designing Ships using Constrained Multi-Objective Efficient Global Optimization
A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Wiskunde en Natuurwetenschappen
Binnen de Faculteit der Wiskunde en Natuurwetenschappen zijn 8 instituten:
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.
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for the evaluation of experimental therapy in prostate and bladder cancer
Promotie