1,416 zoekresultaten voor “random work in room environmental” in de Publieke website
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Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
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Data Driven Modeling & Optimization of Industrial Processes
Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.
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Estimation and Optimization of the Performance of Polyhedral Process Networks
Promotor: Prof.dr.ir. E. Deprettere
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The symmetry of crystals and the topology of electrons
Promotor: J. Zaanen, Co-Promotor: V. Juricic
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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Morphogenesis and heterogeneity in liquid-grown streptomyces cultures
The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.
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Academy of Creative and Performing Arts
De Academy of Creative and Performing Arts is een samenwerkingsverband tussen de Leidse universiteit en de Hogeschool der Kunsten Den Haag'. (Deeltijd)studenten van de Leidse universiteit kunnen hier theoretisch en praktisch kunstvakonderwijs volgen, waarvan de studiepunten meetellen voor hun bachelor-…
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Self-assembly of flexible and rigid structures: from colloidal molecules to lattices
Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…
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Developmental effects of polystyrene nanoparticles in the chicken embryo
There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.
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Fulltime programme
Het schema hieronder geeft het curriculum weer van het eenjarige fulltime programma van de master Health, Ageing and Society in collegejaar 2024-2025.
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Above- and belowground interactions in Jacobaea vulgaris: zooming in and zooming out from a plant-soil feedback perspective
In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…
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The flux and flow of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
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Reasoning about object-oriented programs: from classes to interfaces
Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…
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Workshop The Art of Journaling
Kunst en vrije tijd, Kunst en vrije tijd
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The developing infant gut microbiota: mathematical predictions of the effects of oligosaccharides
A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.
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Bacterial glycomimetics: synthesis and applications
This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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Resolving gas-phase metallicity in galaxies
Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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Substrate adaptability of β-lactamase
The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…
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Thiosugars: reactivity, methodology and applications
Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…
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Fundamental research on the voltammetry of polycrystalline gold
Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.
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Twenty years of MIRD: four alumni speak up
Big celebration upcoming weekend: MIRD's 20th anniversary is on the cards. Four alumni from different periods tell what this unique two-year master's in International Relations and Diplomacy has brought them.
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Wetenschappelijk onderzoek met de camera van je telefoon
Onderzoekers gebruiken smartphones en andere consumentencamera’s steeds vaker voor wetenschappelijke toepassingen, zoals citizen science. Toch is het nog steeds moeilijk om gegevens van verschillende apparaten te vergelijken en combineren. Promovendus Olivier Burggraaff ontwikkelde een nieuwe, gebruiksvriendelijke…
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LCN2 Seminar februari 2023
Lezing
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The Future of Work: Opportunities and challenges of digitalization, the platform economy and flexibilization of European labour markets
Congres/symposium
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Crowdfunding voor een broedplaats van kennis
Het Lorentz Center start een crowdfundingactie voor de renovatie van hun ‘Common Room’ waar wetenschappers nieuwe ideeën uitwisselen. De ruimte wordt in het najaar van 2016 gerenoveerd voor een bedrag van € 15.000.
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Hauke Ward
Wiskunde en Natuurwetenschappen
h.ward@cml.leidenuniv.nl | +31 71 527 6808
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Seminar: POPNET Connects with Ágnes Backhausz
Lezing
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Is the WPS Agenda Working? Preventing Conflict Related Sexual Violence and Beyond
Round Table
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Everyone works better together:Rational improvements to radio- and immunotherapy combinations
Promotie
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Indeling P.J. Veth-gebouw
Naar het zich nu laat aanzien worden de instituten voor Wijsbegeerte en ACPA en het Confucius Instituut in het P.J. Veth-gebouw gehuisvest. In onderstaande plattegronden is te zien, waar zij gehuisvest worden. Ook is in de plattegronden te zien waar de collegezalen en de StudyLounge zijn.
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What Works in Suicide Prevention? Lessons from the 113 Helpline
Lezing
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LCN2 seminar February 2024
Lezing
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Arnold Tukker ontvangt eredoctoraat aan Zweedse universiteit
Als een van de eerste milieuwetenschappers ooit ontving Arnold Tukker zaterdag 12 november het eredoctoraat aan de Universiteit van Linköping. Deze Zweedse universiteit bekroont Tukker voor zijn wetenschappelijk werk om tot een circulaire economie te komen.
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'Slag om duurzaamheid win je niet bij de burgerlijke rechter'
Fossielvrij tegen KLM over greenwashing, gemeenten tegen Chemours over het lozen van PFAS, de klimaatzaken tegen Shell en de ING Bank. Voorbeelden genoeg van recente civielrechtelijke zaken over duurzaamheid. Maar heeft procederen bij de burgerlijke rechter over duurzaamheid eigenlijk wel effect?
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Machtige bedrijven bepalen het klimaatbeleid van Brazilië
Een politicus omkopen of zorgen dat vrienden op politieke posities komen: Braziliaanse energiebedrijven maken dagelijks gebruik van deze machtsstrategieën.
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Leids publieksevenement bekroond door Astronomische Unie
Het online zomerprogramma Space in Your Living Room van de Sterrewacht Leiden heeft de prijs voor Meest Innovative Evenement gewonnen bij de Astronomy@Home Awards van de Internationale Astronomische Unie. In juli en augustus 2020 konden deelnemers onder andere praten met echte astronauten en fantaseren…
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Data science and sports: a winning combination
Athletes always strive for the top. How can data scientists assist them in improving their performance? During the seminar Data Science and Sports, the possibilities and challenges of collaboration between these two worlds were discussed.
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Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
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Assembling anisotropic colloidal building blocks
This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.
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On metrics and models for multiplex networks
In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.
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Gauss's theorem on sums of 3 squares, sheaves, and Gauss composition
Promotor: Bas Edixhoven, Promotor: Qing Liu
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creatIef, Creatiever, creaTiefst? Onderzoek naar het belang en de werking van creativiteitstraining bij Bachelor ICT-studenten
This dissertation presents the results of the importance of creativity for ICT-students of Dutch universities of applied sciences (in Dutch: hogescholen), and the functioning of training courses that aim to promote creative abilities is highlighted.
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Establishing State Responsibility in the Absence of Effective Government
Op 16 juni 2020 verdedigde Andrea Varga haar proefschrift 'Establishing State Responsibility in the Absence of Effective Government'. Het promotieonderzoek is begeleid door promotoren prof. dr. N.J. Schrijver en prof. dr. F. Baetens (University of Oslo).
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Global Fields and Their L-functions
Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.
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Inhibitors and probes targeting mannanases
This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…