2,247 zoekresultaten voor “specifiek for a” in de Publieke website
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Specifiek eiwit in de hoofdrol bij ziekte van Parkinson
Met elektronspins hebben natuurkundigen het bindingsproces onderzocht van het eiwit α-synucleïne, dat wordt geassocieerd met de ziekte van Parkinson. Wat blijkt is dat het eiwit op een verrassend efficiënte manier bindt aan een hersenmembraan. Met deze in Leiden ontwikkelde methode hebben de onderzoekers…
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Remote sensing-based assessment of functional diversity for polar ecosystems
1: What is the relative importance of alfa and beta biodiversity in polar ecosystems, and how does intraspecific variation influence this? 2: How can we use remote sensing to determine functional biodiversity (within communities) in polar ecosystems? 3: Temporal and spatial scales of functional biodiversity:…
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of glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
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electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology
The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Design and synthesis of metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…
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Nu beschikbaar: Open Science - A Practical Guide for Early-Career Researchers
Dit is een praktische handleiding gericht op promovendi, Research Master studenten en early-career researchers uit alle vakgebieden. De instructies in de gids zijn bedoeld als inspiratie voor jonge onderzoekers en als hulp om Open Science te beoefenen door hun onderzoek zo open als mogelijk te delen…
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An Update and Expansion of a Meta-Analysis on Shared Book Reading
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- Revolutionary Turmoil and Structural Change - Ethiopia' s 1974 Turning Point in a Global Perspective
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Determining the most appropriate dose metrics for evaluating dose-response relationships of metal-based nanoparticles to Zebrafish embryos
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Rare Earth Supply Chain and Industrial Ecosystem: A Material Flow Assessment of European Union
1) Assess the trends in supply and production status of these critical minerals and mineral products worldwide and Europe’s dependence including on intermediate products such as permanent magnets, RE based super alloys, batteries, polishing compounds, phosphors, catalysts etc. 2) Trace the entire value…
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Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace
Op 10 juni 2021 verdedigde Merinda Stewart haar proefschrift 'Freedom of Overflight: A Study of Coastal State Jurisdiction in International Airspace'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. J.J. Rijpma.
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Managing a sustainable career in the contemporary world of work: Personal choices and contextual challenges
Op 9 juni 2020 verdedigde Maral Darouei haar proefschrift 'Managing a sustainable career in the contemporary world of work: Personal choices and contextual challenges'. Het promotieonderzoek is begeleid door promotor prof.dr. J.I. van der Rest.
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
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The electrode-electrolyte interface in CO2 reduction and H2 evolution: a multiscale approach
Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.
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A New Model of Global Governance in International Tax Law Making (GLOBTAXGOV)
Dr. Irma Mosquera Valderrama onderzoekt in haar ERC-project de rol van de OESO (Organisatie voor Economische Samenwerking en Ontwikkeling) en de EU bij de totstandkoming van internationale fiscale wetgeving en streeft ernaar voorwaarden te scheppen waaronder zowel ontwikkelde landen als ontwikkelingslanden…
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Green defense against thrips- Exploring natural products for early management of western flower thrips
As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).
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Focal-plane wavefront sensors for direct exoplanet imaging: Theory, simulations and on-sky demonstrations
One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…
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Improved hard real-time scheduling and transformations for embedded Streaming Applications
This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.
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Risk perception and interpersonal discussion on risk: A systematic literature review
Dit artikel wil een coherente basis bieden voor empirische studies naar interpersoonlijke discussies over risico's.
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Protecting Places of Worship in Europe: a Review of Literature and Future Research Trends
In deze publicatie onderzochten May Tamimova en Tahir Abbas de bestaande literatuur over geweld en haat tegen gebedshuizen.
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Online Course Anatomy of the Abdomen and the Pelvis: a journey from basic to clinic
In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.
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ASCL Seminar: Hope and uncertainty in African migration - a case study of involuntary return to Ghana
Lezing
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The niche of think tanks in a consensus – seeking and neo-corporatist policy advisory system
In dit artikel leveren Bert Fraussen en Valérie Pattyn een theoretische bijdrage aan de bestaande literatuur over beleidsadvies door zich te laten inspireren door de nichetheorie.
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The incongruity of misfit: A systematic literature review and research agenda
Dit onderzoek probeert een begrip van misfit te creëren, conceptuele kennis te vergroten, bestaande kennis te benadrukken en nieuwe onderzoeksrichtingen te schetsen.
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Why It Is Wrong to Use Student Evaluations of Professors as a Measure of Teaching Effectiveness
In this article, Eamon Aloyo argues that university supervisors should not use student evaluations of teachers as a measure of teaching effectiveness.
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Multilevel governance and responses to the COVID-19 pandemic: a systematic literature review
Dit artikel geeft een overzicht van de literatuur over de effecten van multilevel governance (MLG) op de beleidsreacties van regeringen op Covid-19.
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Addressing climate change with behavioural science: A global intervention tournament in 63 countries
Dit artikel beschrijft het ontstaan van een app die kan helpen om het klimaatbewustzijn en de actie wereldwijd te vergroten.
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in South–North Policy Learning: The Chilean Model of Pension Reform as a Lopsided Exportschlager
In dit artikel vatten Kristin Makszin en Achim Kemmerling bewijs samen over hoe het VK en de VS leren van het Chileense pensioenmodel, maar beide landen slagen er niet in krediet toe te kennen of de lessen te vervormen.
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A Framework to Navigate Eco-Labels in the Textile and Clothing Industry
Dit artikel geeft antwoord op de vraag: Hoe kunnen we de ontwikkeling van eco-labels gestructureerder en transparanter maken?
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Assist or accuse? Identifying trends in crisis communication through a bibliometric literature review
Dit artikel onderzoekt de clusters van crisiscommunicatieonderzoek in de literatuur, waarbij overlappingen en raakvlakken tussen verschillende vakgebieden worden onderzocht.
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A bioorthogonal chemistry approach to the study of biomolecules in their ultrastructural cellular context
In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.
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Sentiment Shifts and a New Approach to Strategic Narratives Analysis: Russian Rhetoric on Ukraine
Dit artikel beoordeelt de Russische retoriek ten aanzien van Oekraïne door verklaringen van het Russische ministerie van Buitenlandse Zaken te analyseren.
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OFAC, Famine, and the Sanctioning of Afghanistan: A Catastrophic Policy Success
Matthew Hoye pleit voor een regulerend analytisch perspectief om de sancties tegen Afghanistan te bekijken.
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Regulating a Revolution: Small Satellites and the Law of Outer Space
Op 18 juni 2019 verdedigde Neta Palkovitz Menashy haar proefschrift 'Regulating a Revolution: Small Satellites and the Law of Outer Space'. Het promotieonderzoek is begeleid door promotoren prof. dr. P.M.J. Mendes de Leon en prof. dr. G. Molier.
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Towards photo-CIDNP MAS NMR as a generally applicable enhancement method
Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)
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Photoinduced processes in dye-sensitized photoanodes under the spotlight: a multiscale in silico investigation
With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…
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and flow of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Breaking the witches' spell: towards steering the soil microbiome for volatile-mediated control of the root parasitic weed Striga
Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.
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Nanomaterial safety for microbially-colonized hosts: Microbiota-mediated physisorption interactions and particle-specific toxicity
The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.
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Unraveling the surface formation of regular and deuterated water in space: a combined laboratory and computational study
Promotor: Prof.dr. H.V.J. Linnartz
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Firearm Homicides in Europe: A comparison with non-firearm homicides in five European countries
This paper presents the prevalence and characteristics of firearm homicides in Denmark, Finland, the Netherlands, Sweden and Switzerland
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Understanding membrane fusion at the molecular level using a biomimetic model system
Kros
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Missing the Mark? A Typology of Lethal and Non-Lethal Firearm Violence in the Netherlands
Dit artikel verkent het complexe onderwerp vuurwapengeweld en benadrukt het belang van het opnemen van niet-dodelijke incidenten van vuurwapengeweld.
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Scenes from a Marriage: on Complex Relationship between Autoimmunity and its Environmental Triggers
Promotie
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Utopia: Universal Three-dimensiOnal Passport for process Individualization in Agriculture
Vroege opsporing van gezondheidsrisico's Landbouwvoedingsmiddelen variëren van nature in hun gedetailleerde interne structuur. Om de vroege opsporing van gezondheidsrisico's als gevolg van besmetting of ziekten te vergemakkelijken, de rijpheid te voorspellen en de verspilling te minimaliseren, is het…