Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Promotor: Prof.dr. S. Portegies Zwart

LIACS is a partner in RISE_SMA, an interdisciplinary, international network combining excellent scholars and practitioners to enable vigorous knowledge sharing and to develop solutions for contemporary challenges for Social Media Analytics (SMA).

Promotor: J.S. Kaastra Co-promotor: E. Constantini

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Promotor: Prof.dr. D. Bouwmeester, Co-Promotor: M.J.A. de Dood

Promotor: Prof.dr. E. F. van Dishoeck

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…

Promotor: R. Gill, Co-promotor: P. Massart

Identification of the products or product groups that have the greatest environmental impact from a life-cycle perspective using environmentally extended input-output analysis.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

Promotor: S.M. Verduyn Lunel

Promotores: J. Zaanen, A. Parnachev

Promotor: T.H. Oosterkamp

Promotor: W. Jiskoot, Co-promotor: H.A. Every

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

The Institute of Environmental Sciences has carried out and participates in several projects that deal with the analysis of energy systems.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotor: R.D. Gill, F. Taroni

Dit op casestudies gebaseerde Engelstalige boek over multivariate analyse voor gevorderde studenten in de geesteswetenschappen legt de nadruk op beschrijvende, exploratieve analyses van verschillende soorten datasets uit een breed scala van subdisciplines, waarbij het gebruik van multivariate analyse…

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

Schistosomiasis is an acute and chronic disease caused by blood dwelling parasitic trematodes of the genus Schistosoma, and it is classified as the second most socioeconomically devastating parasitic disease, second only to malaria.

Promotor: Prof.dr. P.C. van Welzen

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

Promotor: K.E. Schalm, Co-promotor: S.S. Lee

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotor: A. Kros

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

One of the most important puzzles in modern astrophysics is the nature of dark matter.

Promotor: T. Schmidt

Sustainable energy from wind and solar is most readily available near the sea.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller