Snelle en goedkope chips die extreem kleine hoeveelheden vloeistof (microfluïden) analyseren vormen de kern van gepersonaliseerde gezondheidszorg. Maar het ‘laboratorium op een chip’ is nog niet effectief genoeg. Dr. Paul Vulto en zijn onderzoeksteam ontwikkelden een techniek die het gebruik van microfluïdische…

Rechtsgeleerdheid

Het documenteren en beschrijven van de talen van de wereld.

Lezing, Studium Generale

People in motion. Dat is het thema van het festival Voice4Thought dat van 21 tot 25 september in Leiden plaatsvindt. Debat, zang, kunst, workshops, een scholierenconferentie. Alles draait om de ontmoeting.

Promotores: H.W. Lenstra, K. Belabas (University of Bordeaux)

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Indicators to measure progress in de-linking economic growth and environmental pressure.

Heart failure is a major health care problem with high mortality.

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

Promotores: P. Stevenhagen, L. van Geemen (Università degli studi di Milano), Co-Supervisor: Ronald M. van Luijk

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

An Active Galactic Nucleus (AGN) is a highly luminous region at the center of a galaxy, powered by the accretion into a supermassive black hole and emitting energy from radio waves to gamma rays, often outshining the host galaxy.

Stellar feedback is a crucial ingredient in the evolution of galaxies.

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

Promotores: B. Erez, P. Stevenhagen, Co-Promotor: B. de Smit

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M.R.V. Chaudron, Co-Promotor: M.T.M. Emmerich

Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Lezing, NGL-lezing

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

EU Universe Awareness (EU-UNAWE), een educatief sterrenkundeproject van de Leidse Sterrewacht, heeft gloednieuw lesmateriaal ontwikkeld: Universe in a Box. Het toegankelijke lespakket is ontworpen om de moeilijke en soms abstracte concepten van sterrenkunde uit te leggen aan jonge kinderen van 4 tot…

Het project Universe Awareness (UNAWE) van de Universiteit Leiden organiseert een Kickstarter crowdfunding campagne om de lespakketten van 'Universe in a Box', een lespakket voor sterrenkunde, zoveel mogelijk te kunnen verspreiden onder kansarme gemeenschappen over de hele wereld. De campagne werd gelanceerd…

Emeritus hoogleraar Ferdinand Feldbrugge bood op 29 november 2017 het door Brill-Nijhoff uitgegeven “A History of Russian Law” aan aan de decaan van de faculteit, Joanne van der Leun, het hoofd van de universiteitsbibliotheek Kurt De Belder en aan de Eerste Secretaris van de Russische ambassade, Yuri…

Public Administration is a major refereed journal publishing articles on public administration, public policy and public management.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Promotor: G.J.B. van Ommen

The Minor in Business Administration teaches business knowledge and skills that are important for your future career.

Wiskunde en Natuurwetenschappen

Lezing, Lezing onderdeel van serie

Lorenza Colzato wil onderzoeken of het gebruik van probiotica en tryptofaan de sociaal-cognitieve achteruitgang die optreedt bij het ouder worden, kan vertragen. Daarvoor ontvangt Colzato samen met haar collega's in Duitsland en Spanje een JPI 'A Healthy Diet for A Healthy Life' Joint Transnational…

De mensenhandel van Eritrese vluchtelingen is een booming business waarin miljarden worden verdiend met het smokkelen van mensen, maar ook door bedreiging, gijzelingen en zelfs marteling. Moderne communicatiemiddelen zoals geld overmaken via mobiele telefoons spelen een vitale rol hierin, concluderen…

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Call for Application for a Monumenta Germaniae Historica (MGH) Fellowship

Masterstudent African Studies Eline Sleurink loopt momenteel drie maanden stage in Accra, de hoofdstad van Ghana. Ze deelt haar avonturen op The Leidener, een blog dat wordt gerund door internationale studenten aan de Universiteit Leiden.