The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.

Op dinsdag 2 mei 2017 is de H.A.Brasz scriptieprijs van de Vereniging voor Bestuurskunde uitgereikt aan Joanne Langkamp , als masterstudent afgestudeerd aan de Universiteit Leiden bij Joris van der Voet en Sandra Groeneveld. Joris van der Voet nam de prijs voor haar in ontvangst.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

Development of an aggregated impact indicator to measure decoupling.

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan

Promotor: P.M. Brakefield

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.

World Teachers Festival 2024 - Celebrating and exploring language, culture, diversity and criticality in teaching and learning

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Optimization tasks in practice have multifaceted challenges as they are often black box, subject to multiple equality and inequality constraints and expensive to evaluate.

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

Lezing, Public Ethics Talks

Psychologen uit de onderzoeksgroep van Mariska Kret vertellen over fundamenteel onderzoek naar emoties bij Orang-Oetans in Apenheul. De dierentuin heeft een praktische toepassing op het oog: de juiste match vinden in een internationaal fokprogramma voor apen. Nationaal en internationaal pakken de media…

Promotor: E.F. Smets, Co-promotor: J. Geml

Universe in a Box is erkend voor zijn educatieve waarde, door het Europese netwerk van Wetenschapseducatie (Scientix).

Promotor: H.W. Lenstra

Dr. Iris van Ooijen publiceert in februari een artikel in Appetite, getiteld “Signalling product healthiness through symbolic package cues: Effects of package shape and goal congruence on consumer behavior”, in samenwerking met collega’s van de Universiteit van Amsterdam en de Vrije Universiteit Ams…

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

Athletes always strive for the top. How can data scientists assist them in improving their performance? During the seminar Data Science and Sports, the possibilities and challenges of collaboration between these two worlds were discussed.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

New master specialisation: Economics and Governance

The Gennadius Library of the American School of Classical Studies at Athens announces the summer session focused on the study of Medieval Greek, from June 26 to July 27, 2023. The Library invites applications for a month-long Summer Session for Medieval Greek at the Intermediate to Advanced Level. The…

A warm welcome to the students of the Master’s Programme in European Law 2018-2019. This year, we expect around 60 students who will start this LL.M. programme, organised by the Europa Institute. Our faculty staff is excited to meet you and to teach you all aspects of European Law.

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

This PhD-thesis analyses the relationship between the parties’ choices in the CPB Netherlands Bureau for Economic Policy Analysis’ assessments of the election manifestos and coalition agreements over the period 1986-2017, and tries to explain this relationship.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Hoe vermenigvuldigen de miljoenen cellen in ons lichaam zich precies? Prof. Dogterom legt uit hoe zij een onderdeel van een cel heeft kunnen nabouwen op een chip met deeltjes ter grootte van een nanometer.

The field of science communication is very broad. Below is a list of organisations where SCS students can fulfill internships or where alumni have found jobs.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Women Writing Mexico (WWM) is a network of women and men concerned with the human rights crisis in Mexico and more specifically, with the impact of structural forms of poverty, everyday violence, and discrimination based on gender, race, social class, and ethnicity, that particularly have an impact…

Op 10 november 2021 verdedigde Carmel van Niekerk-Jacobs het proefschrift 'Realising the right to reproduce with assistance in South Africa'. Het promotieonderzoek is begeleid door prof.dr. J.J. Sloth-Nielsen en prof.dr. T. Liefaard.

Claire Weeda, Robert Stein, and Louis Sicking have published a collection of essays in honour of Em. Prof. dr. Peter Hoppenbrouwers - also the former Scientific Director of the Research School of Medieval Studies. The contributions can be consulted freely online.

Homohuwelijk, draagmoederschap, abortus. Hoe reageert het recht op dergelijke moreelgevoelige onderwerpen bij grensoverschrijdend verkeer binnen de Europese Unie? Op 4 november 2015 promoveert Nelleke Koffeman op dit onderwerp.

‘We must be in the Netherlands, because it isn’t even three o’clock yet and we have already started!’, lacht Pamela Hack, de Amerikaanse Deputy Consul General. Afgelopen week bezochten de scholieren van de Pre-Class ‘Political American History’ de nieuwe Amerikaanse ambassade in Wassenaar. Wat volgde…

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.