1,211 zoekresultaten voor “more disorder” in de Publieke website
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Nonverbal Learning Disorder (NLD)
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Disorder and interactions in high-temperature superconductors
This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.
- From basic research to therapy development for neuromuscular disorders
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psychosocial development of children with and without Developmental Language Disorder
Emoties en de psychosociale ontwikkeling van kinderen met en zonder Taal Ontwikkelingsstoornis
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More Is Alive: Emergent Multi-Scale Order & Collective Flows In Tissues
Promotie
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Early clinical and imaging features of rheumatoid arthritis: Towards a more complete picture
Promotie
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More JAZ in the orchestration of jasmonate-mediated plant defense
Prof.dr. J. Memelink
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Who is Afraid of More Women in Politics, and Why? An Analysis of Public Opinion in 28 European Countries
In dit artikel bestuderen de auteurs hoe individuele variabelen en variabelen op landelijk niveau op elkaar inwerken bij het beïnvloeden van politieke genderattitudes in Europa.
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Nieuwe inzichten in eigenschappen van Conduct Disorder met “beperkte prosociale emoties”
In een recente studie tonen dr. Moji Aghajani en collega’s aan dat jongeren met een ernstige vorm van Conduct Disorder (CD) -met beperkte prosociale emoties- opvallend veel hersencapaciteit nodig hebben om emotionele gezichten te kunnen lezen. Deze effecten werden gevonden in vergelijking met CD-jongeren…
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
Hoe kan de techniek van cell wall engineering worden ingezet zodat de industrie streptomyceten beter kunnen verwerken tot nieuwe antibiotica?
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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On electronic signatures of topological superconductivity
Promotor: Prof.dr. C.W.J. Beenakker
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Bioclock: Lichttherapie voor depressie
Optimalisatie, werkingsmechanismen en voorspellers van het resultaat van lichttherapie bij depressie: Een multicenter gerandomiseerde trial
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PhD position: ultrafast broadband-THz spectroscopy of perovskite materials
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
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Onderzoek
The aim of our research program is to better understand the aetiology and course of mood, anxiety and trauma and stressor-related disorders and to test and improve treatments for these disorders.
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Lipidomics study in liver metabolic diseases
The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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ENIGMA-Anxiety Werkgroep
Samen met wetenschappers van over de hele wereld streeft de ENIGMA-Anxiety Werkgroep ernaar om meer inzicht te krijgen in de neurobiologische karakteristieken van angststoornissen.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Wetenschappelijke publicaties
Een lijst met wetenschappelijke publicaties samengesteld door het team van het TRIXY Expertisecentrum.
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Empathic or anxious mistakes?
A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Exposed to events that never happen: Genaralized unsafety and prolonged psysiological stress responses
The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.
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Binge- eating disorder in the Arabic world and the Netherlands
Promotie
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Predictors, symptom dynamics and neural mechanisms of bipolar disorders
Promotie
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Bone and joint disorders: Screening and early clinical drug development
Promotie
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Immune modulation and monitoring of cell therapy in inflammatory disorders
Promotie
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Extremely shy and genetically close
Investigating neurobiological endophenotypes of Social Anxiety Disorder
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Podcast: Een leven met Bipolaire Stoornis
We praten met Justin, die ruim 14 jaar geleden gediagnostiseerd werd met Bipolaire Stoornis type 1. Justin is erg openhartig en vertelt over zijn eerste manische episode op 28 jarige leeftijd, en hoe hij heeft geleerd om een stabiel leven te kunnen leiden. Met Justin gaat het goed, en dat heeft hij…
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Marike Kooistra
Faculteit der Sociale Wetenschappen
m.j.kooistra@fsw.leidenuniv.nl | +31 71 527 1726
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Seksuele responsen zijn aan én af te leren
Ongewenste associaties met seks kunnen afgeleerd worden, maar terugkeren als de omstandigheden veranderen. Daarom moet het afleren in diverse situaties plaatsvinden. Het geneesmiddel D-cycloserine biedt mogelijk uitkomst. Dat ontdekte psychologe Mirte Brom.
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Achtergrondinformatie
Cool Little Kids is een onderzoeksproject ter preventie van angstproblemen bij verlegen en teruggetrokken kinderen van 3-6 jaar die extreem verlegen of angstig zijn.
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Multimodal Data and Machine Learning in the Study of Psychiatric Disorders
Promotie
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Internet-Based Treatment for Eating Disorders: Bridging the Treatment Gap
Promotie
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Perspectives on shared decision-making for depression and anxiety disorders in clinical practice
Promotie
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Metabolomics assisted with stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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Flow: A study of electron transport through networks of interconnected nanoparticles
This thesis describes a study from both a theoreticaL and an experimental point of view.
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Shy parent, shy child?
Delineating psychophysiological endophenotypes of social anxiety disorder
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Beter begrip van emoties bij Borderline Persoonlijkheidsstoornis
Psycholoog Anne Krause heeft de hersenen onderzocht van mensen met Borderline Persoonlijkheidsstoornis bij wie vaak dissociatie voorkomt in combinatie met stress. Daarbij blijkt de activiteit in een bepaald hersengebied verlaagd. Dit zou de oorzaak kunnen zijn van hun veranderde emoties tijdens dissociatie.…