The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Het Computer Systems, Imagery & Media (CSI) onderzoeksprogramma voert fundamenteel onderzoek uit naar methoden en technieken voor het ontwerp, de implementatie en de applicatie van geavanceerde computersystemen.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Het onderzoek van dit programma is gecentreerd rond dynamische systemen, functionele analyse en hun interactie.

Promotor: Arjen Doelman, Co-promotor: Vivi Rottschäfer

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

Van systeembiologische modellering een centrale pijler van het onderzoek in de biologie maken.

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Deze opleiding is gericht op de ontwikkeling van computermodellen die de werking van medicijnen voorspellen, het individualiseren van bestaande behandeltherapieën en het ontwikkelen van innovatieve, analytische tools voor het personaliseren van de gezondheidszorg.

Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: S.M. Verduyn Lunel, Co-promotoren: M.F.E. de Jeu, S.D. Silvestrov

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Promotor: Prof.dr. S.F. Portegies Zwart

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Promotor: S.M. Verduyn Lunel

O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.

Op 29 januari 2019 verdedigde Robbert van Eijk proefschrift 'Web Privacy Measurement in Real-Time Bidding Systems, A Graph- Based Approach to RTB system classification'. Het promotieonderzoek is begeleid door promotor prof. dr. H.J. van den Herik.

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

Promotores: W. Jiskoot, F. Ossendorp

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.