4,298 zoekresultaten voor “proefschrift” in de Publieke website
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Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
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Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…
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Two-photon luminescence of gold nanorods: applications to single-particle tracking and spectroscopy
Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.
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Integrating Analytics with Relational Databases
The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.
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The Agta of the Northern Sierra Madre. Livelihood strategies and resilience among Philippine hunter-gatherers
Promotores: G. Persoon, R. Schefold
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Star-Forming Galaxies at the Cosmic Dawn
Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens
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Non-linear astrochemical kinetics: theory and applications
This Thesis shows discoveries in non-linear astrochemical kinetics as well as a deeper analysis of dark clouds chemistry.
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Accessible remote sensing of water
Water is all around us and is vital for all aspects of life. Studying the various compounds and life forms that inhabit natural waters lets us better understand the world around us.
- Vervolgopleidingen
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Assessing global regionalized impacts of eutrophication on freshwater fish biodiversity
Freshwater biodiversity has been threatened by eutrophication due to excessive nutrients in the environment. Releasing the freshwater species from such pressures requires efforts from industry and manufacturers to avoid emissions to vulnerable and high-risk regions.
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Models of curves: The Birch and Swinnerton-Dyer conjecture & ordinary reduction
Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.
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Interaction with sound for participatory systems and data sonification
This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.
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Kummer theory for commutative algebraic groups
This dissertation is a collection of four research articles devoted to the study of Kummer theory for commutative algebraic groups.
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Is asylum bad for men (and better for women)? Changing perspectives on female and male refugees and asylum seekers in the Netherlands in the
Deelproject van
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Deformations of nodal surfaces
Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk
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Information Diffusion Analysis in Online Social Networks based on Deep Representation Learning
With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.
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Activity-based proteomics of the endocannabinoid system
This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.
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Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…
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Chasing cosmic tau neutrinos in the abyss
In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.
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G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
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Torsion points on elliptic curves over number fields of small degree
Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent
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Turtles all the way down: multiscale simulations connecting star and planet formation
The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.
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CO2 reduction on post-transition metals and their alloys: an industrial approach
This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals
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Surface-structure dependencies in catalytic reactions
Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink
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Vervolgopleidingen
Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten een masteropleiding zoals Bio-Pharmaceutical Sciences, maar ook andere masters behoren tot de mogelijkheid. Voor een selecte groep afgestudeerde BFW-ers is doorstromen naar de masteropleiding Farmacie in Leiden mogelijk.
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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Vervolgopleidingen
Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.
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Vervolgopleidingen
Wil je een volledige academische opleiding? Dan ga je na je bachelor door met een masteropleiding. Met een masterdiploma op zak heb je meer kans op een baan op academisch niveau. Na afronding krijg je de titel Master of Arts (MA).
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Mechanism-based inhibitors and probes for neuraminidases
Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.
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Toxicity, bioaccumulation and trophic transfer of engineered nanoparticles in the aquatic environment
The findings in this thesis improve the understanding of 1) the relationship between exposure characteristics and toxicity of ENPs, 2) the joint toxic action of ENP mixtures and the comparison to metal salt mixtures, 3) how NOM affects the individual and joint toxicity of ENPs, 4) the extent of trophic…
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Electroextraction approaches for preconcentration of metabolites
In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Hunting for new physics in the primordial Universe
This thesis contributes to studying primordial cosmology theories and their detectability in future observations.
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PhD-programma's
Een promotietraject bestaat uit het doen van origineel wetenschappelijk onderzoek onder begeleiding van een hoogleraar en duurt over het algemeen vier jaar.
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Counting curves and their rational points
n this thesis we study curves. In the first half, we study moduli spaces of curves and Gromov-Witten invariants, certain kinds of curves counts. We employ logarithmic geometry for this.
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Vervolgopleidingen
Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding.
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Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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Evolutionary molecular dynamics
This thesis introduces the concept of
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Promoveren
Promoveren is de toekenning respectievelijk verwerving van de academische graad van doctor in een bepaald vak.
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Hoe een Nederlander bijdroeg aan de snelle ontwikkeling van Singapore
Frans Stoelinga verdedigde zijn proefschrift 19 november 2020.
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Agression and emotions
Cultural and individual differences
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The characteristics of a negotiated assessment procedure to promote teacher learning
Het middelbaar beroepsonderwijs (mbo) wordt gekenmerkt door drie belangrijke componenten: het leren op school, het leren op de werkplek en de verbinding daartussen. Reflectievaardigheden spelen een belangrijke rol bij die verbinding.
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Student teachers’ practical knowledge, discipline strategies, and the teacher-class relationship
De leerkracht-leerlingrelatie kan worden beschreven aan de hand van de door leerlingen ervaren mate van invloed en nabijheid van de leerkracht. Daarbij wordt met ‘invloed’ bedoeld de mate waarin de leerkracht bepaalt wat er in de klas gebeurt en met ‘nabijheid’ de emotionele afstand tussen leerkracht…
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The link between hearing loss, language, and social functioning in childhood
In Nederland komt gehoorverlies voor bij 1 tot 2 op de 1000 kinderen. In ongeveer een kwart van de gevallen is de oorzaak niet bekend. De mate van gehoorverlies kent een grote variatie. In dit proefschrift worden kinderen besproken met een gehoorverlies variërend van matig (40 dB, te vergelijken met…
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Promoveren
Zo’n 400 promovendi verdedigen elk jaar hun proefschrift aan de Universiteit Leiden, verdeeld over alle disciplines die de universiteit rijk is.
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Engaging students in the study of physics: An investigation of physics teachers' belief systems about teaching and learning physics
Dit proefschrift omvat vier deelstudies naar de inhoud en structuur van de opvattingssystemen van natuurkundedocenten over het leren en onderwijzen van natuurkunde in het voortgezet onderwijs (VO) in Nederland.
- Aflevering 41: Stephen King
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Realising the right to reproduce with assistance in South Africa
Op 10 november 2021 verdedigde Carmel van Niekerk-Jacobs het proefschrift 'Realising the right to reproduce with assistance in South Africa'. Het promotieonderzoek is begeleid door prof.dr. J.J. Sloth-Nielsen en prof.dr. T. Liefaard.
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Promoveren
Het Leiden University Centre for Linguistics (LUCL) heeft een lange traditie in onderzoek naar de talen van de wereld en beschikt over unieke taalkundige expertise. Bij het LUCL helpen we bij het ontwikkelen van interdisciplinaire benaderingen door de interactie tussen datagestuurd en theorie gestuurd…