Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

This thesis deals with properties of Jacobians of genus two curves that cover elliptic curves.

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Co-ordination Action for Innovation in Life-Cycle Analysis for Sustainability: deepening, broadening and leaping forward the LCA methodology.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.

In the CarbonCap project, consumption oriented technological options and policy measures are identified as an addition to the present EU and world climate policy.

Kunnen we van quantum-verrassingen quantum toepassingen maken? Kunnen we het leven onderzoeken en opbouwen vanuit de nano-schaal?

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

How can we develop and further improve life cycle impact assessment methods, characterisation factors and normalisation factors?

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Promotor: Prof.dr. T. Hankemeier

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)

Promotor: Prof.dr. C.W.J. Beenakker

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

An account of the total of material flows going in, out and through Amsterdam.

Can we develop a platform for raw materials intelligence?

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Promotor: Prof.dr. F. den Hollander, G.Maillard

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

The unit residue group, to which the present thesis is devoted, is defined using the norm-residue symbol, which Hilbert introduced into algebraic number theory in 1897.

Promotor: H.W. Lenstra

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

This thesis discusses several questions regarding the double ramification cycle as a Chow class on the moduli space of stable n-pointed genus g curves using tools from so-called logarithmic geometry.

Software development is a complex process. It is important that software products become stable and maintainable assets.

Promotor: Prof.dr. J.N. Kok, Co-promotor: A.J. Knobbe

Promotores: K.J. Batenburg, B. Koren

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Promotor: Prof.dr. T. Schmidt

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Op 17 november 2021 verdedigde Cyril-Igor Grigorieff het proefschrift 'The Regime for International Air Carrier Liability'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof.dr. V. Correia (University Paris Saclay).

This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.

Promotor: Prof.dr. J. Kuiper

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Autophagy is a fundamental degradative process, maintaining cellular homeostasis and functions in host defense against intracellular pathogens, including mycobacteria and Salmonella.