756 zoekresultaten voor “cancer drug discovery initiative” in de Publieke website
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Small-molecule inhibitors of bacterial metallo-β-lactamases
The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Regulation of TGF-β signaling and EMT in cancer progression
Promotie
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Judith Bovée
Faculteit Geneeskunde
j.v.m.g.bovee@lumc.nl | +31 71 526 9111
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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Rare Earth Supply Chain and Industrial Ecosystem: A Material Flow Assessment of European Union
1) Assess the trends in supply and production status of these critical minerals and mineral products worldwide and Europe’s dependence including on intermediate products such as permanent magnets, RE based super alloys, batteries, polishing compounds, phosphors, catalysts etc. 2) Trace the entire value…
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Constraints on large-scale implementation of BioSolarCells, Early stage assessment of environmental value propositions
What performance criteria does a new technology have to fulfill in order to be added to the list of future energy options and what constraints exist in terms of broad market penetration?
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EU JudgeCo Platform
The ultimate aim of this project is to improve cooperation between courts in different Member States.
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Antoni van Leeuwenhoek en LUMC slaan handen ineen voor immuuntherapie
Het eigen afweersysteem van een kankerpatiënt versterken zodat het lichaam zelf beter kankercellen kan vernietigen. Het is de kern van immuuntherapie, de hoopgevendste vooruitgang binnen de behandeling van kanker van de afgelopen jaren. Om deze ontwikkeling verder aan te jagen slaan het Antoni van Leeuwenhoek/Nederlands…
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Therapeutisch vaccin vergroot overlevingskans voor patiënten met baarmoederhalskanker
Patiënten met baarmoederhalskanker hebben een grotere overlevingskans door een therapeutisch HPV-16 vaccin. Een nieuwe studie van het Leidse biotechnologie bedrijf ISA Pharmaceuticals B.V. en het Leids Universitair Medisch Centrum (LUMC) bewijst dat de response van het vaccin versterkt kan worden in…
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barriers: unraveling response mechanisms to immunotherapy in breast cancer
Promotie
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Tumor-specific targets for imaging in vulvar cancer
Promotie
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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Pieter Tops in Binnenlands Bestuur en Platform O over de impact van corona op de drugscriminaliteit
De coronacrisis heeft aan veel sectoren (grote) schade toegebracht. Er lijkt echter één sector te zijn die weinig last heeft van de coronacrisis door haar veerkracht en aanpassingsvermogen; de georganiseerde drugscriminaliteit.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Photodynamic therapy-based combinations with immunotherapy in colon cancer treatment
Promotie
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Bioorthogonal deprotection strategy to study T-cell activation and cross- presentation
Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.
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Topological decoding of biomolecular fold complexity
Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…
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Personalized drug repositioning using gene expression
Promotie
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Oratie Professor Vlijmen
Prof.Dr. Herman van Vlijmen is op 15 april 2008 aangesteld als Professor of Computational Drug Discovery bij de 'Division of Medicinal Chemistry'. Zijn oratie is op 18 mei 2009.
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Core cross-linked polymeric micelles based on polypept(o)ides: from secondary structure formation of polypeptides to functional cross-linking
This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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the Indo-Pacific through European and Japanese Cyber Diplomatic Initiatives
Lezing
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On quantum transport in flat-band materials
The studies in this thesis are focused on the physical effects in the flat band materials. The results contain the discovery of strong enhancement of RKKY spin-spin interactions with specific geometric arrangement and dynamical generation of excitonic order parameter with high magnitude.
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Lioe-Fee de Geus-Oei
Faculteit Geneeskunde
l.f.de_geus-oei@lumc.nl | +31 71 526 9111
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Nieuwe dimensie acroniem LACDR
LACDR, voorheen bekend als het acroniem voor Leiden / Amsterdam Center for Drug Research, krijgt een nieuwe dimensie. Het Leidse deel gaat verder onder een nieuwe naam met hetzelfde acroniem: Leiden Academic Centre for Drug Research.
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Pancreatic cancer: Chasing the light at the end of the tunnel
Promotie
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Untangling the immune landscape of colorectal cancer by in situ multiplex immunophenotyping
Promotie
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Partial Breast Irradiation in elderly patients with early-stage breast cancer
Promotie
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Immunosuppression in breast cancer: a closer look at regulatory T cells
Promotie
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Systems biology as a compass to understand cancer-immune interactions in humans
Promotie
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The impact of one: single cell analysis of T cell states in human cancer
Promotie
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The role of the Bone Morphogenetic Protein Pathway in Colorectal Cancer
Promotie
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TGF-β signaling dynamics in epithelial-mesenchymal plasticity of cancer cells
Promotie
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Eregalerij 2023
In 2023 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.
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European Lead Factory
Overkleeft
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Huidonderzoeker pleit voor multidisciplinaire samenwerking: ‘Ik wil expertise bundelen.'
In de dermatologie zou op grote schaal multidisciplinair moeten worden samengewerkt tussen instituten en specialisten, stelt Robert Rissmann, hoogleraar Translationele Dermatologie, in zijn oratie van 8 juli. Hij bouwt een infrastructuur om pre-klinisch en klinisch huidonderzoek prominent op de kaart…
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pharmacogenetics of systemic and intraperitoneal chemotherapy in colorectal cancer
Promotie
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Light therapy for cancer-related fatigue in (non-)Hodgkin Lymphoma Survivors
Promotie
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Supporting women with breast cancer in making an informed decision about immediate breast reconstruction
Promotie
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Sexual Health Care in Prostate Cancer for Men and their Partners
Promotie
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Colorectal cancer screening for average- and high-risk individuals Beyond one-size-fits-all
Promotie
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Computational modeling of pharmacokinetics and tumor dynamics to guide anti-cancer treatment
Promotie
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Molecular imaging of pancreatic and rectal cancer - Towards optimized detection and response prediction
Promotie
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Text-mining real-world data to evaluate systemic anti-cancer therapy
Promotie
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Robust Estimation using Aggregated Data for Urban policy making (READ-URBAN)
Read-Urban was een eerste project om te onderzoeken of beleidsaanbevelingen gedaan kunnen worden met behulp van linked dataverzamelingen en data science en om ervaring op te doen met de succesfactoren voor een dergelijk proces.
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…