Nature, nurture and neural mechanisms of social emotion regulation in childhood

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotie

Welke factoren (mens-dimensie en carnivoor-gerelateerd) zijn bepalend voor de menselijke tolerantie ten opzichte van grote carnivoren en voor de overlevingskansen van grote carnivoren in bossen met meervoudig gebruik?

Program for postgraduate research master seminar 'Current Issues in Religious Studies and Western Esotericism' 2024–2025 is online

Studievoorlichting

Review of new technical decisionsupport systems in the environmental field, and application in water management decission processes.

Religious Studies at the University of Amsterdam organises a postgraduate seminar on current issues in religious studies and western esotericism. You can find the programme for the year 2023-2024 below.

This dissertation presents a new perspective on the life, work and character of the Dutch physical chemist Jacobus Henricus van ’t Hoff, first recipient of the Nobel Prize in Chemistry, and one of the most important and colourful scientists in Dutch history. The image of Van ’t Hoff that emerges from…

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

This thesis discusses the discovery potential of Intensity Frontier experiments.

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Studievoorlichting

Studievoorlichting

Een bachelor Security Studies doen en tegelijkertijd twee bedrijven opzetten en runnen: student Mohamed Sulaiman is altijd aan het werk. Maar dat doet hij met plezier en toewijding. Bij ondernemershub PLNT Den Haag krijgt hij hulp en doet hij inspiratie op.

The extensive use of electronic communication channels and other devices has opened new possibilities for collecting data on human behavior. This information is sometimes openly accessible, but largely part of administrative registration systems that are not open to the broader public. The data provides…

CREEA is a FP7 project on compiling and refining environmental and economic accounts. The project runs from April 2011 to March 2014.

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)

Safety issues of the transport and storage of Chlorine, ammonia and LPG.

This thesis consists of three chapters. Each chapter is on a different subject. However, all three chapters address issues that arise in counting arithmetically interesting objects.

Promotie

The global agri-food system plays a critical role in food security and environmental issues.

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

De Faculteit Sociale Wetenschappen van de Universiteit Leiden is van plan om een bijzondere leerstoel Workplace Pride in te stellen. De hoogleraar die de leerstoel zou bekleden gaat onderzoek doen naar de verbetering van de positie van lesbische vrouwen, homoseksuele mannen, biseksuelen en transgenders…

Career Event

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

The Economics and Governance specialisation of the Master in Public Administration teaches you to formulate problem-solving approaches to concrete policy issues found at the intersection between economics and public administration. This specialisation is a unique joint offering of the Department of…

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

A critical look at the impact assessment modelling of metals in Life Cycle Impact Assessment and improvement options.

Graduation MIRD Class of 2024: 'The world is better off with students like this'

The LUGO Press is a student publication forum, rooted in academia and journalistic practices and published by the Leiden University Green Office.

The minor Artificial Intelligence & Business (previous name Science, Business, and Innovation) will provide you with knowledge and skills in the area of management and entrepreneurship, with a focus on issues in technology-driven companies.

Security and safety challenges rank among the most pressing issues of modern times. Challenges such as cyber-crime, terrorism, and environmental disasters impact the lives of millions across the globe. The course will introduce you to this broad theme in an increasingly complex world.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).