The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

De Engelstalige master Biomedical Sciences in Leiden gaat over het bestuderen van normale en abnormale processen in het menselijk lichaam. Zo leer je ziektes beter te begrijpen, bestaande therapieën te verbeteren of nieuwe therapieën te bedenken. Naast het algemene programma dat zich toespitst op het…

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

Een wetenschappelijk onderzoek naar de versterking van de verantwoordelijkheid van gecontroleerde entiteiten zelf rondom de accountantscontrole en de jaarverslaggeving.

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Promotor: Prof.dr. E. Smets, M. Stech

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

Promotores: T.H. Oosterkamp, N. de Jonge

Taking as a point of departure the Italian American community in Boston and its process of collective remembrance surrounding Saint Anthony’s Feast, we addressing the limits and potential of montage.

The sequence-dependence of biomolecular interactions involving nucleic acids and proteins is essential for numerous processes inside the cell. Insights into the underlying molecular mechanisms have been obtained using various biochemical and biophysical methods on two different levels — bulk and sin…

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

Op deze pagina vindt u de opnames van de online This Week's Discoveries vanaf 12 mei 2020 en een lijst sprekers vanaf oktober 2015.

Hoe kun je virussen als medicijn laten werken? Hoe kunnen bacteriën schadelijke stoffen in het milieu afbreken? Hoe worden algen omgevormd tot producenten van biobrandstof? Dit zijn typische vragen die je bij de opleiding Life Science & Technology behandeld. Je leert doorgronden hoe de cel is opgebouwd…

Hoe kun je virussen als medicijn laten werken? Hoe kunnen bacteriën schadelijke stoffen in het milieu afbreken? Hoe worden algen omgevormd tot producenten van biobrandstof? Dit zijn typische vragen die je bij de opleiding Life Science & Technology behandeld. Je leert doorgronden hoe de cel is opgebouwd…

Big Science, commonly defined as conventional science made big in three dimensions, namely organizations, machines, and politics, brings a plethora of different stakeholders together, often for a long period of time. This includes policymakers, scientists, (scientific) managers as well as local “host”…

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

De afdeling Environmental Biology (CML-EB) houdt zich bezig met vraagstukken rondom biodiversiteit en natuurlijke hulpbronnen op het platteland in westerse en niet-westerse gebieden.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Lezing, Faculty Lecture

Culturele Antropologie en Ontwikkelingssociologie in Leiden staat bekend om haar internationaal georiënteerde expertise. Met een breed scala aan theoretische, methodologische en regionale onderwerpen, biedt de opleiding een sterk gefundeerd en verdiepend programma.

De onderliggende gedachte van de Masteropleiding is dat je (1) begint met een concrete uitdaging, (2) dan vanuit wetenschappelijke perspectieven reflecteert op de uitdaging, (3) om vervolgens de academische kennis weer toe te passen op (zelfgekozen) maatschappelijke, economische en bestuurlijke vra…

Alles met betrekking tot politiek, bestuur en communicatie valt samen in dit domein. Als cursist voor de bekende Public Affairs basis- en verdiepingsleergang wordt de verbinding tussen de politieke en maatschappelijke omgeving gelegd en krijg je inzicht in politieke en bestuurlijke processen. Daarnaast…

Promotores: Prof.dr. J. Zaanen, Prof.dr. K.E. Schalm

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Remus Dame

Op 10 oktober 2019 verdedigde Laure d'Hondt haar proefschrift 'Addressing Industrial Pollution in Indonesia. The Nexus between Regulation and Redress seeking'. Het promotieonderzoek is begeleid door promotor prof.dr. A.W. Bedner.

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Op 7 februari 2019 verdedigde Helena Ursic-Vrabec haar proefschrift 'Uncontrollable: Data subject rights and the data- driven economy'. Het promotieonderzoek is begeleid door promotor prof. dr. S. van der Hof.

Promotor: Prof.dr. G.J. Kroes

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Promotor: J.M. van den Broek Co-promotor: M.C. de Vries

Het twaalver-sjiisme speelde een centrale rol in de these en antithese waaruit de islam ontstond, en is vandaag de dag nog steeds zeer invloedrijk. Het doel van project ImBod is om de eerste complete sociale geschiedenis van het imamaat te schrijven.

Diplomatiek onderhandelen is een moeilijk te begrijpen en te beheersen proces. Toch is het onderhandelen tussen staten en in internationale organisaties van levensbelang voor het functioneren van het internationale bestel.

Creating information portals for support of European environmental policy.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

BSc-programma’s: ‘Political Science’, ‘International Relations and Organisations’. MSc-opleiding: Political Science, met specialisaties ‘International Organisation’; ‘Dutch Politics; ‘Nationalism, Ethnic Conflict, and Development’; ‘International Politics’; ‘Political Legitimacy and Justice’; ‘Democracy…

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich