144 zoekresultaten voor “active” in de Publieke website
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Bestrijdingsmiddelen en Milieu
The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Glucocerebrosidase and glycolipids: In and beyond the lysosome
The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.
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The heart of oxygenic photosynthesis illuminated
Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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“This Path Is Full of Thorns”: Narrative, Subjunctivity, and HIV in Indonesia
In this article, Samuels focuses on the active fostering of subjunctivity in processes of narrative worldmaking. Drawing extensively from the narrative of an HIV‐positive woman in Indonesia, she shows that by subjunctively leaving open multiple narrative trajectories and future possibilities, individuals…
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Chemical functionalization of the graphene surface for electrical and electrochemical sensing application
Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.
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Zipping into Fusion
Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros
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Vamping the Stage: Female Voices of Asian Modernities
Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).
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Dormancy in stochastic interacting systems
Organisms often need to adapt more efficiently and devise new strategies for surviving difficult ecological circumstances.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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New polymyxin antibiotics for old problems: addressing nephrotoxicity and resistance
Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…
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Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
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Noonan and LEOPARD syndrome in zebrafish: molecular mechanisms and cardiac development
Promotor: Prof.dr. J. den Hertog
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Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar
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Tuning in to the feedback bassline: revealing the operation of AGNs in galaxy clusters with high-resolution radio observations
Following the Big Bang, structure in the Universe started collapsing under the force of gravity. This resulted in the formation of the first stars, galaxies and clusters of galaxies.
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
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Political Muslims: Understanding Youth Resistance in a Global Context
An interdisciplinary collection of the best international scholarship on Muslim youth.
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Mechanistic studies of the water oxidation reaction with molecular iron catalysts
In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.
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Extremely loud & incredibly far: observing radio bright AGN into the cosmic dawn
In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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Activity-Based Proteasome Profiling
Promotor: Prof.dr. H.S. Overkleeft
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Distant star formation in the faint radio sky
One of the key quests in astronomy is to study the growth and evolution of galaxies across cosmic time. Radio observations provide a powerful means of studying the formation of stars and subsequent buildup of distant galaxies, in a way that is unbiased by the presence of dust.
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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The quantification of growth hormone secretion : application of model-informed drug development in acromegaly
Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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A chemical biology approach for targeting of ligand-drug conjugates
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot
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Novel analytical approaches to characterize particles in biopharmaceuticals
Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).
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PhD position: ultrafast broadband-THz spectroscopy of perovskite materials
Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)
- Symposia 2023-2024
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Hoe uitzaaiende tumoren hun omgeving naar hun hand zetten
Tumoren gedragen zich als mini-orgaantjes, manipuleren hun omgeving en gebruiken lichaamseigen processen om te overleven en uit te zaaien. Door onderzoek van Erik Danen en zijn collega’s komen we steeds meer te weten over de complexe aard van tumorcellen. In het NRC vertellen de wetenschappers over…
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Recommended weighting methods
The project falls in the context of the EU Thematic Strategy on the Sustainable Use of Natural Resources (COM(2005)670). The Institute for Environment and Resources (IES) of the Joint Research Centre (JRC) has developed three sets of decoupling indicators. Such indicators require the definition of a…
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Opleiding
Course Program 2023-2024
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LIFE-GREENAPI
Het ontwikkelen en demonstreren van innovatieve praktijken om met een lage milieu-impact farmaceutica te produceren.
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Informatica
Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…
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Exposure and health Assessment of Persistent Organic Pollutants (POPs) at e-waste recycling site among workers in the informal sector in Nigeria
Do e-waste workers display enhanced effects of adverse health effects due to informal e-waste processing in Nigeria? Is there a difference between the health outcomes of the exposed and the control groups? Are there difference in health effects within and between job groups (collectors, dismantlers,…
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Parttime programma
Sinds 2021 is de master ook in deeltijd te volgen, een parttime opleiding van 2-3 dagen per week, waarvan één vaste, verplichte dag op vrijdag.
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Nieuwe professor Luca Giomi creëert zijn eigen natuurkunde van levende systemen
Zwermen drones, voetgangers of de cellen in je lichaam. Dat zijn allemaal voorbeelden van actieve materie: materialen waarvan de bouwstenen autonoom kunnen bewegen. Dat is wat Luca Giomi bestudeert. Giomi is per 1 januari 2024 benoemd tot hoogleraar theoretische natuurkunde op het gebied van zachte…
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Hoe zwermen vogels zonder te botsen? Inzicht in collectieve bewegingen in heterogene populaties
De Leidse natuurkundigen Alexandre Morin en Samadarshi Maity bestuderen zelforganisatie en flocking-verschijnselen. Ze werpen licht op zwermgedrag, wat helpt om te begrijpen hoe het kan dat vogels in een zwerm niet botsen. Met plastic microkralen creëerden ze een experimentele opstelling en ze ontwikkelden…
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Interview met nieuwe universitair docent Alexandre Morin (video)
Het LION heeft er een nieuwe universitair docent bij: Alexandre Morin. Hij doet onderzoek naar Alexandre Morin is a new associate professor at LION, who will be researching actieve materie. In de onderstaande video (in het Engels) vertelt hij over zijn werk.
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Minuscule moleculaire bewegingen maken efficiëntere biobrandstofcel mogelijk
Leidse onderzoekers hebben minuscule bewegingen gevonden in het laccase-enzym. Deze ontdekking kan leiden tot de ontwikkeling van veel efficiëntere biobrandstofcellen. Publicatie in Biophysical Journal.
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Schonere brandstof door gepolijste kristallen?
De Leidse chemicus dr. Ludo Juurlink gaat in samenwerking met het Surface Preparation Laboratory onderzoeken of gekromde oppervlakken van éénkristallijn kobalt en vergelijkbare metalen net zo goed gepolijst kunnen worden als vlakke oppervlakken. Als dit inderdaad het geval is, kan dat een kleine revolutie…
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Het nieuwe studeren
In een eerder bericht zijn er al een aantal foto’s gepubliceerd over hoe Wijnhaven eruit zal komen te zien. Maar wat verandert er voor de studenten die vanaf begin 2017 hier hun nieuwe thuisbasis vinden?
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Temperature effects on genetic and physiological regulation of adaptive plasticity
Promotor: P.M. Brakefield
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LUMC-onderwijsprijs voor Sandra van Dijk & Co met 'The Older Individual’
Het nog jonge onderwijsblok 'The Older Individual' is door de studenten verkozen tot beste onderwijsblok van de masterspecialisatie Vitality & Ageing in Leiden. De LUMC-onderwijsprijs is voor gezondheidspsycholoog Sandra van Dijk en haar collega's.
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Wat komt er in het P.J. Veth-gebouw?
In het vernieuwde P.J. Vethgebouw komen onder meer collegezalen, ruimtes voor zelfstudie, werkplekken en -kamers en ruimtes voor ontmoeting, overleg en de innerlijke mens.
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Coptic Course NOSTER
NOSTER, the Dutch National research school for Theology and Religious Studies, organizes a Coptic Course in the fall of 2023. Students can enroll until October 1.
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COST Action subsidie voor Bart Custers
De European Cooperation in Science and Technology (COST) heeft een netwerksubsidie toegekend voor het project GoodBrother. Vanuit de Universiteit Leiden heeft Bart Custers, hoogleraar Law & Data Science en directeur van eLaw, Centrum voor Recht en Digitale Technologie, aan het voorstel meegeschreve…
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Collegezalen Arsenaal vanaf 3 maart in gebruik
Op 3 maart is het verbouwde Arsenaal er klaar voor. Studenten kunnen dan terecht in de twee collegezalen. Met de oplevering van het vernieuwde Arsenaal is opnieuw een stap gezet in de verwezenlijking van de Humanities Campus.