10,000 zoekresultaten voor “leiden” in de Publieke website
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Professional learning: what teachers want to learn
Het doel van dit promotieonderzoek was te onderzoeken wat leraren zelf willen leren. De centrale onderzoeksvraag luidde: wat, hoe en waarom willen leraren leren? En hangt dit af van hun jaren leservaring en de school waarin ze werken?
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…
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Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
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Improved Strategies for Distance Based Clustering of Objects on Subsets of Attributes in High-Dimensional Data
This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.
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Systemic Accountability of the European Border and Coast Guard
Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Making Sense of Business Failure
Op 1 juli 2020 verdedigde Niek Strohmaier zijn proefschrift 'Making Sense of Business Failure'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.A.A. Adriaanse en dr. H. Pluut.
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Hard power and the European Convention on Human Rights
Op 18 juni 2019 verdedigde Peter Kempees zijn proefschrift 'Hard power and the European Convention on Human Rights'. Het promotieonderzoek is begeleid door promotoren prof. dr. R.A. Lawson en prof. dr. H. Duffy.
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Fiscale geheimhoudingsplicht: art. 67 AWR ontrafeld
Op 14 september 2021 verdedigde Bram van der Sar zijn proefschrift 'Fiscale geheimhoudingsplicht: art. 67 AWR ontrafeld'. Het promotieonderzoek is begeleid door promotoren prof.mr.dr. J.P. Boer en prof.dr.mr. A.O. Lubbers.
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Focal-plane wavefront sensors for direct exoplanet imaging: Theory, simulations and on-sky demonstrations
One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…
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Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.
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Judgmental Adjustments in Revenue Management
Op 12 ovember 2019 verdedigde Larissa Koupriuchina haar proefschrift 'Judgmental Adjustments in Revenue Management'. Het promotieonderzoek is begeleid door promotor prof.dr. J.I. Van der Rest.
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De verzamelwoede van Martinus van Marum (1750-1837) en de ouderdom van de aarde
Promotor: F.J. van Lunteren, E. Jorin
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The individual level effect of symbolic representation: An experimental study on teacher-student gender congruence and students’ perceived abilities
Onderzoek naar representatieve bureaucratie heeft vaak de positieve prestatie-effecten bevestigd van bureaucratieën die de demografische kenmerken van hun cliënten weerspiegelen. Er is echter weinig bekend over de onderliggende mechanismen op individueel niveau die tot deze resultaten leiden.
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Een boek voor iedereen en niemand, Nietzsches Zarathoestra lezen
Nietzsches beroemdste en beruchtste boek Aldus sprak Zarathoestra is misschien het meest gelezen, maar waarschijnlijk ook het minst begrepen boek uit Nietzsches oeuvre. Zelf beschouwde hij het als zijn hoogtepunt. Hij noemde het een symfonie, een heilig boek, een vijfde evangelie en zelfs het grootste…
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Development and application of cryo-EM tools to study the ultrastructure of microbes in changing environments
Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…
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Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
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The use of computational toxicology in hazard assessment of engineered nanomaterials
Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…
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Multi-objective mixed-integer evolutionary algorithms for building spatial design
Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.
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The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age
Op 27 juni 2019 verdedigde Barry Bussey zijn proefschrift 'The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age'. Het promotieonderzoek is begeleid door promotor prof. dr. P.B. Cliteur.
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Het EUROLITHIC-project
Tegenwoordig spreken de meeste Europeanen een taal die behoort tot de Indo-Europese taalfamilie. Maar welke talen of taalfamilies werden er in Europa gesproken vóór de komst van de Indo-Europeanen? Het EUROLITHIC-project zoekt antwoorden op deze vraag.
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Impact of plant domestication on spermosphere and rhizosphere microbiome composition
Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.
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Creating Global Scenarios of Environmental Impacts with Structural Economic Models
To limit the effects of climate change, global average temperature since pre-industrial measurements are to be kept well below 2 °C preferably even at 1.5 °C.
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The Rome Statute as Evidence of Customary International Law
Op 9 april 2019 verdedigde Yudan Tan haar proefschrift 'The Rome Statute as Evidence of Customary International Law'. Het promotieonderzoek is begeleid door promotor prof. dr. W.A. Schabas.
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Stille wateren hebben diepe gronden
Op 18 januari is de studie ‘Stille wateren hebben diepe gronden – Een analyse van de inkomensverdeling en haar determinanten over de afgelopen veertig jaar’ verschenen. Op deze website kunnen de studie en het achterliggend cijfermateriaal geraadpleegd worden.
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Dynamics of the Oort Cloud and Formation of Interstellar Comets Santiago Torres Rodriguez
The solar system was formed approximately 4.56 billion years ago. Despite the numerous theories that have been developed over the years, the formation and evolution of the solar system still remain unclear.
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Militaire Geschiedenis van Nederland - De Tachtigjarige Oorlog (1568-1648)
In juni is het eerste deel van een nieuwe boekenreeks over de militaire geschiedenis van Nederland verschenen: De Tachtigjarige Oorlog (1568-1648). Van Opstand naar geregelde oorlog. Louis Sicking (Instituut voor Geschiedenis, UL) schreef mee aan het boek.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Singing is silver, hearing is gold: impacts of local FoxP1 knockdowns on auditory perception and gene expression in female zebra finches
The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.
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Compressed Σ-Protocol Theory
In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.
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Simulating the birth environment of circumstellar discs
Circumstellar discs are the reservoirs of gas and dust that surround young stars and have the potential to become planetary systems.
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Complex Patterns in Streams
The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…
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Learning-based Representations of High-dimensional CAE Models for Automotive Design Optimization
In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Understanding delinquent development from childhood into early adulthood in early onset offenders
Op 30 september 2021 verdedigde Babette van Hazebroek haar proefschrift 'Understanding delinquent development from childhood into early adulthood in early onset offenders'. Het promotieonderzoek is begeleid door promotoren prof.dr. J.W. de Keijser en prof. dr. A. Popma (VUMC).
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Hartstocht achter de horren: Haagse romans rond 1900
Rond het jaar 1900 maakten zowel de Nederlandse letteren als de stad Den Haag ingrijpende ontwikkelingen door. De romans werden moderner, experimenteler, en vooral vrijmoediger. Deze bundel bespreekt romans van bekende Haagse auteurs als Louis Couperus en Marcellus Emants, maar ook van minder bekende,…
- Aflevering 38: Johan de Witt en het Rampjaar
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The Education and Training of Public Servants
In dit boek geven de auteurs een overzicht van de geschiedenis van ambtenarenopleidingen door cases in Europa, de VS en Australië te analyseren.
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Groepsgeweldplegers en groepsgeweld. De rol van individuele kenmerken
Op 29 september 2020 verdedigde Tom van Ham zijn proefschrift 'Groepsgeweldplegers en groepsgeweld. De rol van individuele kenmerken'. Het promotieonderzoek is begeleid door promotoren prof.dr.mr. A.A.J. Blokland, prof.dr. O.M.J. Adang (RUG) en prof.dr. Th.A.H. Doreleijers (VUMC).
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Metabolomic characterization of plant exudates and their correlation with plant defense systems
Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Mononuclear spin-transition materials based on the bapbpy scaffold
Promotor: Prof.dr. E. Bouwman, Co-Promotor: S. Bonnet
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Dynamic real-time substrate feed optimization of anaerobic co-digestion plants
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)
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Contempt of court
Op 18 december 2019 verdedigde Marianne Lochs haar proefschrift 'Contempt of court'. Het promotieonderzoek is begeleid door promotoren prof.dr. C.P.M. Cleiren en prof.dr. J.H. Crijns.
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The Local Impact of a Global Court: Assessing the Impact of the International Criminal Court in Situation Countries
Op 9 januari 2019 verdedigde Marieke Wierda haar proefschrift 'The Local Impact of a Global Court: Assessing the Impact of the International Criminal Court in Situation Countries'. Het promotieonderzoek is begeleid door promotoren prof. dr. C. Stahn en prof.dr. L.J. van den Herik.
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Positive representations of algebras of continuous functions
If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.