Extending our current arsenal of antibiotics is key to staying ahead in the arms race between humans and resistant bacteria.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Sheltering is an immediate human need and determines well-being andhealth.

Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber

This thesis covers various applications of topology in condensed matter physics and quantum information.

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

This thesis focuses on the study of transient and variable radio sources in the universe.

Curved single crystals provide variable, but well-defined surface structures.

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Promotores: C.A.J. Knibbe, D. Tibboel, Co-Promotor: P. Bruins

Promotor: A. Achúcarro, Co-Promotor: G.A. Palma

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Promotor: E. Gittenberger, Co-promotores: B.W. Hoeksema; L.P. van Ofwegen

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

Promotores:Th.J.C. van Berkel, M. van Eck

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Proefschrift van de politicoloog Luzia Helfer (Universiteit Leiden), die in Nederland en in Zwitserland onderzocht op basis van welke criteria journalisten politiek nieuws selecteren en hoe politici besluiten wel of niet te reageren op het nieuws.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

Promotor: A.P.IJzerman Co-promotor: A. Bender

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

The Low Frequency Array enables studies of low-frequency carbon radio recombination lines with unprecedented sensitivity, spectral and spatial resolution.

Promotor: K.H. Kuijken

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

The thesis deals with the study of giant radio galaxies (GRGs), which are radio galaxies of megaparsec sizes.

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Het experimentele medicijn tegen ebola, het Zmapp medicijn, is ontwikkeld met financiele steun van de Amerikaanse overheid in het kader van het Small Business Innovation Research programme. De Europese Commissie heeft geprobeerd het succes van dit programma na te bootsen. Zijn haar inspanningen adequaat…

Promotor: Prof.dr. P. Hooykaas, Co-promotor: R. Offringa

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This thesis consists of two subjects, that are both a consequence of radiation pressure.

Promotor: Prof.dr. H.V.J. Linnartz

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Transport inspectorates are looking for novel methods to identify dangerous behavior, ultimately to reduce risks associated to the movements of people and goods. We explore a data-driven approach to arrive at smart inspections of vehicles.