1,881 zoekresultaten voor “at risk students” in de Publieke website
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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The impact of defense hormones on the interaction between plants and the soil microbial community
The soil ecosystem consists of the largest reservoir of biodiversity on Earth.
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: M. Danhof, Co-promotor: E.C.M. de Lange
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Cyclophellitol analogues for profiling of exo- and endo-glycosidases
To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.
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The formation of complex organic molecules in dense clouds-Sweet results from laboratory
Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.
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Cell-autonomous and host-dependent CXCR4 signaling in cancer metastasis: insights from a zebrafish xenograft model
Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska
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The Weight of Nations
Material outflows from industrial economies.
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An Algebra for Interaction of Cyber-Physical Components
Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Systemic Accountability of the European Border and Coast Guard
Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Multi-objective mixed-integer evolutionary algorithms for building spatial design
Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.
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Impact of plant domestication on spermosphere and rhizosphere microbiome composition
Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.
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Improved hard real-time scheduling and transformations for embedded Streaming Applications
This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Towards controlled microneedle-mediated intradermal immunization
Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.
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Bakti and Sayan traditions among the Tenggerese people in East Java: the role of indigenous institutions in integrated elderly care development
This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot
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General plant strategies and functions in wetlands: Global trait-based analyses
Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.
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Social Dimensions of Crane and Wetland Conservation in African Rural Landscapes: Insights from Kenya, Uganda and Zimbabwe
This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration
Op 11 juni 2020 verdedigde Sabine Witting haar proefschrift 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. Het promotieonderzoek is begeleid door promotoren prof.mr. J.J. Sloth-Nielsen en prof.dr.mr. S. van der Hof.
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Abiotic depletion in LCIA
Possible improvements for the assessment of abiotic depletion in LCA.
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Scheduled protocol programming
With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…
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Arabidopsis AGC3 kinases and PIN plasma membrane abundance
The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…
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Effect of Nanoparticles on Microbial Catabolism and Community Structure using Biolog techniques
1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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spFRET studies of nucleosome dynamics modulated by histone modifications, histone variants and neighboring nucleosomes
Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort
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Onderwijsonderzoek
Het ICLON doet wetenschappelijk onderzoek op het gebied van voortgezet en hoger onderwijs.
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Politieke Wetenschap
Het Instituut Politieke Wetenschap is een levendige, diverse gemeenschap met een wetenschappelijke staf van circa 70 onderzoekers. Het Instituut is gehuisvest in Leiden en Den Haag.
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Comparative biology of common and grey seals along the Dutch coast
What are the main factors associated with the stranding of the two seal species? What are the factors influencing the prevalence of disease in the two species? Which human-related factors influence the populations of the two seal species?
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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Leiden University MOOC experience
Since 2013, Leiden University has offered MOOCs in cooperation with Coursera. Over 80,000 students have enrolled in our MOOCs on European Law (Prof. dr Stefaan van den Bogaert) and on Terrorism & Counterterrorism (Prof. dr. Edwin Bakker).
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Media Technology MSc. Exhibition 50%
February 10th-12th & 16th-19th, Opening Thursday February 9th, 17:00.
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Summer Schools 2017: van biofarmacie tot papyrologie
Zin om eens een ander vakgebied te verkennen? Of juist een onderwerp uit je studie verder uit te diepen? Ook deze zomer biedt de Universiteit Leiden weer een brede selectie Summer Schools aan.
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Coptic Course NOSTER
NOSTER, the Dutch National research school for Theology and Religious Studies, organizes a Coptic Course in the fall of 2023. Students can enroll until October 1.
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Study trip Brussels advanced master Law and Digital Technologies
A small insight into the annual study trip to Brussels of the advanced master programme Law and Digital Technologies.
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Haentjens in oppositiecommissie Gent
Vorige week trad Matthias Haentjens op als opponent bij de promotie van Evariest Callens, welke plechtigheid in hybride vorm plaatsvond in de Ceremoniezaal van de Universiteit Gent.
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Nienke Bouw wint posterprijs op Nationaal Autisme Congres
Tijdens de 20ste editie van het Nationaal Autisme Congres van afgelopen maart won pedagoog Nienke Bouw de posterprijs voor haar onderzoek binnen de projectgroep TRIXY Expertisecentrum. Deze groep doet binnen een genetische ‘high risk’-groep, namelijk kinderen met een extra X of Y chromosoom, onderzoek…
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Giovanni De Gregorio en Pietro Dunn winnen Common Market Law Review-prijs voor jonge academici
De redactie van de Common Market Law Review is verheugd de winnaar van de Common Market Law Review-prijs voor een artikel van een jonge academicus voor het jaar 2021 aan te kondigen.
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Geef zorg op maat om het risico op toekomstig crimineel gedrag te verminderen
Jonge kinderen die moeilijk corrigeerbaar grensoverschrijdend of agressief gedrag vertonen, kunnen zich veelal lastig inleven in een ander. Vaak hebben zij moeite met het herkennen van emoties bij anderen en deze kinderen zijn minder goed in staat om hun gedrag te reguleren. Het promotieonderzoek van…
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Recordopbrengst Leiden Science Run voor wetenschappers in nood
De Leiden Science Run 2019 heeft een recordbedrag van 12.135 euro opgehaald voor Stichting voor vluchtelingstudenten UAF. Maar liefst 101 teams – eveneens een record – en de sponsoren CORPUS en Janssen Biologics brachten het bedrag bij elkaar.
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Elif Naz Kayran wint APSA prijs voor beste proefschrift
Dr. Elif Naz Kayran heeft de ‘Best Dissertation Award’ gekregen van de Migration & Citizenship Section van de American Political Science Association (APSA) voor haar proefschrift ‘Political Responses and Electoral Behaviour at Times of Socioeconomic Risk Inequalities and Immigration’.
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‘Wij academici en docenten van Security Studies kunnen direct invloed uitoefenen.'
In zijn oratie bepleit Joachim Koops dat de toekomst van Security and Global Affairs ligt in onderzoek, onderwijs en academisch bestuur.