6 zoekresultaten voor “natural products” in de Publieke website
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Next generation bacitracin: reimagining a classic antibiotic
Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…
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Hannah AugustijnWiskunde en Natuurwetenschappen
h.e.augustijn@biology.leidenuniv.nl | 071 5274791
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Anthracycline biosynthesis in Streptomyces: engineering, resistance and antimicrobial activity
Actinobacteria are well known for the production of bioactive natural products, many of which have applications in the fields of human, animal and plant health. Subject of this thesis are the anthracyclines, glycosylated aromatic polyketides with potent anticancer activity.
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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Niels van der WindtWiskunde en Natuurwetenschappen
n.van.der.windt@cml.leidenuniv.nl | 071 5272727
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Robert VerpoorteWiskunde en Natuurwetenschappen
verpoort@chem.leidenuniv.nl | +31 71 527 4528