Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Het immuunsysteem beschermt ons tegen ziekten, maar soms gaat het mis. Dan dringt er toch een vijand binnen of valt het immuunsysteem ons eigen lichaam aan, waardoor we ziek worden. Artsen en onderzoekers van het Leids Universitair Medisch Centrum (LUMC) willen het immuunsysteem zodanig sturen, dat…

Promotor: H.P. Spaink, Co-Promotor: A.H. Meijer

Tuberculosebacteriën en andere intracellulaire pathogenen gebruiken immuuncellen als paard van Troje om zich in hun gastheer te verspreiden. Annemarie Meijer, hoogleraar immunobiologie, vertelt hoe onderzoek naar mechanismen van aangeboren immuniteit in zebravissen helpt om nieuwe behandelingsmethoden…

Promotor: Prof.dr. J.N. Kok

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Chiodo

Josien de Klerk en Tennessee Miller onderzochten de interactie tussen de ziekte- en herstelervaringen van studenten en de academische werkcultuur in deze context.

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Het Amerikaanse hooggerechtshof oordeelde op 1 juli dat een president tijdens hun ambtsperiode een zekere immuniteit heeft. Zij zijn onschendbaar in geval van ‘officiële handelingen’. Tessa van Buchem uit haar zorgen en kritiek in het FD.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Vrouwenkiesrecht, eenheidsworst en gloeilampen: drie ongebruikelijke gevolgen van de Eerste Wereldoorlog. Henk te Velde, historicus en houder van de leerstoel Vaderlandse Geschiedenis, sprak met Scientias.nl over hoe de Eerste Wereldoorlog het (dagelijkse) leven in Nederland beïnvloedde.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) hebben 2,3 miljoen euro ontvangen van het EU Horizon 2020-programma en de Wellcome Trust om met internationale partners te werken aan een vaccin voor infectie met de parasitaire worm Schistosoma.

Control of infectious diseases poses continuous challenges for human health.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

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Promotores: A.H. Meijer, H.P. Spaink

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

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The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Onderzoekers van het Leids Universitair Medisch Centrum (LUMC) en het Radboudumc hebben groen licht gekregen om vrijwilligers opzettelijk met malaria te besmetten, om een veelbelovend vaccin bij hen te testen.

De infectieziektes malaria en tuberculose zijn verantwoordelijk voor 2.1 miljoen dodelijke slachtoffers per jaar. Op dit moment testen Leidse onderzoekers een nieuw tuberculosevaccin.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.

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