2,255 zoekresultaten voor “the use of evidence in the policy making processen” in de Publieke website
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Electroextraction approaches for preconcentration of metabolites
In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.
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Learning class-imbalanced problems from the perspective of data intrinsic characteristics
The class-imbalance problem is a challenging classification task and is frequently encountered in real-world applications. Various techniques have been developed to improve the imbalanced classification performance theoretically and practically.
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On the random-matrix theory of Majorana fermions in topological superconductors
The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.
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Towards thermo- and superlubricity on the macroscopic scale: from nanostructure to graphene and graphite lubrication
The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.
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Explicit Computation of the Height of a Gross-Schoen Cycle
Arithmetic geometry concerns the number-theoretic properties of geometric objects defined by polynomials. Mathematicians are interested in the rational solutions to these geometric objects.
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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Young suns and infant planets: Probing the origins of solar systems
Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).
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Hydrodynamics and the quantum butterfly effect in Black Holes and large N quantum field theories
Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?
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The spin evolution of accreting and radio pulsars in binary systems
Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.
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improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Legal and policy aspects of space big data: Legal implications of the use of large amounts of space data
Promotie
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Discriminatory punishment undermines the enforcement of group cooperation
Enforcement of group cooperation fails because of discriminatory punishment, according to research by Welmer Molenmaker and colleagues. When group members have different backgrounds, punishment turns into a double-edged sword: no longer used just to prevent group exploitation, but also to break the…
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Cognitive enhancement: Toward the integration of theory and practice
Cognitive enhancement is het gebruik van elke methode of techniek met als doel het verbeteren van cognitieve prestaties.
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SAPPAO - Optimizing the flight times of airplanes using data science
Met het SAPPAO-project willen we de voorspelling van geplande vluchten nauwkeuriger en betrouwbaarder maken. De volledige naam van het project is ‘A Systems Approach towards Data Mining and Prediction in Airlines Operations’.
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Implementation of the EU Preventive Restructuring Directive Part I
In 2019 hebben het Europees Parlement en de Raad de Richtlijn Preventieve Herstructurering (2019/1023) aangenomen, die voorziet in minimale harmonisatie van onder andere preventieve herstructureringskaders (preventive restructuring frameworks, 'PRF'). Dit boek biedt verdiepende analyses van de implementatie…
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Essays on the Economics of Household Finance and Social Insurance
Promotie
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On the Benefits and Boundaries of Trust and Trustworthiness
Promotie
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The innate immune response against mycobacterial infection: analysis by a combination of light and electron microscopy
Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf
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Deepening the uncertainty dimension of environmental Life Cycle Assessment: addressing choice, future and interpretation uncertainties.
LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.
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Environmental assessment and guidance for the future offshore wind energy development
This thesis aims to address offshore wind energy (OWE)-related environmental impacts.
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Exploring the chemical space of post-translationally modified peptides in Streptomyces with machine learning
The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Suppressing a Sea of Starlight: Enabling technology for the direct imaging of exoplanets
Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik
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The integration of meta-analysis and classification & regression trees: meta-CART
In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).
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The evolution and plasticity of life histories upon variation in nutrition: on aging focused integrative approach
Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)
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Imaging polarimetry for the characterisation of exoplanets and protoplanetary discs. Scientific and technical challenges
Promotor: Prof.dr. C.U. Keller
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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The evolution of chemical diversity in plants : pyrrolizidine alkaloids and cytochrome P450s in Jacobaea
Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.
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Taxonomy, systematics, and biogeography of Ficus subsection Urostigma (Moraceae)
Promotor: Prof.dr. P.C. van Welzen
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Models of curves: The Birch and Swinnerton-Dyer conjecture & ordinary reduction
Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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The music of language: exploring grammar, prosody and rhythm perception in zebra finches and budgerigars
Promotor: C.J. ten Cate
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Gauge theory and nematic order : the rich landscape of orientational phase transition
Promotor: J. Zaanen
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Insights into the mechanism of electrocatalytic CO2 reduction and concomitant catalyst degradation pathways
This work describes several studies into the electroreduction of carbon dioxide (CO2RR), both regarding mechanistical aspects and catalyst stability considerations. Mechanistic insights into carbon-carbon bond formation on a silver catalyst are described in Ch 2, were we find an acetaldehyde-like surface…
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Lezing Frits Scholten Private Devotion & Immersive Play - The Use of 'Spiritual Toys' in the Late Middle Ages
Lezing
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Artikel Ginevra Le Moli over internationaal pandemieverdrag in The Lancet
The article deals with an issue that will be at the heart of the World Health Assembly to be held in May, namely the concept of ‘deep prevention’ and the importance of its integration in the Global Pandemic Treaty - which has been recently proposed by the European Council and currently endorsed by more…
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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Dawn of the red and dead: stellar kinematics of massive quiescent galaxies out to z = 2
Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)