Om een nieuwe impuls aan de verdere intensivering van interdisciplinaire samenwerking binnen het SSH-domein te geven en de hoge kwaliteit van het gedragswetenschappelijk onderzoek binnen de Universiteit Leiden te kunnen blijven garanderen, zijn de Social Sciences en Humanities Labs (SSH-labs) ontwikkeld.…

Nature, nurture and neural mechanisms of social emotion regulation in childhood

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Kunst en vrije tijd, Kunst en vrije tijd

The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.

Promotie

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Welke factoren (mens-dimensie en carnivoor-gerelateerd) zijn bepalend voor de menselijke tolerantie ten opzichte van grote carnivoren en voor de overlevingskansen van grote carnivoren in bossen met meervoudig gebruik?

Op de tweede verdieping van het Sylvius Laboratorium worden nieuwe labs gebouwd voor onderzoekers van de Faculteiten der Sociale Wetenschappen en Geesteswetenschappen. Na een geslaagde aanbesteding is de bouw inmiddels officieel van start gegaan.

Chapter 2 describes a post-synthetic methodology to introduce a fluorescent label in highly lipophilic, Pam3Cys based conjugates.

Working Group

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Er was veel belangstelling. Onder het oog van bijna honderd onderzoekers, ondersteunende collega’s en Martijn Ridderbos , vice-voorzitter College van Bestuur, opende Lotte van Dillen, onderzoeksdirecteur Psychologie en Saskia Goedhard, directeur Bedrijfsvoering Geesteswetenschappen samen op ludieke…

This thesis discusses the discovery potential of Intensity Frontier experiments.

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

Promotor: Prof.dr. M. de Jong, Co-Promotor: A.J. Heijboer

Een bachelor Security Studies doen en tegelijkertijd twee bedrijven opzetten en runnen: student Mohamed Sulaiman is altijd aan het werk. Maar dat doet hij met plezier en toewijding. Bij ondernemershub PLNT Den Haag krijgt hij hulp en doet hij inspiratie op.

Hoe en in welke mate beïnvloedt AI de vertegenwoordiging van burgers in openbare dienstverlening en interacties tussen staat en burger?

Op 8 november 2021 organiseerde YAL het succesvolle symposium Interdisciplinair onderzoek: uitdagingen en kansen.

Promotie

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

This thesis describes the development of a variety of mannosylated conjugates. Antigen presenting cells bear mannoside recognizing receptors that actively transport antigen into the cell. This thesis exploits this feature for the development of improved vaccines.

Graduation MIRD Class of 2024: 'The world is better off with students like this'

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Membrane fusion is a vital process in living organisms and is mediated by zipper-like proteins.

De Swahilikust kent een lange geschiedenis van transoceanische islamitische verbindingen die teruggaat tot de 25e eeuw. Toch heeft de boekdrukkunst de wereld veranderd; niet alleen de onze. In dit project worden unieke vormen en archieven van intellectuele geschiedenis ontrafeld die vanuit Zuid-Zuid-verbindingen…

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

Promotie

Studievoorlichting

De meeste studies van de Faculteit der Sociale Wetenschappen zijn te volgen in het Pieter de la Courtgebouw aan de Wassenaarseweg in Leiden. Naast deze locatie zijn een aantal opleidingen te volgen in het Wijnhavengebouw in Den Haag, op de Campus Den Haag.

Studievoorlichting, On Campus Experience

Where and how are critical materials currently used and how can this information be used to develop scenarios about their future demand.

Studievoorlichting

Studievoorlichting, Online Experience

Promotor: A. Kros

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

One of the key discoveries in exoplanet research over the past decade is the abundance of small planets in our Milky Way. Despite their high numbers, our understanding of their atmospheres remains limited, and it is unknown if they possess atmospheres at all.

Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

My work focuses on a class of astronomical objects called protoplanetary disks.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.