1,237 zoekresultaten voor “colonial development” in de Publieke website
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Chemical tools to monitor and control proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Education and Child Studies (MSc)
In de masteropleiding Education and Child Studies kies je een specialisatie in één van de deeldisciplines van de pedagogische wetenschappen. In alle specialisaties staat de wetenschappelijke vorming van studenten voorop.
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Empathic or anxious mistakes?
A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments
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Synthesis of well-defined ADP-Ribosylated biomolecules
Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov
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Onderwijs
De vakken die het VVI aanbiedt zijn onderdeel van het bredere onderwijsprogramma van de Faculteit der Rechtsgeleerdheid, dat programma’s aanbiedt op bachelor- (LLB) en masterniveau (LLM, Advanced Studies, PhD). Het instituut geeft een in Europa uniek MSc programma Law and Society: Governance and Global…
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Emerging approaches to study cell-cell interactions
The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.
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External Knowledge Absorption in Chinese SMEs
Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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Towards Photocatalytic Water Splitting in Homogeneous Solutions Using Molecular Metalloporphyrin Photosensitizers and Catalysts
Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…
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Crossing boundaries
Celebrating 20 years of environmental research in Cagayan Valley and Sierra Madre
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Evolutionary molecular dynamics
This thesis introduces the concept of
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Wiskundig model helpt ontstaan van wervels en ribben te verklaren
Leidse wiskundig biologen hebben een model ontwikkeld dat helpt verklaren hoe onder meer de ruggengraat en de wervels ontstaan in de embryonale ontwikkeling. Hetzelfde proces, maar dan andersom, speelt een sleutelrol bij de uitzaaiing van kanker. Publicatie in iScience.
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Duurzaamheid in onderwijs
In het onderwijs bieden wij alle studenten de mogelijkheid om kennis te maken met duurzaamheidsthema’s en –vraagstukken, waar mogelijk aansluitend bij de inhoud van hun opleiding.
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Duurzaamheid in onderwijs
De universiteit streeft ernaar dat alle studenten in hun opleiding kennismaken met duurzaamheidsthema’s en -vraagstukken, die zoveel mogelijk aansluiten bij de inhoud van hun opleiding.
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Political discourses and the securitization of democracy in post-1991 Ethiopia
This thesis attempts to interrogate post-1991-2015 political development in Ethiopia, focusing on the political discourses espoused by the government and opposition, using the discourse analysis method and securitization theory.
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Onderwijs
De programmagroep Opvoeding en Ontwikkeling is verantwoordelijk voor onderwijs op zowel bachelor- als masterniveau, met speciale aandacht voor opvoeding en ontwikkeling.
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Indicators for "decoupling"
Indicators to measure progress in de-linking economic growth and environmental pressure.
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Culturele Antropologie en Ontwikkelingssociologie
Wij bestuderen de dagelijkse praktijk van individuen, groepen en gemeenschappen - zowel in Nederland als wereldwijd - om ze te plaatsen binnen de complexe processen van sociale en globale ontwikkeling. In Leiden zijn we gespecialiseerd in de gevolgen van globalisering op het gebied van milieu, sociale…
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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CO2-Calculator
Development of GHG calculator for bio-electricity and heat.
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Benoeming Judi Mesman: Hoogleraar Interdisciplinary study of societal challenges
Prof. dr. Judi Mesman is benoemd tot hoogleraar interdisciplinary study of societal challenges, een gedeelde leerstoel tussen de faculteiten Governance and Global Affairs (FGGA) en Sociale Wetenschappen (FSW) van de Universiteit Leiden.
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Indringende beelden en verhalen over reizend erfgoed in Oude UB
Hoe vieren Nepalese ballingen in Engeland hun feesten? Wat doen Noord-Koreaanse monumenten in Zimbabwe? De tentoonstelling ‘Heritage on the Move’ laat zien wat er met culturen gebeurt onder invloed van migratie. Van 3 december tot 7 januari te zien in de Oude UB.
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Development matters – Longitudinale ontwikkeling van hersenen en gedrag
Congres/symposium
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Public International Law (Advanced LL.M.)
Leiden University’s Advanced Studies in Public International Law offers two specialisations: International Criminal Law and Peace, Justice, and Development.
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Vervolgopleidingen
Volg een Masteropleiding na het behalen van je Bachelor Pedagogische Wetenschappen.
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Aanpassen aan klimaatverandering: door mutatie kunnen meelkevers zich sneller ontwikkelen
Biologen vonden een mutatie in meelkevers die ervoor zorgt dat ze zich sneller ontwikkelen. Het onderzoek is gepubliceerd in Nature Ecology and Evolution.
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Nieuwe planten produceren zonder zaaien
Zonder een gewas opnieuw te zaaien toch nakomelingen produceren, die zelfs groter kunnen zijn dan de ouderplant. Volgens Leidse onderzoekers is dat mogelijk door het overstimuleren van één gen. Daarmee verjongt een cel en gaat deze terug naar de embryonale fase.
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Gevaarlijke microben in lager veiligheidslevel lab? Met een nieuwe techniek zou het kunnen
Onderzoekers moeten in een gespecialiseerde omgeving werken zodra ze aan de slag gaan met gevaarlijke bacteriën en virussen. Alleen in laboratoria met een hoog bio-veiligheidsniveau mogen ze deze microben bestuderen. Helaas zijn dure microscopen nodig om de microben goed te bekijken, maar is dat soms…
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Policy Review on Decoupling
Development of indicators to assess decoupling of economic development and environmental pressure in the EU-25 and AC-3 countries.
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SMALL Savannah : an information system for the integrated analysis of land use change in the Far North of Cameroon
Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan
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Learning My Way
Learning about My meaningful Way through life and profession.
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Bloomington Grove Kickapoo Creek Restoration to Enhance Biodiversity
Does a high quality prairie restoration in an urban/agricultural landscape provide invertebrates necessary for a sustainable ecosystem?
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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X-ray spectroscopy of merging galaxy clusters
This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Analysis of Energy Systems
The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.
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Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…