943 zoekresultaten voor “war on drugs” in de Publieke website
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Reflections on the Russia-Ukraine War
Bas Rietjens en zijn collega's onderzochten de oorlog tussen Rusland en Oekraïne en onderzochten deze veelvoud aan facetten en hun onderlinge verbanden.
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Reden Valencia Libo-on
Faculteit der Geesteswetenschappen
r.libo-on@hum.leidenuniv.nl | +31 71 527 2125
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Photo-activated drug delivery systems
O-Nitrobenzyl groepen worden veel gebruikt als moleculaire beschermgroepen die je met licht kunt verwijderen.
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War, Peace and Justice
De onderzoeksgroep War, Peace and Justice brengt wetenschappers, onderzoekers en (voormalige) mensen uit de praktijk van het veld samen om vraagstukken te onderzoeken, zoals de drijfveren, de aard en de (nieuwe) dynamieken van oorlog en conflict, integrale aanpak van de bevordering tot duurzame vrede,…
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guard? Evaluating how external experts in Germany warned about Russia’s war on Ukraine
Dit artikel van Michaels onderzoekt hoe externe expertise de productie van inlichtingen en crisisbesluitvorming kan ondersteunen met de casus van Duitsland.
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Modern Drug Discovery
How are new drugs developed? This question is central to the Minor Modern Drug Discovery (MDD), which covers the entire trajectory from disease to drug molecule and vice versa. The various research groups involved offer a complementary and interdisciplinary perspective by connecting the diverse subjects…
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Bijzondere leerstoel War Studies
Het primaire doel van de leerstoel is het uitvoeren en bevorderen van wetenschappelijk onderzoek naar de rol van het militaire instrument in hedendaagse conflicten en het verhogen van de kennis daarover in de Nederlandse maatschappij.
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The impact of obesity on the pharmacokinetics of drugs in adolescents and adults
Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Drug Discovery & Safety
In het onderzoeksprogramma Drug Discovery & Safety zijn we geïnteresseerd in de werkzaamheid en veiligheid van nieuwe medicijnen en nieuwe manieren om deze aspecten te bepalen. Daarvoor combineren we geavanceerde imaging en high-throughput screening technieken met computationele aanpakken zoals chem-…
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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Drug Discovery and Safety (MSc)
In deze opleiding ontwikkel je je onderzoek skills en verbreed je je kennis over de meest moderne en geavanceerde technieken die je nodig hebt als onderzoeker op het gebied van target finding en het ontwerp en de synthese van nieuwe geneesmiddelen.
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Assistant Professor in War Studies (1 fte)
Governance and Global Affairs, Institute of Security and Global Affairs, War, Peace and Justice
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Ginsenosides as selective glucocorticoid drugs: agonists, antagonists, and prodrugs
Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
- Cultural Memory of War and Conflict
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Advanced in vitro models for studying drug induced toxicity
Promotor: B.van de Water, Co-promotor: L.S.Price
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Activity-based protein profiling in drug discovery
In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.
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PhD candidate combinatorial drug discovery with macrocycles
Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)
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Why Minor Powers Risk Wars with Major Powers: A Comparative Study of the Post-Cold War Era
Aan de hand van een reeks case studies in Irak, Moldavië en Servië gedurende het post-Koude Oorlogstijdperk, onderzoekt dit boek asymmetrische conflicten waarbij de strijdende partijen een grote ongelijkheid in machtsposities vertonen.
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Leiden Academic Centre for Drug Research
Het ontwikkelen van nieuwe medicijnen is een complex proces waarbij veel partijen samenwerken. De onderzoekers van het LACDR zetten zich dagelijks in voor nieuwe, betere, efficiëntere en makkelijker produceerbare medicijnen. Het instituut werkt nauw samen met het LUMC, met bedrijven op het Leiden Bio-Science…
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PhD Fellow War peace and Justice
Governance and Global Affairs, Institute of Security and Global Affairs
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Computational Approaches to Disease, Signaling and Drug Targets
The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.
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Pharmacogenomics in drug development: implementation and application of PKPD model based approaches
Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh
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mRNA and drug delivery with lipid-based nanoparticles
This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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vesicles: An efficient membrane biophysical tool and its application in drug delivery studies
Promotor: A. Kros
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Novel target engagement biomarkers for better drug candidates
M van der Stelt
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Call for Papers: Perceptions of Just War in the Middle Ages (IMC 2025)
The Research Training Group “Byzantium and the Euro-Mediterranean Cultures of War” invites scholars to submit paper proposals for a series of sessions on “Perceptions of Just War in the Middle Ages” at the IMC 2025. These sessions aim to explore the diverse theological, philosophical, legal, and cultural…
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Dutch Post-war Fiction Film through a Lens of Psychoanalysis
Deze week verscheen 'Dutch Post-war Fiction Film through a Lens of Psychoanalysis' van Peter Verstraten bij Amsterdam University Press, het vervolg op Humour and Irony in Dutch Post-war Fiction Film uit 2016. Elk hoofdstuk in zijn 482 pagina's tellende nieuwe studie begint met een titel van Fons Rademakers…
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Forces and Innovations in Security Governance in Mozambique’s Civil War
Political scientist Corinna Jentzsch (Leiden University) about the organisation of rebel and government auxiliaries in the civil war in Mozambique (1976–1992).
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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namic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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Pharmacogenomics in Drug Development: Implementation and Application of PKPD Model Based Approaches
Model based approaches, integrating physiological parameters or linking exposure with response, are powerful tools to quantify and evaluate the impact of genetic differences that are reflected as variability of drug exposure and/or clinical response(s). This thesis “Pharmacogenomics in Drug Development: …
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Personalised pharmacotherapy in paediatric epilepsy : the path to rational drug and dose selection
The path to rational drug and dose selection
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Corinna Jentzsch, 'Here are 4 reasons why Mozambique isn’t a post-war success story' (blog)
Politicoloog Corinna Jentzsch (Universiteit Leiden) legt uit waarom Mozambique (nog) geen succesverhaal is.